公开(公告)号：US20190049429A1

公开(公告)日：2019-02-14

申请号：US16085755

申请日：2017-07-18

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kie Nakashima ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Kiyotoshi Sekiguchi ,  Atsushi Tanemura ,  Hiroyuki Murota ,  Ichiro Katayama

IPC: G01N33/50 ,  A61B5/00

Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.

公开(公告)号：US20230057230A1

公开(公告)日：2023-02-23

申请号：US17789867

申请日：2021-01-07

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY ,  PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY

Inventor： Manami Toriyama ,  Fumitaka Fujita ,  Fumihiro Okada ,  Akimichi Morita ,  Motoki Nakamura

IPC: G01N33/574

Abstract: The present invention provides a novel method for detecting an indicator of T cell lymphoma. The method for detecting an indicator of T cell lymphoma includes the step of detecting acetylated tubulin in a T cell that has been collected from a subject.

公开(公告)号：US11060061B2

公开(公告)日：2021-07-13

申请号：US16626052

申请日：2018-08-07

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Tomohisa Hayakawa ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Fumihiro Okada ,  Kiyotoshi Sekiguchi

IPC: C12N5/077 ,  C12N15/85 ,  C12N15/86

Abstract: An immortalized sweat gland myoepithelial cell which expresses α-SMA and pan-cytokeratin and has a sphere forming ability after subculture at least 5 times. A method for producing immortalized sweat gland myoepithelial said method comprising: while culturing a cell structure, wherein sweat gland myoepithelial cells are exposed on a surface, in a state of being suspended in a medium, transferring an immortalizing gene into the cells; and then culturing the transgenic structure thus obtained in a state of being suspended in the medium to thereby obtain immortalized sweat gland myoepithelial cells.

公开(公告)号：US11047849B2

公开(公告)日：2021-06-29

申请号：US16769719

申请日：2019-09-05

Applicant: MANDOM CORPORATION

Inventor： Shuta Ishizuka ,  Ryuichiro Kurata

IPC: G01N33/50 ,  G01N33/15 ,  G01N1/28

Abstract: Provided is a method for observing a sebaceous gland, the method making it possible to observe dynamics of a sebaceous gland which dynamics are close to dynamics of a sebaceous gland in a living body. The method includes: an anchoring step of anchoring a sebaceous gland structure to a support so that a sebaceous gland that is included in the sebaceous gland structure and is to be observed and the support are not in biological contact with each other, the sebaceous gland structure being obtained by removing all or part of each of dermis and hypodermis from a skin tissue; and an observation step of observing the sebaceous gland structure obtained in the anchoring step.

公开(公告)号：US20150202127A1

公开(公告)日：2015-07-23

申请号：US14415493

申请日：2013-12-04

Applicant: MANDOM CORPORATION

Inventor： Takeshi Hara ,  Hironori Shimizu

IPC: A61K8/19 ,  A61K8/29 ,  A61Q15/00 ,  A61K8/02

CPC classification number: A61K8/29 ,  A61K8/0241 ,  A61K8/0279 ,  A61K8/046 ,  A61K8/19 ,  A61K2800/412 ,  A61K2800/621 ,  A61K2800/651 ,  A61Q15/00

Abstract: The present invention provides a body odor suppressing agent that contains activated carbon and that has excellent body odor suppressing effects, causes no black soiling on an object to be coated, and has excellent practical aptitude. The present invention also provides a body odor suppressing agent having an excellent feeling of use when the agent is applied to the skin. The present invention further provides a body odor suppressing agent capable of preventing nozzles from clogging when the agent is packed into a spray container and used. The body odor suppressing agent of the present invention includes a titanium oxide-coated activated carbon including an activated carbon having an average particle diameter of 15 to 50 μm and a titanium oxide present over the surface of the activated carbon.

Abstract translation: 本发明提供一种含有活性炭的身体臭味抑制剂，具有优异的除臭效果，对被涂物没有黑色污渍，具有优异的实用性。 本发明还提供了当将药剂施用于皮肤时具有优异的使用感的身体臭味抑制剂。 本发明还提供一种防臭剂，其能够防止在将试剂装入喷雾容器并使用时堵塞喷嘴。 本发明的体臭抑制剂包括包含平均粒径为15〜50μm的活性炭和存在于活性炭表面的氧化钛的氧化钛被覆活性炭。

公开(公告)号：US20150013712A1

公开(公告)日：2015-01-15

申请号：US14388776

申请日：2013-03-27

Applicant: MANDOM CORPORATION

Inventor： Takeharu Ishii ,  Takuji Asada

IPC: A61K8/92 ,  A61Q5/06 ,  A61K8/25 ,  B29C43/00 ,  A61K8/31 ,  A61K8/49 ,  A61K8/37 ,  A45D7/04 ,  A61K8/26

CPC classification number: A61K8/927 ,  A45D7/04 ,  A45D2007/002 ,  A61K8/022 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/31 ,  A61K8/37 ,  A61K8/492 ,  A61K8/64 ,  A61K8/731 ,  A61K8/8111 ,  A61K8/8117 ,  A61K8/8123 ,  A61K8/8152 ,  A61K8/84 ,  A61K8/88 ,  A61K8/891 ,  A61K8/92 ,  A61K8/922 ,  A61Q5/00 ,  A61Q5/06 ,  B29C43/003

Abstract: The present invention provides a powdery solid hair cosmetic that enables easy hairdressing, enables hairdressing into an intended hairstyle without sticky feeling, can impart a natural texture, and has an unprecedented, novel form. The powdery solid composition for hair of the present invention is in a powdery solid form, is used for hair, and contains a powder and an oil.

Abstract translation: 本发明提供了一种粉状固体发质化妆品，其能够容易地美发，使得美发成为无粘性感的预期发型，可赋予自然的质感，并且具有前所未有的新颖形式。 本发明的毛发用粉状固体组合物为粉末状固体形式，用于毛发，含有粉末和油状物。