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公开(公告)号：US20130082216A1
公开(公告)日：2013-04-04
申请号：US13617843
申请日：2012-09-14
申请人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
发明人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
IPC分类号： H01L33/28
CPC分类号： H01L33/285 , C09K11/642 , C30B7/00 , C30B29/16 , C30B29/48 , C30B29/605 , Y10T428/2991
摘要： A single-source solid precursor matrix for semiconductor nanocrystals includes 45-55% by weight of zinc, 28-35% by weight of oxygen, 0.70-1.2% by weight of carbon, 1.5-2.5% by weight of hydrogen, 4-6% by weight of nitrogen, 5-7% by weight of sulphur and 1-5% by weight of dopant ions with respect to the weight of zinc atoms. Doped semiconductor nanocrystals for multicolor displays and bio markers include 60-65% by weight of zinc, 30-32% by weight of sulphur, 1.2-1.3% by weight of copper and 1.2-1.3% by weight of dopant ions.
摘要翻译： 用于半导体纳米晶体的单源固体前体基质包括45-55重量％的锌，28-35重量％的氧，0.70-1.2重量％的碳，1.5-2.5重量％的氢，4-6 相对于锌原子的重量，氮的重量％，5-7重量％的硫和1-5重量％的掺杂剂离子。 用于多色显示器和生物标记物的掺杂半导体纳米晶体包括60-65重量％的锌，30-32重量％的硫，1.2-1.3重量％的铜和1.2-1.3重量％的掺杂剂离子。
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2.发明授权公开(公告)号：US09402918B2
公开(公告)日：2016-08-02
申请号：US14465521
申请日：2014-08-21
IPC分类号： A61K47/48 , A61K9/16 , A61K31/436 , A61K31/44 , A61K31/337 , A61K31/506 , A61K45/06 , A61K9/51 , A61K31/437
CPC分类号： A61K9/167 , A61K9/1635 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/5138 , A61K9/5153 , A61K9/5161 , A61K9/5169 , A61K9/5192 , A61K31/337 , A61K31/436 , A61K31/437 , A61K31/44 , A61K31/506 , A61K31/704 , A61K45/06 , A61K47/6803 , A61K47/6927 , A61K47/6931 , A61K47/6933 , A61K47/6935 , A61K47/6939
摘要： A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, core-shell particle formulation configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enables treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
摘要翻译： 公开了用于递送多种治疗剂的核 - 壳颗粒制剂。 更具体地，构造成独立地从核心和壳体释放治疗剂的核 - 壳颗粒制剂。 此外，具有核壳颗粒的治疗剂能够治疗癌症，炎性和自身免疫性疾病等疾病。
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3.发明申请公开(公告)号：US20140363514A1
公开(公告)日：2014-12-11
申请号：US14465521
申请日：2014-08-21
IPC分类号： A61K47/48 , A61K31/436 , A61K45/06 , A61K31/337 , A61K31/506 , A61K9/16 , A61K31/44
CPC分类号： A61K9/167 , A61K9/1635 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/5138 , A61K9/5153 , A61K9/5161 , A61K9/5169 , A61K9/5192 , A61K31/337 , A61K31/436 , A61K31/437 , A61K31/44 , A61K31/506 , A61K31/704 , A61K45/06 , A61K47/6803 , A61K47/6927 , A61K47/6931 , A61K47/6933 , A61K47/6935 , A61K47/6939
摘要： A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, core-shell particle formulation configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enables treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
摘要翻译： 公开了用于递送多种治疗剂的核 - 壳颗粒制剂。 更具体地，构造成独立地从核心和壳体释放治疗剂的核 - 壳颗粒制剂。 此外，具有核壳颗粒的治疗剂能够治疗癌症，炎性和自身免疫性疾病等疾病。
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公开(公告)号：US20170333365A1
公开(公告)日：2017-11-23
申请号：US15619559
申请日：2017-06-12
IPC分类号： A61K9/51 , A61K31/44 , A61K47/68 , A61K9/00 , A61K31/506 , A61K31/436 , A61K45/06 , A61K31/713 , A61K39/44 , A61K9/16 , A61K38/00 , A61K38/40
摘要： A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, the formulation comprising protein-protein core-shell particle configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enable treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
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5.发明申请FIBROUS BIO-DEGRADABLE POLYMERIC WAFERS SYSTEM FOR THE LOCAL DELIVERY OF THERAPEUTIC AGENTS IN COMBINATIONS 审中-公开用于组合中局部递送治疗药物的纤维生物降解聚合物体系公开(公告)号：US20140363484A1
公开(公告)日：2014-12-11
申请号：US14465642
申请日：2014-08-21
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/7007 , A61K31/175 , A61K31/4188 , A61K31/495 , A61K31/52 , A61K45/06 , A61K47/34 , A61K2300/00
摘要： The present invention is related to flexible, fibrous, biocompatible and biodegradable polymeric wafer; consists of more than one polymeric fibers, each one loaded with different therapeutic agents having mutually exclusive synergistic activity. The wafer is capable of delivering the drugs locally in to the diseased site like tumor, inflammation, wound, etc., in a controlled and sustained fashion for enhanced therapeutic effect. The combination of drugs loaded in the wafer is chosen in such a way that the second or consecutive drugs will enhance or improve the therapeutic effect of the first drug.
