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公开(公告)号：US20190000973A1
公开(公告)日：2019-01-03
申请号：US15780654
申请日：2016-12-05
申请人： Manzoor KOYAKUTTY , Anusha ASHOKAN , Vijay HARISH , Shantikumar NAIR , Amrita Vishwa Vidyapeetham , DEPARTMENT OF BIOTECHNOLOGY
摘要： The invention discloses nanoparticles comprising compounds of calcium with anions such as phosphate, pyrophosphate, sulphate, silicate, carbonate, molybdate, or phosphosilicate that are doped with various ions. The nanoparticles are configured to produce heat (hyperthermia) under radio-wave (1 KHz-1000 GHz) exposure together with magnetism suitable for contrast imaging in MRI, X-ray absorption for computed tomography, near-infrared optical fluorescence for optical imaging, and/or radio-isotope emission for nuclear imaging or therapy. The nanoparticles can also be incorporated into micro-beads or other 3 dimensional scaffolds for image-guided (MRI, CT, NIR, nuclear) tissue regeneration, immunotherapy, vascular or tumor embolization, and/or chemo/radio-embolization.
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公开(公告)号：US20170196811A1
公开(公告)日：2017-07-13
申请号：US15198153
申请日：2016-06-30
IPC分类号： A61K9/16 , A61K31/704 , A61K31/506 , A61K31/337 , A61K31/436 , A61K31/44
CPC分类号： A61K9/167 , A61K9/1635 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/5138 , A61K9/5153 , A61K9/5161 , A61K9/5169 , A61K9/5192 , A61K31/337 , A61K31/436 , A61K31/437 , A61K31/44 , A61K31/506 , A61K31/704 , A61K45/06 , A61K47/6803 , A61K47/6927 , A61K47/6931 , A61K47/6933 , A61K47/6935 , A61K47/6939
摘要： A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, core-shell particle formulation configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enables treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
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13.发明申请公开(公告)号：US20150209288A1
公开(公告)日：2015-07-30
申请号：US14585013
申请日：2014-12-29
IPC分类号： A61K9/16 , A61K45/06 , A61K31/44 , A61K31/713 , A61K31/436 , A61K31/506
CPC分类号： A61K9/5169 , A61K9/0019 , A61K9/167 , A61K31/436 , A61K31/44 , A61K31/506 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/40 , A61K39/44 , A61K45/06 , A61K47/643 , A61K47/644 , A61K47/645 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6929 , A61K2300/00
摘要： A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, the formulation comprising protein-protein core-shell particle configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enable treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
摘要翻译： 公开了用于递送多种治疗剂的核 - 壳颗粒制剂。 更具体地，包含被配置成独立地从核心和壳体释放治疗药物的蛋白质 - 蛋白质核 - 壳颗粒的制剂。 此外，具有核壳颗粒的治疗剂能够治疗诸如癌症，炎症和自身免疫疾病的疾病。
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公开(公告)号：US08287951B2
公开(公告)日：2012-10-16
申请号：US12088590
申请日：2006-06-27
申请人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
发明人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
IPC分类号： B05D7/00
CPC分类号： H01L33/285 , C09K11/642 , C30B7/00 , C30B29/16 , C30B29/48 , C30B29/605 , Y10T428/2991
摘要： A process for preparing a single source solid precursor matrix for semiconductor nanocrystals having the steps of: mixing 0.1-1 Molar of an aqueous/non-aqueous (organic) solution containing the first component of the host matrix with 0.001-0.01 Molar of an aqueous/non-aqueous solution containing the first dopant ions, which needs in situ modification of valency state, dissolving 10-20 milligram of an inorganic salt for the in situ reduction of the first dopant ion in the solution, addition of 0.001-0.01 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the dopant ions which do not need modifications of their valency state, addition of 0.1-1 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the second component of the host material, addition of 5-10% by weight of an aqueous solution containing a pH modifying complexing agent, to obtain a mixture, and heating the mixture to obtain a solid layered micro-structural precursor compound.
摘要翻译： 制备用于半导体纳米晶体的单源固体前体基质的方法，其具有以下步骤：将含有主体基质的第一组分的0.1-1摩尔水/非水（有机）溶液与0.001-0.01摩尔的水性 /含有第一掺杂剂离子的非水溶液，其需要原位改性的价态，将10-20毫克的无机盐溶解在溶液中原位还原第一掺杂剂离子，加入0.001-0.01摩尔 含有不需要改变其价态的掺杂剂离子的无机盐的水/非水溶液，加入0.1-1摩尔含有主体第二组分的无机盐的水/非水溶液 添加5-10重量％的含有pH改性络合剂的水溶液，得到混合物，加热混合物，得到固体层状微结构前体化合物。
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公开(公告)号：US20090218550A1
公开(公告)日：2009-09-03
申请号：US12088590
申请日：2006-06-27
申请人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
发明人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
CPC分类号： H01L33/285 , C09K11/642 , C30B7/00 , C30B29/16 , C30B29/48 , C30B29/605 , Y10T428/2991
摘要： A process for preparing a single source solid precursor matrix for semiconductor nanocrystals having the steps of: mixing 0.1-1 Molar of an aqueous/non-aqueous (organic) solution containing the first component of the host matrix with 0.001-0.01 Molar of an aqueous/non-aqueous solution containing the first dopant ions, which needs in situ modification of valency state, dissolving 10-20 milligram of an inorganic salt for the in situ reduction of the first dopant ion in the solution, addition of 0.001-0.01 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the dopant ions which do not need modifications of their valency state, addition of 0.1-1 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the second component of the host material, addition of 5-10% by weight of an aqueous solution containing a pH modifying complexing agent, to obtain a mixture, and heating the mixture to obtain a solid layered micro-structural precursor compound.
摘要翻译： 制备用于半导体纳米晶体的单源固体前体基质的方法，其具有以下步骤：将含有主体基质的第一组分的0.1-1摩尔水/非水（有机）溶液与0.001-0.01摩尔的水性 /含有第一掺杂剂离子的非水溶液，其需要原位改性的价态，将10-20毫克的无机盐溶解在溶液中原位还原第一掺杂剂离子，加入0.001-0.01摩尔 含有不需要改变其价态的掺杂剂离子的无机盐的水/非水溶液，加入0.1-1摩尔含有主体第二组分的无机盐的水/非水溶液 添加5-10重量％的含有pH改性络合剂的水溶液，得到混合物，加热混合物，得到固体层状微结构前体化合物。
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