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公开(公告)号：US10570363B2
公开(公告)日：2020-02-25
申请号：US15294152
申请日：2016-10-14
申请人： Lonza Limited
发明人： Rex Polley , Matthew Sarcopski , Robert Horton , Thomas Ellis , Paul Pease , John Chapin
摘要： The disclosure is directed to a system and method for control of at least one bioreactor, other cell cultivation-related equipment, and systems containing any combination of these in a plant. For example, a Plant-Wide Control System (PWCS) or a Process Control System (PCS) may be divided into three main components: hardware (including operating systems, such as a controller communicating with one or more servers of a network associated with the PWCS, (2) software (such as a control module) for performing control, and (3) one or more instrument control loops, which may be used by the software to maintain certain process values. Moreover, a Height Equivalent of a Theoretical Plate (HETP) value and an asymmetry factor may be determined based on real-time analysis on a chromatography column, using PWCS components.
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公开(公告)号：US20190331701A1
公开(公告)日：2019-10-31
申请号：US16398860
申请日：2019-04-30
申请人： Lonza Limited
发明人： Rex POLLEY , Anna GUEST , Andrea PREUSS , Hans HUMMEL , Michael GOETTER
摘要： A system and method for monitoring an environment and performing analysis of collected samples are provided. The samples can be collected by personnel, a robot or a cobot, and the system may receive results of the monitoring/analysis and output information (e.g., alerts, reports, trends, forecasts) to environmental services, infection prevention personnel, and/or an electronic health/medical record system. If a contaminant is detected in the environment, appropriate personnel may automatically be alerted so that the contaminant can be eliminated/contained. The system may dynamically schedule the monitoring based on needs and ongoing changes in the environment, provide routing and work instructions to personnel, robots and/or cobots, and manage, maintain, and organize all information associated with the environmental monitoring so that information can be accessed, analyzed, and, if necessary, responded to, in real-time and/or in a timely manner, or where corrective actions need to be initiated as part of overall improvement plans.
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公开(公告)号：US20190264151A1
公开(公告)日：2019-08-29
申请号：US16406067
申请日：2019-05-08
申请人： Lonza Limited
发明人： Michael MIETZNER , Rajesh BERI , Edward GUNDERSON
摘要： A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.
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公开(公告)号：US20190055508A1
公开(公告)日：2019-02-21
申请号：US15771053
申请日：2016-10-26
申请人： Lonza Limited
发明人： Atul MOHINDRA
摘要： A manufacturing facility for the continuous production of biopharmaceuticals integrated with single-use disposable technology.
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公开(公告)号：US10370629B2
公开(公告)日：2019-08-06
申请号：US15629886
申请日：2017-06-22
申请人： Lonza Limited
发明人： Michael Mietzner , Rajesh Beri , Edward Gunderson
摘要： A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.
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公开(公告)号：US20180217172A1
公开(公告)日：2018-08-02
申请号：US15878930
申请日：2018-01-24
申请人： Lonza Limited
发明人： Dale WEBSTER , Evan CARPENTER
摘要： Systems and methods for dynamic automation are provided. An automation module, for example, may receive at least one map template that is selectable by a user. Based on the map template, the automation module may dynamically generate a robot deck layout map and/or procedure and also generate a series of robotic commands for a robot. The robotic commands may then be passed to the robot to carry out the automation. Accordingly, the automation may be entirely dynamic, without the need for a user to pre-program or pre-assemble all of the robotic commands prior to the automation. The automation module may thus be able to build, in real-time and/or on the fly, the robotic commands based only on the at least one map template that was selected by the user.
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17.发明申请公开(公告)号：US20180211447A1
公开(公告)日：2018-07-26
申请号：US15877987
申请日：2018-01-23
申请人： Lonza Limited
发明人： Randall SPAYD
摘要： A method of providing a virtual reality or augmented reality display is provided. The method includes generating, with a camera of a device, first video content (e.g., a first video stream) that may include a depiction of a component of a facility for the processing of a pharmaceutical product, e.g., a biological product and detecting or selecting the component (e.g., a vessel, a pipe between a holding tank and a filter). The method also includes generating second video content that may include an indicator associated with the component (e.g., a vessel, pipe, holding tank, or filter), where the first video content and the second video content provides a virtual reality or augmented reality display.
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公开(公告)号：US20170120244A1
公开(公告)日：2017-05-04
申请号：US14928666
申请日：2015-10-30
申请人： Lonza Limited
IPC分类号： B01L3/00
CPC分类号： B01L3/50855 , B01L3/50255 , B01L3/50853 , B01L2200/028 , B01L2300/041 , B01L2300/0681 , B01L2300/0829 , B01L2300/12
摘要： A filter plate with a flexible modular design. The filter plate has removable and completely closable rows and columns of wells, as well as removable and completely closable single or groups of wells.
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