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11.发明授权CGM-based prevention of hypoglycemia via hypoglycemia risk assessment and smooth reduction of insulin delivery 有权通过低血糖风险评估和平滑减少胰岛素输送，基于CGM预防低血糖公开(公告)号：US08562587B2
公开(公告)日：2013-10-22
申请号：US13203469
申请日：2010-02-25
IPC分类号： A61M31/00
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/4839 , A61B5/7275 , A61B5/746 , A61M5/1723 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3468 , G16H40/63 , G16H50/50
摘要： An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
摘要翻译： 本发明的实施方案或部分实施方案的一个方面（或本发明的全部或部分中的各种实施方案的组合）包括但不限于此，用于连续评估所述方法和系统（以及相关的计算机程序产品） 患者出现低血糖风险，然后根据风险评估确定采取什么行动。 进一步的实施例产生两个输出：（1）应用于发送到泵的胰岛素速率指令的衰减因子（通过常规治疗或经由开环或闭环控制）和/或（2）红/黄/ 绿灯低血糖警报为患者提供低血糖风险的指示。 CPHS的两个输出可以组合使用或单独使用。
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12.发明申请Tracking the Probability for Imminent Hypoglycemia in Diabetes From Self-Monitoring Blood Glucose (SMBG) Data 审中-公开追踪自我监测血糖（SMBG）数据在糖尿病中即将发生低血糖的概率公开(公告)号：US20120191361A1
公开(公告)日：2012-07-26
申请号：US13394091
申请日：2010-09-02
申请人： Boris P. Kovatchev , Marc D. Breton
发明人： Boris P. Kovatchev , Marc D. Breton
CPC分类号： G16H50/50 , A61B5/0002 , G01N2800/042
摘要： A method, system and related computer program product for tracking the probability of hypoglycemia from routine self-monitoring of blood glucose (SMBG) data in patients with diabetes. A specific bivariate probability distribution of low BG events based jointly on the Low BG Index (LBGI) and the Average Daily Risk Range (ADRR) is used to predict hypoglycemia probability of occurrence from inputted SMBG data. The SMBG data is retrieved from a series of SMBG data of a patient available from the patient's glucose meter and allows tracking of the probability for future hypoglycemia over a predetermined duration, e.g., a 24 or 48 hour period. The tracking includes presentation of visual and/or numerical output, as we construction of hypoglycemia risk trajectories that would enable warning messages for crossing of predefined thresholds, such as 50% likelihood for upcoming hypoglycemia below 50 mg/dl.
摘要翻译： 一种用于跟踪糖尿病患者血糖（SMBG）数据的常规自我监测低血糖概率的方法，系统及相关计算机程序产品。 低BG指数（LBGI）和平均每日风险范围（ADRR）联合使用的低BG事件的特定双变量概率分布用于预测输入的SMBG数据发生低血糖概率。 从患者血糖仪可获得的患者的一系列SMBG数据中检索SMBG数据，并允许在预定持续时间（例如24或48小时）内追踪未来低血糖的概率。 跟踪包括视觉和/或数字输出的呈现，因为我们构建了低血糖风险轨迹，这将使警告信息能够跨越预定义的阈值，例如低于50mg / dl的低血糖的50％的可能性。
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13.发明申请System Coordinator and Modular Architecture for Open-Loop and Closed-Loop Control of Diabetes 有权糖尿病开环和闭环控制的系统协调器和模块化架构公开(公告)号：US20120078067A1
公开(公告)日：2012-03-29
申请号：US13322943
申请日：2010-05-28
摘要： A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.