摘要翻译： 本发明涉及柔性，纤维，生物相容性和可生物降解的聚合物晶片; 由多于一种的聚合物纤维组成，每个聚合物纤维都装有不同的治疗剂，具有相互排斥的协同作用。 晶片能够以受控和持续的方式将药物局部递送到患病部位，如肿瘤，炎症，伤口等，以增强治疗效果。 选择装载在晶片中的药物的组合使得第二种或连续的药物将增强或改善第一种药物的治疗效果。
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6.发明申请公开(公告)号：US20190167822A1
公开(公告)日：2019-06-06
申请号：US16302565
申请日：2017-05-19
申请人： Manzoor KOYAKUTTY , Vijay Harish SOMASUNDARAM , Anusha ASHOKAN , Shantikumar NAIR , AMRITA VISHWA VIDYAPEETHAM
摘要： The invention discloses non-iodinated radiopaque microbeads that may be used in image guided embolization in a subject ailing with tumor. The non-iodinated radiopaque microbeads include a ceramic material doped with a CT contrast agent or a MRI contrast agent or both. The doped ceramic is blended with a polymer and the blend is electrosprayed to form the radiopaque microbeads. Further the radiopaque microbeads are radiolabeled with a radioactive isotope. Methods of synthesis of the radiopaque microspheres are also disclosed. The non-iodinated radiopaque microbeads with radiolabeling are capable of rendering an imageable computed tomography (CT) contrast or magnetic resonance imaging (MRI) contrast when administered in a subject. Also the microspheres are biodegradable and hence the treatment could be repeated in case of recurrence of the tumor in the subject.
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公开(公告)号：US09707186B2
公开(公告)日：2017-07-18
申请号：US14585013
申请日：2014-12-29
IPC分类号： A61K9/51 , A61K47/48 , A61K9/00 , A61K31/506 , A61K31/436 , A61K31/44 , A61K31/713 , A61K45/06 , A61K38/40 , A61K39/44 , A61K38/00 , A61K9/16
CPC分类号： A61K9/5169 , A61K9/0019 , A61K9/167 , A61K31/436 , A61K31/44 , A61K31/506 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/40 , A61K39/44 , A61K45/06 , A61K47/643 , A61K47/644 , A61K47/645 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6929 , A61K2300/00
摘要： A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, the formulation comprising protein-protein core-shell particle configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enable treatment against the diseases such as cancer, inflammatory and auto-immune diseases.
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公开(公告)号：US20170119803A1
公开(公告)日：2017-05-04
申请号：US15374176
申请日：2016-12-09
IPC分类号： A61K31/704 , A61K9/16 , A61K31/44
CPC分类号： A61K31/704 , A61K31/44 , A61K47/58 , A61K47/643 , A61K47/645 , A61K47/6929 , A61K47/6933 , A61K2300/00
摘要： A formulation for treating a patient with hepatocellular carcinoma is disclosed. The formulation comprises therapeutic agents in the form of nanoparticles containing one or more proteins or polysaccharides. The therapeutic agent is conjugated to an active targeting agent causing the formulation to preferentially segregate to the hepatocellular carcinoma tissue to release the therapeutic agents. Methods of treating hepatocellular carcinoma using the formulations are also disclosed.
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公开(公告)号：US08721926B2
公开(公告)日：2014-05-13
申请号：US13617843
申请日：2012-09-14
申请人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
发明人： Manzoor Koyakutty , Aditya Verma , Sampat Raj Vedera , Narendra Kumar , Thundyil Raman Narayana Kutty
CPC分类号： H01L33/285 , C09K11/642 , C30B7/00 , C30B29/16 , C30B29/48 , C30B29/605 , Y10T428/2991
摘要： A single-source solid precursor matrix for semiconductor nanocrystals includes 45-55% by weight of zinc, 28-35% by weight of oxygen, 0.70-1.2% by weight of carbon, 1.5-2.5% by weight of hydrogen, 4-6% by weight of nitrogen, 5-7% by weight of sulphur and 1-5% by weight of dopant ions with respect to the weight of zinc atoms. Doped semiconductor nanocrystals for multicolor displays and bio markers include 60-65% by weight of zinc, 30-32% by weight of sulphur, 1.2-1.3% by weight of copper and 1.2-1.3% by weight of dopant ions.
摘要翻译： 用于半导体纳米晶体的单源固体前体基质包括45-55重量％的锌，28-35重量％的氧，0.70-1.2重量％的碳，1.5-2.5重量％的氢，4-6 相对于锌原子的重量，氮的重量％，5-7重量％的硫和1-5重量％的掺杂剂离子。 用于多色显示器和生物标记的掺杂半导体纳米晶体包括60-65重量％的锌，30-32重量％的硫，1.2-1.3重量％的铜和1.2-1.3重量％的掺杂离子。
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公开(公告)号：US20120184495A1
公开(公告)日：2012-07-19
申请号：US13377764
申请日：2009-06-12
申请人： Manzoor Koyakutty , Dominic James Robinson , Henricus Johannes Cornelius Maria Sterenborg , Slavka Kascakova , Shantikumar Nair
发明人： Manzoor Koyakutty , Dominic James Robinson , Henricus Johannes Cornelius Maria Sterenborg , Slavka Kascakova , Shantikumar Nair
CPC分类号： A61K41/0071 , A61K47/6923 , A61K47/6939 , A61K49/0019 , A61K49/0067 , A61K49/1827 , A61K49/183 , B82Y5/00
摘要： The present invention relates to a photosensitizer-containing nanoparticle, comprising a photosensitizer covalently bonded throughout at least a part of said nanoparticle to the nanoparticle matrix material and incorporated therein in a quasi-aggregated state. The present invention further relates to methods for producing the invention nanoparticles, and to methods of killing cancer cells by PDT treatment using the said nanoparticles.
摘要翻译： 本发明涉及含有光敏剂的纳米颗粒，其包含共价键合到所述纳米颗粒的至少一部分与纳米颗粒基体材料并且以准聚集状态并入其中的光敏剂。 本发明还涉及制备本发明纳米颗粒的方法，以及通过使用所述纳米颗粒的PDT处理杀死癌细胞的方法。
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