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公开(公告)号:US20140154940A1
公开(公告)日:2014-06-05
申请号:US14176597
申请日:2014-02-10
申请人: Nevada Naturals Inc.
IPC分类号: A01N37/44
CPC分类号: A01N37/44 , A01N43/38 , A01N43/50 , A01N47/44 , A23B4/20 , A23L3/34635 , A23L3/3508 , A23L3/3526 , A23V2002/00 , B65D81/28 , Y10T428/662 , Y10T442/2525 , A01N47/14 , A01N43/82 , A01N43/40 , A01N37/36 , A01N37/02 , A01N33/12 , A01N37/06 , A01N37/38 , A01N37/40
摘要: A controlled release biocidal salt of a first component comprises a cation of a Nα—(C1-C22) alkanoyl di-basic amino acid alkyl (C1-C22) ester cationic biocidal molecule and a second component comprising an anion of a monomeric anionic molecule having insignificant biocidal activity. The salt is characterized such that when the salt is exposed to an aqueous medium, the salt partially dissolves thereby releasing biocidal ions in an amount sufficient to exceed the MIC or MBC of a target bacteria being controlled, and further characterized as leaving a residual reservoir of undissolved salt capable of releasing more biocidal ions as the salt is consumed or otherwise removed from the environment encompassing the target bacteria. The preferred cationic biocidal molecule comprises Nα-lauroyl-L-arginine ethyl ester (“LAE”).
摘要翻译: 第一组分的控制释放杀生物盐包含Nα-(C1-C22)烷酰基二碱性氨基酸烷基(C1-C22)酯阳离子杀生物分子的阳离子和包含单体阴离子分子的阴离子的第二组分, 不显着的杀生物活性。 盐的特征在于,当盐暴露于水性介质时,盐部分地溶解,由此释放足够超过被控制的目标细菌的MIC或MBC的量的杀生物离子,并且进一步表征为留下残留的储存器 当盐被消耗或从包围目标细菌的环境中除去时,能够释放更多杀生物离子的未溶解的盐。 优选的阳离子杀生物分子包括Nα-月桂酰-L-精氨酸乙酯(“LAE”)。
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公开(公告)号:US20240315250A1
公开(公告)日:2024-09-26
申请号:US18734194
申请日:2024-06-05
申请人: Nevada Naturals Inc.
IPC分类号: A01N47/44 , A01N37/36 , A01N43/16 , A61L15/20 , A61L15/46 , A61L15/60 , A61L17/00 , A61L26/00 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号: A01N47/44 , A01N37/36 , A01N43/16 , A61L15/20 , A61L15/46 , A61L15/60 , A61L17/005 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A01N2300/00 , A61L26/0066 , A61L2300/406 , A61L2400/04
摘要: Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation NαC8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.
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公开(公告)号:US11191274B2
公开(公告)日:2021-12-07
申请号:US16950350
申请日:2020-11-17
申请人: Nevada Naturals Inc.
IPC分类号: A01N47/44 , A01N43/16 , A01N37/36 , A61L31/14 , A61L27/52 , A61L29/16 , A61L15/20 , A61L31/10 , A61L31/16 , A61L29/08 , A61L17/00 , A61L29/14 , A61L27/54 , A61L15/60 , A61L27/34 , A61L15/46 , A61L26/00
摘要: Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation Nα C8-C6 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.
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公开(公告)号:US20210068423A1
公开(公告)日:2021-03-11
申请号:US16950443
申请日:2020-11-17
申请人: NEVADA NATURALS INC.
