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公开(公告)号：US06683045B2
公开(公告)日：2004-01-27
申请号：US09941571
申请日：2001-08-30
IPC分类号： A01N6100
摘要： Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.
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12.发明授权
公开(公告)号：US5048457A
公开(公告)日：1991-09-17
申请号：US531711
申请日：1990-05-31
申请人： Julius Hyman, Jr. , John R. Beattie , Jesse N. Matossian , Owen K. Wu , Juan F. Lam , Lawrence Anderson
发明人： Julius Hyman, Jr. , John R. Beattie , Jesse N. Matossian , Owen K. Wu , Juan F. Lam , Lawrence Anderson
IPC分类号： C30B23/02
摘要： A molecular beam epitaxy (MBE) growth method and apparatus is disclosed which achieves a significantly improved sticking coefficient for materials like Hg upon a substrate, and thus a higher efficiency. A highly ionized, low pressure plasma is formed consisting of a mixture of ions of one substance of a compound to be epitaxially grown, neutral particles of the substance and electrons, and also preferably both ionization and excitation radiation. The plasma is directed onto a substrate together with a flux of the other substance in the compound; the flux can be in the form of either a vapor, or a second plasma. Radiation assisted epitaxial growth for Hg compounds in which ionization and excitation radiation are formed from Hg vapor and used to assist epitaxial growth with neutral Hg particles is also described. The plasma is formed in a special discharge chamber having a hollow cathode with an emissive-mix-free cathode insert. The source is preferably a refractory metal such as rolled tantalum foil, which is substantially emissive-material-free and does not contaminate the plasma. Good results are obtained by allowing the plasma to simply diffuse out through an exit port in the discharge chamber, without special extraction assemblies required by prior ion thrusters. Hg sticking coefficients have been improved by a factor of 40 or more.
摘要翻译： 公开了一种分子束外延（MBE）生长方法和装置，其实现了对衬底上的诸如Hg的材料的显着改善的粘附系数，并且因此具有更高的效率。 形成高离子化的低压等离子体，其由外延生长的化合物的一种物质的离子和物质的中性粒子和电子的混合物组成，并且还优选电离和激发辐射。 等离子体与化合物中另一种物质的助熔剂一起引导到基底上; 通量可以是蒸汽或第二等离子体的形式。 还描述了汞化合物的辐射辅助外延生长，其中电离和激发辐射由Hg蒸气形成并用于辅助外延生长与中性Hg颗粒。 等离子体形成在具有空心阴极的特殊放电室中，其具有无发射混合阴极插入物。 来源优选是难熔金属，例如轧制钽箔，其基本上不发射材料，并且不污染等离子体。 通过允许等离子体简单地通过放电室中的出口扩散出来，而不需要先前的离子推进器所需的特殊提取组件，可获得良好的结果。 Hg粘附系数提高了40倍以上。
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公开(公告)号：US20120029444A1
公开(公告)日：2012-02-02
申请号：US13132289
申请日：2009-12-04
CPC分类号： A61M25/0012 , A61B18/1492 , A61B90/39 , A61B2017/00526 , A61B2018/00011 , A61B2018/00029 , A61B2217/007 , A61B2218/002 , A61M25/005
摘要： A catheter sheath for an irrigation catheter comprises an elongate member having a proximal end and a distal end and defining a lumen extending from the proximal end to the distal end. At least one electrode is arranged on the elongate member. A plurality of elongate elements are contained in the elongate member, the elongate elements comprising at least one electrical conductor and at least one element of a non-conductive material arranged adjacent the at least one conductor to form at least one non-conductive region associated with the elongate member. At least one passage extends through a wall of the elongate member to intersect the non-conductive region and to be in communication with the lumen of the elongate member. The at least one passage has an outlet opening in, or adjacent, the at least one electrode.
摘要翻译： 用于冲洗导管的导管护套包括具有近端和远端并且限定从近端延伸到远端的内腔的细长构件。 至少一个电极布置在细长构件上。 多个细长元件包含在细长构件中，细长元件包括至少一个电导体和非导电材料的至少一个元件，其布置成与该至少一个导体相邻以形成至少一个非导电区域 细长构件。 至少一个通道延伸穿过细长构件的壁以与非导电区域相交并且与细长构件的内腔连通。 所述至少一个通道在至少一个电极中或邻近所述至少一个电极具有出口开口。
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公开(公告)号：US07629015B2
公开(公告)日：2009-12-08
申请号：US11123392
申请日：2005-05-05
CPC分类号： A61B5/0408 , A61B5/042 , A61B5/0478 , A61B2562/125 , A61N1/05 , Y10T29/49117 , Y10T29/49224 , Y10T428/13 , Y10T428/1303 , Y10T428/1334 , Y10T428/1338 , Y10T428/1352 , Y10T428/139
摘要： An electrically conductive member (10) includes an elongate body (11) which has at least one electrically conductive region (20). The electrically conductive region (20) comprises a porous polymeric material coated with an electrically conductive material. A method of manufacturing the electrically conductive member (10) includes the steps of extruding an elongate body of polymeric material wherein at least one region of the elongate body is porous in nature; and coating said elongate body with an electrically conductive material such that the electrically conductive material substantially coats the pores of said at least one region.
