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公开(公告)号：US20050143402A1
公开(公告)日：2005-06-30
申请号：US10979375
申请日：2004-11-01
Applicant: Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce Coll , Suzanne Renwick , Peter Weber
Inventor： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce Coll , Suzanne Renwick , Peter Weber
IPC: C12N9/12 , G06F19/00 , A61K31/517 , G01N33/48 , G01N33/50
CPC classification number: C12N9/1205 , C07K2299/00
Abstract: The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
Abstract translation: 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。
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12.发明申请INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3Beta PROTEIN AND PROTEIN COMPLEXES 失效GSK-3β蛋白和蛋白复合物GSK-3和晶体结构的抑制剂公开(公告)号：US20110129896A1
公开(公告)日：2011-06-02
申请号：US12944909
申请日：2010-11-12
Applicant: Ernst ter Haar , Lovorka Swenson
Inventor： Ernst ter Haar , Lovorka Swenson
IPC: C12N9/12
CPC classification number: C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
Abstract: The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
Abstract translation: 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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公开(公告)号：US20110104782A1
公开(公告)日：2011-05-05
申请号：US12890826
申请日：2010-09-27
Applicant: Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
Inventor： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
CPC classification number: C12N9/1205 , C07K2299/00
Abstract: The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
Abstract translation: 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。
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14.发明申请Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof 审中-公开丝裂原活化蛋白激酶激活蛋白激酶2的晶体结构及其结合口袋公开(公告)号：US20050261836A1
公开(公告)日：2005-11-24
申请号：US10497767
申请日：2002-12-05
Applicant: Wuyi Meng , Lovorka Swenson
Inventor： Wuyi Meng , Lovorka Swenson
CPC classification number: C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/573 , G16B15/00
Abstract: The invention relates to crystalline molecules or molecular complexes that comprise binding pockets of mitogen activated protein kinase activated protein kinase 2 (MAPKAPK2) or its homologues. The invention also relates to crystals comprising MAPKAPK2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of MAPKAPK2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, design and optimize compounds, including agonists and antagonists, which bind to MAPKAPK2 or homologues thereof.
Abstract translation: 本发明涉及包含丝裂原活化蛋白激酶活化蛋白激酶2（MAPKAPK2）或其同源物的结合口袋的结晶分子或分子复合物。 本发明还涉及包含MAPKAPK2的晶体。 本发明还涉及一种计算机，其包括用MAPKAPK2结合口袋的结构座标编码的数据存储介质和使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选，设计和优化与MAPKAPK2或其同源物结合的化合物，包括激动剂和拮抗剂的方法。
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公开(公告)号：US20050181975A1
公开(公告)日：2005-08-18
申请号：US10941387
申请日：2004-09-15
Applicant: James Griffith , James Black , Carlos Faerman , Lovorka Swenson , Michael Wynn , Fan Lu , Judith Lippke , Kumkum Saxena
Inventor： James Griffith , James Black , Carlos Faerman , Lovorka Swenson , Michael Wynn , Fan Lu , Judith Lippke , Kumkum Saxena
CPC classification number: C12N9/1205 , C07K2299/00 , C12Y207/10001
Abstract: The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.
Abstract translation: 本发明涉及FMS样酪氨酸激酶（FLT3），FLT3结合袋或FLT3样结合口袋。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合FMS样酪氨酸激酶蛋白的化合物，FMS样酪氨酸激酶蛋白的复合物，其同源物或FLT-3样蛋白或蛋白复合物的方法。 本发明还涉及可结晶组合物和包含FMS样酪氨酸激酶细胞质结构域或其同系物的晶体。 本发明还涉及鉴定FMS样酪氨酸激酶蛋白的细胞质结构域的抑制剂的方法。
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Patent Agency Ranking
16.发明授权Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes 失效GSK-3的抑制剂和GSK-3＆bgr的晶体结构; 蛋白质和蛋白质复合物公开(公告)号：US08318467B2
公开(公告)日：2012-11-27
申请号：US12944909
申请日：2010-11-12
Applicant: Ernst ter Haar , Lovorka Swenson
Inventor： Ernst ter Haar , Lovorka Swenson
CPC classification number: C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
Abstract: The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
Abstract translation: 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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17.发明授权Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes 有权GSK-3的抑制剂和GSK-3＆bgr的晶体结构; 蛋白质和蛋白质复合物公开(公告)号：US07883881B2
公开(公告)日：2011-02-08
申请号：US12652152
申请日：2010-01-05
Applicant: Ernst ter Haar , Lovorka Swenson , Jeremy Green , Michael J. Arnost
Inventor： Ernst ter Haar , Lovorka Swenson , Jeremy Green , Michael J. Arnost
CPC classification number: C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
Abstract: The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
Abstract translation: 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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18.发明申请CRYSTAL STRUCTURE OF HUMAN JAK3 KINASE DOMAIN COMPLEX AND BINDING POCKETS THEREOF 失效人类JAK3激酶复合体的结晶结构及其结合位点公开(公告)号：US20110014680A1
公开(公告)日：2011-01-20
申请号：US12471896
申请日：2009-05-26
Applicant: HARMON ZUCCOLA , MARC JACOBS , LOVORKA SWENSON , KUMKUM SAXENA
Inventor： HARMON ZUCCOLA , MARC JACOBS , LOVORKA SWENSON , KUMKUM SAXENA
IPC: C12N9/12
CPC classification number: C12Q1/485 , C07K2299/00 , C12N9/1205 , G01N33/573 , G01N33/57496 , G01N33/6872 , G01N2500/00
Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
Abstract translation: 本发明涉及人类Janus Kinase 3（JAK3）和JAK3样结合口袋。 本发明提供了一种计算机，其包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合JAK3蛋白或JAK3蛋白同源物的化合物（包括抑制性化合物）或其复合物的方法。 本发明还涉及可结晶组合物和包含与AMP-PNP复合的JAK3激酶结构域和JAK3激酶结构域的晶体。
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19.发明申请INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES 有权GSK-3和GSK-3BETA蛋白和蛋白复合物的晶体结构的抑制剂公开(公告)号：US20100227814A1
公开(公告)日：2010-09-09
申请号：US12652152
申请日：2010-01-05
Applicant: Ernst ter Haar , Lovorka Swenson , Jeremy Green , Michael J. Arnost
Inventor： Ernst ter Haar , Lovorka Swenson , Jeremy Green , Michael J. Arnost
CPC classification number: C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
Abstract: The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
Abstract translation: 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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20.发明授权Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes 失效GSK-3的抑制剂和GSK-3＆bgr的晶体结构; 蛋白质和蛋白质复合物公开(公告)号：US07666647B2
公开(公告)日：2010-02-23
申请号：US12079917
申请日：2008-03-28
Applicant: Ernst ter Haar , Lovorka Swenson , Jeremy Green , Michael J. Arnost
Inventor： Ernst ter Haar , Lovorka Swenson , Jeremy Green , Michael J. Arnost
CPC classification number: C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
Abstract: The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
Abstract translation: 本发明涉及GSK-3抑制剂及其制备方法。 本发明还提供包含抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病如糖尿病和阿尔茨海默氏病的方法。 此外，本发明涉及包含GSK-3和bgr的结合口袋的分子或分子复合物。 或其同系物。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标筛选和设计结合GSK-3和bgr的化合物的方法; 蛋白质或其同系物。 本发明还涉及可结晶组合物和包含GSK-3和bgr的晶体; 蛋白质或GSK-3＆bgr; 蛋白复合物。
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