公开(公告)号：US20210226476A1

公开(公告)日：2021-07-22

申请号：US17055588

申请日：2019-05-13

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Ziv ROTFOGEL ,  Nadav COHEN

IPC: H02J50/00 ,  G02C7/04 ,  G02C11/00 ,  H02J7/00 ,  H02J50/10 ,  A61F2/16

Abstract: A system for providing electrical energy to an implanted device or to a device attached to a body. The system includes one or more permanent magnets attached to or implanted in a first body part and one or more inductor(s) attached to or implanted in a second body part. The inductor(s) are electrically couplable to the implanted device for providing the implanted device with electrical currents flowing in the one or more inductor(s) in response to changes in the position and/or orientation of the permanent magnet(s) relative to the position and/or orientation of the inductor(s). The system may include a current rectifier for rectifying electrical currents provided by the inductor(s). The system may also include a charge storage device electrically coupled to the current rectifier for storing electrical energy received from the current rectifier.

公开(公告)号：US20210196717A1

公开(公告)日：2021-07-01

申请号：US17057845

申请日：2019-05-23

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  BAR ILAN UNIVERSITY

Inventor： Edith HOCHHAUSER ,  Arie-Lev GRUZMAN ,  Elena TRIFONOV

IPC: A61K31/513 ,  C07D239/47 ,  A61P9/10 ,  C07K5/103 ,  C07K5/113 ,  C07K5/107 ,  C07K5/087 ,  C07K5/083 ,  A61K38/07 ,  A61K38/06

Abstract: Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.

公开(公告)号：US20210116444A1

公开(公告)日：2021-04-22

申请号：US16493874

申请日：2018-03-15

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： Liron YOFFE ,  Noam SHOMRON ,  Moshe HOD

IPC: G01N33/53

Abstract: Methods and kits for identifying an increased risk of developing preeclampsia in a pregnant woman based on expression pattern of non-coding RNAs in body fluids are provided. In particular, the methods provide information for identifying a pregnant woman as being at risk of developing preeclampsia by analyzing the pattern of non-coding RNAs in body fluids during early stages of pregnancy.

公开(公告)号：US20200030282A1

公开(公告)日：2020-01-30

申请号：US16491243

申请日：2018-03-05

Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization ,  Mor Research Applications Ltd.

Inventor： Hinanit KOLTAI ,  Yoram KAPULNIK ,  Dvora NAMDAR ,  Moran MAZUZ ,  Ido LAISH ,  Timna NAFTALI

IPC: A61K31/353 ,  A61K31/05 ,  A61K31/015 ,  A61K31/01 ,  A61K31/194 ,  A61K31/045 ,  A61K31/12

Abstract: A method of treating a malignant disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a first liquid chromatography fraction of a Cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), and a therapeutically effective amount of a second liquid chromatography fraction of a Cannabis extract comprising at least 75% cannabigerolic acid (CBGA), wherein the first liquid chromatography fraction comprises Cannabis derived active ingredients other than the THCA, and the second liquid chromatography fraction comprises Cannabis derived active ingredients other than the CBGA, thereby treating the malignant disease in the subject.

公开(公告)号：US20190298271A1

公开(公告)日：2019-10-03

申请号：US16316395

申请日：2017-07-10

Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： Yaniv ZIGEL ,  Dvir BEN OR ,  Ariel TARASIUK ,  Eliran DAFNA

IPC: A61B5/00 ,  A61B7/00 ,  G16H50/30

Abstract: Provided herein is a method and system for the estimation of apnea-hypopnea index (AHI), as an indicator for Obstructive sleep apnea (OSA) severity, by combining speech descriptors from three separate and distinct speech signal domains. These domains include the acoustic short-term features (STF) of continuous speech, the long-term features (LTF) of continuous speech, and features of sustained vowels (SVF). Combining these speech descriptors may provide the ability to estimate the severity of OSA using statistical learning and speech analysis approaches.

公开(公告)号：US20190216460A1

公开(公告)日：2019-07-18

申请号：US16303188

申请日：2017-05-23

Applicant: Mor Research Applications Ltd.