摘要翻译： 导电构件（10）包括具有至少一个导电区域（20）的细长主体（11）。 导电区域（20）包括涂覆有导电材料的多孔聚合物材料。 制造导电构件（10）的方法包括挤压聚合材料的细长体的步骤，其中细长体的至少一个区域本质上是多孔的; 以及用导电材料涂覆所述细长体，使得导电材料基本上涂覆所述至少一个区域的孔。
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公开(公告)号：US20080275389A1
公开(公告)日：2008-11-06
申请号：US11885025
申请日：2006-03-01
IPC分类号： A61M25/092 , A61F7/12
CPC分类号： A61M25/0136 , A61B18/1492 , A61B2017/003
摘要： A catheter handle (10) includes a handle body (12) having a proximal end (14) and a distal end (16) with a receiving formation (18) being defined at the distal end (16) for receiving a catheter arrangement. A steering control mechanism (22) is carried by the handle body (12), a steering device of the catheter arrangement being connectable to the steering control mechanism (22). At least one introducer zone (24) is defined by a part of the handle body (12) and is in communication with the distal end (16) of the handle body (12). A shape forming element is able to be introduced, in use, via the introducer zone (24) into a lumen of a catheter of the catheter arrangement received by the receiving formation (18).
摘要翻译： 导管手柄（10）包括具有近端（14）和远端（16）的手柄本体（12），其中在远端（16）处限定用于接收导管装置的接收构件（18）。 转向控制机构（22）由把手主体（12）承载，导管装置的转向装置可连接到转向控制机构（22）。 至少一个导引器区域（24）由手柄主体（12）的一部分限定，并且与手柄主体（12）的远端（16）连通。 成形元件能够在使用中通过导引器区域（24）引入由接收构件（18）接收的导管装置的导管的内腔中。
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公开(公告)号：US20080275388A1
公开(公告)日：2008-11-06
申请号：US11885024
申请日：2006-03-01
IPC分类号： A61M25/092
CPC分类号： A61M25/0136 , A61B18/1492 , A61B2017/003 , A61M2025/0063
摘要： A catheter handle 10 includes a handle body (12). A steering control mechanism (14) is displaceably carried on the handle body (12). An electrode sheath carrier (16) is carried on the handle body (12), the electrode sheath carrier (16) being displaceable at least relative to the steering control mechanism (14).
摘要翻译： 导管手柄10包括手柄主体（12）。 转向控制机构（14）可移动地承载在把手主体（12）上。 电极护套载体（16）承载在手柄主体（12）上，电极护套载体（16）至少可以相对于转向控制机构（14）移动。
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公开(公告)号：US07141234B1
公开(公告)日：2006-11-28
申请号：US10088561
申请日：2000-09-21
IPC分类号： A61K49/00
CPC分类号： A61K51/0491 , A61K51/0417 , A61K51/0421 , A61K51/0455
摘要： The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging. The method is used to monitor delivery of antitumor drugs to tumors and may be used to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g., 11C-paclitaxel and 11C-docetaxel, labeled anthracyclines, e.g., 11C-doxorubicin and 11C-epirubicin, and other radio-labeled drug, e.g. 11C-topotecan and 11C-mitoxantrone. The invention further describes antitumor drugs labeled with the radioactive label 11C and methods of preparing radio-labeled drugs.
摘要翻译： 本发明描述了通过向患者施用放射性标记的抗癌药物并使用正电子发射断层扫描成像对至少一部分患者进行成像的方法来使用放射性标记的抗肿瘤药物来治疗实体瘤。 该方法用于监测抗肿瘤药物对肿瘤的递送，并且可用于预测用特定抗肿瘤药物或抗肿瘤药物组合治疗的有效性，以评估细胞积聚调节剂的有效性，个体化治疗和评价 抗肿瘤药物对特定癌症的有效性。 特别优选的药物是标记的紫杉烷类，例如，11 C-紫杉醇和11 C-多西他赛，标记的蒽环类药物，例如，11-多柔比星和 C-表柔比星和其他放射性标记的药物，例如， C-托泊替康和11-西米托蒽醌。 本发明还描述了用放射性标记物11C标记的抗肿瘤药物和制备放射性标记药物的方法。
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公开(公告)号：US06682715B2
公开(公告)日：2004-01-27
申请号：US09941721
申请日：2001-08-30
IPC分类号： A61K5100
摘要： Methods of diagnosing and/or of treating tumors by administering a nucleoside analog which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analog compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.
摘要翻译： 通过将由胸苷酸合酶和/或胸苷激酶所激活的核苷类似物施用于诊断或毒性代谢物，以及尿苷类似物化合物及其具有药学上可接受的载体的组合物来诊断和/或治疗肿瘤的方法。 对于诊断应用，描述了含有标记的化合物和使用这些化合物的方法。
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公开(公告)号：US06677314B2
公开(公告)日：2004-01-13
申请号：US09941550
申请日：2001-08-30
IPC分类号： A01N4304
摘要： Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described
摘要翻译： 通过将由胸苷酸合酶和/或胸苷激酶酶活化的核苷类似物施用于诊断或毒性代谢物，以及尿苷类似物化合物及其具有药学上可接受的载体的组合物来诊断和/或治疗肿瘤的方法。 对于诊断应用，描述了含有标记的化合物和使用这些化合物的方法
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公开(公告)号：US4240161A
公开(公告)日：1980-12-23
申请号：US13375
申请日：1979-02-21
CPC分类号： A61F2/2406 , Y10T137/7903
摘要： A free floating pivoting disc heart valve in which the disc has a generally arcuate segment configuration positioned so as to present a generally convex surface toward the outflow side of said base and a generally concave surface toward the inflow side of the base when viewed in the closed configuration.
摘要翻译： 一种自由浮动的枢转心脏瓣膜，其中盘具有大致弓形的段构造，其定位成当在闭合状态下观察时呈现朝向所述基部的流出侧的大致凸形表面和朝向底部的流入侧的大致凹入表面 组态。
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