摘要翻译： 用于糖尿病控制系统的结构，方法和计算机程序产品提供但不限于以下：适应个体生理特征和适应每个人的行为特征的糖尿病的开环或闭环控制。 这种适应性的一个示例性方面是生物系统（患者或受试者）观察和模块化控制。 因此，建立了模块化系统的基本架构和主要组件，其中可能包括患者行为和代谢状态的算法观察者，以及负责基础速率，胰岛素注射和低血糖预防的相互作用的控制模块。
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14.发明申请CGM-Based Prevention of Hypoglycemia Via Hypoglycemia Risk Assessment and Smooth Reduction of Insulin Delivery 有权通过低血糖风险评估和胰岛素递送平滑减少的基于CGM的低血糖预防公开(公告)号：US20120059353A1
公开(公告)日：2012-03-08
申请号：US13203469
申请日：2010-02-25
IPC分类号： A61M5/168
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/4839 , A61B5/7275 , A61B5/746 , A61M5/1723 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3468 , G16H40/63 , G16H50/50
摘要： An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
摘要翻译： 本发明的实施方案或部分实施方案的一个方面（或本发明的全部或部分中的各种实施方案的组合）包括但不限于此，用于连续评估所述方法和系统（以及相关的计算机程序产品） 患者出现低血糖风险，然后根据风险评估确定采取什么行动。 进一步的实施例产生两个输出：（1）应用于发送到泵的胰岛素速率指令的衰减因子（通过常规治疗或经由开环或闭环控制）和/或（2）红/黄/ 绿灯低血糖警报为患者提供低血糖风险的指示。 CPHS的两个输出可以组合使用或单独使用。
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15.发明申请Method, System and Computer Program Product for Evaluation of Insulin Sensitivity, Insulin/Carbohydrate Ratio, and Insulin Correction Factors in Diabetes from Self-Monitoring Data 审中-公开用于评估胰岛素敏感性，胰岛素/碳水化合物比例的方法，系统和计算机程序产品以及自我监测数据在糖尿病中的胰岛素修正因子公开(公告)号：US20100198520A1
公开(公告)日：2010-08-05
申请号：US12665149
申请日：2008-07-08
申请人： Marc D. Breton , Boris P. Kovatchev
发明人： Marc D. Breton , Boris P. Kovatchev
摘要： A method, system and computer program product for evaluating or determining a user's insulin sensitivity (SI). An initial step or module may include acquiring SMBG readings from a predetermined period. Another step or module may include computing an estimate of insulin sensitivity (SI) from the SMBG readings. Another step or module may include using the estimate of SI to compute individualized carbohydrate ratio. Additionally, another step or module may include using the estimate of SI to compute individualized correction factor. The computation of the two components of an insulin dose calculator, carbohydrate ratio and correction factor, uses this estimate, which allows the tailoring of carbohydrate ratio and correction factor to the present state of the person.
摘要翻译： 一种用于评估或确定用户胰岛素敏感性（SI）的方法，系统和计算机程序产品。 初始步骤或模块可以包括从预定时段获取SMBG读数。 另一个步骤或模块可以包括从SMBG读数计算胰岛素敏感性（SI）的估计。 另一个步骤或模块可以包括使用SI的估计来计算个体化碳水化合物比例。 另外，另一个步骤或模块可以包括使用SI的估计来计算个体化的校正因子。 胰岛素剂量计算器，碳水化合物比例和校正因子的两个组分的计算使用该估计，其允许将碳水化合物比率和校正因子定制为该人的当前状态。
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16.发明申请Method, System, and Computer Program Product for the Detection of Physical Activity by Changes in Heart Rate, Assessment of Fast Changing Metabolic States, and Applications of Closed and Open Control Loop in Diabetes 有权方法，系统和计算机程序产品，用于通过心率变化检测身体活动，快速变化代谢状态的评估以及闭合和开放控制环在糖尿病中的应用公开(公告)号：US20100057043A1
公开(公告)日：2010-03-04
申请号：US12516044
申请日：2007-11-27
申请人： Boris P. Kovatchev , Marc D. Breton
发明人： Boris P. Kovatchev , Marc D. Breton
CPC分类号： A61B5/4839 , A61B5/024 , A61B5/14532 , A61B5/222 , A61B5/4866 , G06F19/00 , G06F19/3456 , G16H50/50
摘要： A method, system, and computer program product related to the detection of physical activity using changes in heart rate. The method, system, and computer program product evaluates short term glucose demand and long term insulin action due to physical activity. The method, system, and computer program product is further related to the improvement of open and closed loop control of diabetes by accounting for the metabolic changes due to physical activity. The method, system, and computer program product is directed to detecting in real time the short and long term effects of physical activity on insulin action via heart rate analysis, and recommending changes in insulin dosing to compensate for the effects of physical activity. With these recommendations, the open and closed loop control of diabetes can be improved and steps can be taken to prevent hypoglycemia that may result from increased insulin sensitivity due to physical activity.