Inventor： Doron KOPELMAN

IPC: A61B17/11 ,  A61B17/12 ,  A61B17/32

CPC classification number: A61B17/1114 ,  A61B17/083 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12136 ,  A61B17/1227 ,  A61B17/32 ,  A61B17/32053 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/00557 ,  A61B2017/00818 ,  A61B2017/00867 ,  A61B2017/00876 ,  A61B2017/081 ,  A61B2017/1139 ,  A61B2017/12004 ,  A61B2090/065

Abstract: According to some embodiments there is provided an anastomosis device configured to reduce leakage, comprising: a first set of rings sized to be positioned at a first tissue wall; a second set of rings sized to be positioned at a second tissue wall adjacent the first tissue wall; and an element configured to draw the ring sets towards each other; wherein each set of rings comprises an inner ring, an outer ring, and a coupling for aligning the inner and outer rings with respect to each other; wherein the inner ring applies a first pressure onto the tissue wall which is sufficient to gradually form a passage between the first and second tissue walls; and the outer ring applies a second pressure onto the tissue wall, the second pressure applied radially outwardly relative to the first pressure, the second pressure sufficient to reduce leakage in a vicinity of the passage.

公开(公告)号：US20190100731A1

公开(公告)日：2019-04-04

申请号：US16085623

申请日：2017-03-17

Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat ,  Mor Research Applications Ltd.

Inventor： Hinanit KOLTAI ,  Yoram KAPULNIK ,  Marcelo FRIDLENDER ,  Timna NAFTALI

IPC: C12N5/071 ,  G01N33/50

Abstract: A method of preparing an ex-vivo intestinal culture model is provided. The method comprising: (a) providing an intestinal tissue sample; (b) treating the intestinal tissue sample with a protease cleaving an extracellular matrix (ECM) component so as to break cell-cell contacts and obtain an intestinal preparation which maintains the overall intestinal tissue structure including villi and/or intestinal tissue layer orientation; (c) washing the preparation; and (d) culturing the preparation.

公开(公告)号：US20180360810A1

公开(公告)日：2018-12-20

申请号：US16060377

申请日：2016-12-08

Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： Avi GOLAN-GOLDHIRSH ,  Jacob GOPAS ,  Udi ZURGIL

IPC: A61K31/438 ,  A61K31/4375 ,  A61K36/62

Abstract: Disclosed a method of treating a disease or a disorder characterized by protease activity. A pharmaceutical composition for treating a disease or a disorder characterized by protease activity is further disclosed. A method of detecting a cysteine protease from a biological sample is also disclosed.

公开(公告)号：US10130682B2

公开(公告)日：2018-11-20

申请号：US15129007

申请日：2015-03-30

Applicant: Ramot at Tel-Aviv University Ltd. ,  Mor Research Applications Ltd.

Inventor： Ruth Shalgi ,  Dana Chuderland ,  Hadas Bar-Joseph ,  Keren Goldberg ,  Irit Ben-Aharon ,  Salomon M. Stemmer

IPC: A61K38/18 ,  A61K31/138 ,  A61K31/704 ,  C12N5/075 ,  G01N33/74

Abstract: A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.

公开(公告)号：US20180271704A1

公开(公告)日：2018-09-27

申请号：US15571289

申请日：2016-05-03

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Tova LIFSHITZ ,  Nadav Yaakov BELFAIR ,  Eliyahu BSHARIM ,  Eliahu ELIACHAR ,  Nir LILACH ,  Nathan BUKHDRUKER

IPC: A61F9/007

CPC classification number: A61F9/00754 ,  A61F9/007 ,  A61F9/00763

Abstract: Aspects of embodiments relate to a surgical device for assisting a user of the device to cut a circular incision in an anterior lens capsule tissue, the device comprising an arm member having a proximal end and a distal end, wherein the distal end of the arm member is operative to receive a cutting member; and an actuator arrangement comprising an actuating handle operatively coupled with the arm member, such that, responsive to an operating input provided at the actuating handle, the distal end of the arm member traverses a circular path around a first axis of the tissue to cause the cutting member to form a circular incision in the tissue along the circular path.