IPC分类号: A23K30/00 , A23K40/30 , A23K50/42 , A23K20/158 , A23K20/163 , A23B4/20 , A23L3/3517 , A23L3/3526 , A23L3/3562 , A23K20/142
摘要: Methods of making coated pet food kibble and the kibble product by coating kibble with a composition that include at least one of: (i) lecithin and chicken fat; (ii) lecithin, a glycerol monoester of a fatty acid, a sugar monoester of a fatty acid, and chicken fat; (iii) lecithin, Nα—(C8-C18) acyl arginine alkyl (C1-C8) ester, and chicken fat; or (iv) Nα—(C8-C18) acyl arginine alkyl (C1-C8) ester-thymol and chicken fat. When the pet food kibble coated with a composition as described above, exhibits amounts of Salmonella sp. that are reduced by about 99%. This reduction is effective for at least 60 days post coating when compared to pet food kibble coated with a composition lacking one of (i)-(iv). The compositions are also used in a method for treating raw beef or poultry prior to grinding where the ground meat exhibits amounts of Salmonella sp. that are reduced by about 99%.
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公开(公告)号:US20200214320A1
公开(公告)日:2020-07-09
申请号:US16818027
申请日:2020-03-13
申请人: NEVADA NATURALS INC.
IPC分类号: A23K30/00 , A23L3/3562 , A23K40/30 , A23B4/20 , A23K20/163 , A23K20/158 , A23K50/42 , A23L3/3526 , A23K20/142 , A23L3/3517
摘要: Methods of making coated pet food kibble and the kibble product by coating kibble with a composition that include at least one of: (i) lecithin and chicken fat, (ii) lecithin, a glycerol monoester of a fatty acid, a sugar monoester of a fatty acid, and chicken fat; (iii) lecithin, Nα-(C8-C18) acyl arginine alkyl (C1-C8) ester, and chicken fat; or (iv) Nα-(C8-C18) acyl arginine alkyl (C1-C8) ester-thymol and chicken fat. When the pet food kibble coated with a composition as described above, exhibits amounts of Salmonella sp. that are reduced by about 99%. This reduction is effective for at least 60 days post coating when compared to pet food kibble coated with a composition lacking one of (i)-(iv). The compositions are also used in a method for treating raw beef or poultry prior to grinding where the ground meat exhibits amounts of Salmonella sp. that are reduced by about 99%.
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公开(公告)号:US20200107551A1
公开(公告)日:2020-04-09
申请号:US16703397
申请日:2019-12-04
申请人: Nevada Naturals Inc.
IPC分类号: A01N47/44 , A61L31/14 , A61L27/52 , A61L29/16 , A61L15/20 , A61L31/10 , A61L31/16 , A61L29/08 , A61L17/00 , A61L29/14 , A61L27/54 , A61L15/60 , A61L27/34 , A61L15/46 , A01N43/16 , A01N37/36
摘要: Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation NαC8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.
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公开(公告)号:US20200022363A1
公开(公告)日:2020-01-23
申请号:US16335597
申请日:2017-09-21
申请人: Nevada Naturals Inc.
IPC分类号: A01N25/02 , A01N33/12 , A01N47/44 , A01N43/40 , A23L3/3517 , A23L3/3535
摘要: Process for forming controlled release antimicrobial salts that include a four-part mixture of (i) an antimicrobial cation, (ii) the anion of an organic acid, (iii) an ammonium, sodium or potassium cation and (iv) an anion such as a halide, acetate or gluconate, dissolved in a solvent so that a concentrate with dissociated controlled release antimicrobial ions is formed. Upon addition of water, controlled-release antimicrobial salt having a solubility in water at 20° C. of greater than about 0.001 (w/w) %, but less than about 1 (w/w) % are formed. Alternatively, a controlled release antimicrobial salt is formed in situ at a site of application containing moisture by addition of a concentrate having dissociated controlled release antimicrobial ions.
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公开(公告)号:US20140303100A1
公开(公告)日:2014-10-09
申请号:US14314381
申请日:2014-06-25
申请人: Nevada Naturals Inc.