摘要翻译： 与使用心率变化的身体活动检测相关的方法，系统和计算机程序产品。 方法，系统和计算机程序产品评估短期葡萄糖需求和由于身体活动导致的长期胰岛素作用。 方法，系统和计算机程序产品进一步涉及由于身体活动导致的代谢变化，改善糖尿病的开放和闭环控制。 方法，系统和计算机程序产品旨在通过心率分析实时检测身体活动对胰岛素作用的短期和长期影响，并建议胰岛素给药的变化以补偿身体活动的影响。 通过这些建议，可以改善糖尿病的开放和闭环控制，并且可以采取措施来预防由于身体活动而增加的胰岛素敏感性可能导致的低血糖。
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17.发明申请Method and System For The Safety, Analysis and Supervision of Insulin Pump Action and Other Modes of Insulin Delivery in Diabetes 审中-公开胰岛素泵作用及其他胰岛素输送方式在糖尿病中的安全，分析和监督方法与系统公开(公告)号：US20130116649A1
公开(公告)日：2013-05-09
申请号：US13634040
申请日：2011-03-11
IPC分类号： A61M5/168
CPC分类号： A61M5/1684 , A61M5/16836 , G01N33/74 , G01N2333/62 , G01N2800/042 , G06F19/3468
摘要： An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.
摘要翻译： 具有安全性分析和监督功能的胰岛素递送主管（IDS），其可以位于胰岛素需求和胰岛素递送之间，并且可以在胰岛素递送之前截获任何过量的胰岛素请求。 IDS可以在基于胰岛素泵或笔的任何系统中实现，并且可以使用SMBG或CGM模式的血糖监测。
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18.发明申请Method, System and Computer Program Product for Real-Time Detection of Sensitivity Decline in Analyte Sensors 有权方法，系统和计算机程序产品，用于实时检测分析物传感器的灵敏度下降公开(公告)号：US20120173200A1
公开(公告)日：2012-07-05
申请号：US13418305
申请日：2012-03-12
IPC分类号： G06F15/00
CPC分类号： H04B17/00 , A61B5/002 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B2560/0223 , G06F19/3418 , G16H40/67
摘要： Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.
摘要翻译： 提供实时检测分析物传感器灵敏度下降的方法，系统和计算机程序产品是连续的葡萄糖监测系统。
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19.发明申请Method, Computer Program Product and System for Individual Assessment of Alcohol Sensitivity 审中-公开方法，计算机程序产品和酒精敏感性个体评估系统公开(公告)号：US20110264374A1
公开(公告)日：2011-10-27
申请号：US12674348
申请日：2008-08-20
IPC分类号： G06F19/00
CPC分类号： G16B5/00
摘要： Methods/computer methods and systems/computer systems for the evaluation of two idiosyncratic indices of alcohol intoxication: the Alcohol Sensitivity Index (ASI), and the brain-specific Cognitive Alcohol Sensitivity Index (CASI). The two indices are based on the new Metabolic and Cognitive Minimal Models of Alcohol Dynamics, and are derived from specific clinical protocols, accompanied by specific data analysis procedures. The two indices may be derived from specific clinical and cognitive assessment protocols, accompanied by specific data analysis procedures based on the new metabolic and cognitive minimal models of alcohol dynamics.
摘要翻译： 方法/计算机方法和系统/计算机系统，用于评估酒精中毒的两种特异性指标：酒精敏感指数（ASI）和脑特异性认知酒精敏感性指数（CASI）。 这两个指标基于酒精动力学的新型代谢和认知最小模型，并且来自具体的临床方案，并伴有特定的数据分析程序。 这两个指标可能来自特定的临床和认知评估方案，并伴随着基于酒精动力学的新代谢和认知最小模型的特定数据分析程序。
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20.发明申请Method, System and Computer Simulation Environment for Testing of Monitoring and Control Strategies in Diabetes 审中-公开糖尿病监测与控制策略检测方法，系统与计算机仿真环境公开(公告)号：US20100179768A1
公开(公告)日：2010-07-15
申请号：US12664444
申请日：2008-06-20
摘要： A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.
摘要翻译： 1型糖尿病监测方法，开环和闭环治疗策略的电脑测试模拟环境。 模拟环境的一些示例性主要组成部分包括但不限于以下内容：1）在三个年龄组中具有1型糖尿病的计算机“受试者”的“群体” 2）CGM传感器误差的模拟器; 3）胰岛素泵和离散胰岛素输送的模拟器; 4）允许输入用户指定的治疗方案的界面; 和5）一套评估测试治疗策略质量的标准化结果测量和图表。 这些组分可以单独使用或组合使用，用于糖尿病的开环或闭环控制治疗的临床前评估。
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