IPC分类号: A61K31/4425 , A61K31/14 , A61K45/06 , A61K31/155
CPC分类号: A61K31/4425 , A61K6/0017 , A61K6/0023 , A61K8/347 , A61K8/43 , A61K8/8135 , A61K31/14 , A61K31/155 , A61K45/06 , A61Q11/00 , C08L33/10 , C08L71/02 , C08L31/04 , C08L29/04
摘要: This invention pertains to dental care compositions with antimicrobial benefits. In particular, the invention provides for compositions of oral tissue-adherent salts that release biocidal ions on a controlled release basis and thereby provide and maintain an essentially uniform concentration of biocidal ions above the MBC or MIC of the target bacteria at the site of application in the mouth for an extended period of time. The compositions are useful for treating or preventing oral diseases resulting from bacteria, fungal or yeast infections, such as caries, gingivitis, periodontal disease and candidiasis.13
摘要翻译: 本发明涉及具有抗菌益处的牙科护理组合物。 特别地,本发明提供了口服组织粘附盐的组合物,其在受控释放的基础上释放杀生物离子,从而在施用位置提供并保持在靶细菌的MBC或MIC上方的基本均匀浓度的杀生物离子浓度 嘴巴长时间的流逝。 该组合物可用于治疗或预防由细菌,真菌或酵母菌感染引起的口腔疾病,例如龋齿,牙龈炎,牙周病和念珠菌病。 13
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公开(公告)号:US20130289111A1
公开(公告)日:2013-10-31
申请号:US13930929
申请日:2013-06-28
申请人: Nevada Naturals Inc.
IPC分类号: A23L3/3526
CPC分类号: A23L3/3526 , A23L3/3508 , A23L3/3544 , C07D209/04 , C07D233/54
摘要: This invention discloses a method of preservation of a food product comprising the step of adding 1) a first component comprising between 10 ppm and 1% of a biocidal salt of Nα-(C1-C22) alkanoyl di-basic amino acid alkyl (C1-C22) ester cationic biocidal molecule with an anionic counterion, and 2) a second component comprising from 10 ppm to 1% by weight an acyl monoglyceride, directly to a food product. The preferred cationic biocidal molecule comprises Nα-lauroyl-L-arginine ethyl ester (“LAE”). The invention also discloses the method of preservation of a food product using salts of a Nα-(C1-C22) alkanoyl di-basic amino acid alkyl (C1-C22) ester cationic biocidal molecule and an anionic counterion with or without a monoglyceride of a fatty acid, whereby the packaging film is compounded with the salts and the optional monoglyceride of a fatty acid.
摘要翻译: 本发明公开了一种保存食品的方法,包括以下步骤:加入1)包含10ppm至1%的Nalpha-(C1-C22)烷酰基二碱性氨基酸烷基(C1- C22)具有阴离子抗衡离子的酯阳离子杀生物分子,和2)包含10ppm至1重量%的酰基单甘油酯的第二组分,直接与食品接触。 优选的阳离子杀生物分子包括Nalpha-月桂酰-L-精氨酸乙酯(“LAE”)。 本发明还公开了使用Nalpha-(C1-C22)烷酰基二碱性氨基酸烷基(C1-C22)酯阳离子杀生物分子的盐和具有或不具有单酸甘油酯的阴离子抗衡离子的食品来保存食品的方法 脂肪酸,由此将包装膜与脂肪酸的盐和任选的甘油单体混合。
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公开(公告)号:US20130231389A1
公开(公告)日:2013-09-05
申请号:US13862684
申请日:2013-04-15
IPC分类号: B65D85/00
摘要: A composition comprising a polymeric material and a preservative combination of 1) a preservative component selected from the salts of Nα—(C1-C18) acyl di-basic amino acid (C1-C18) alkyl ester; 2) a second component selected from a food-safe solvent, food-safe nonionic surfactant or mixtures thereof; and optionally; 3) a third component consisting of an acyl mono-glyceride, wherein the preservative is diffusible from the polymeric material.
摘要翻译: 一种组合物,其包含聚合物材料和防腐剂组合,1)选自Nalpha-(C 1 -C 18)酰基二碱性氨基酸(C 1 -C 18)烷基酯的防腐剂组分; 2)选自食品安全溶剂,食品安全非离子表面活性剂或其混合物的第二组分; 和可选地; 3)由酰基单甘油酯组成的第三组分,其中防腐剂可从聚合物材料扩散。
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