公开(公告)号：US5057538A

公开(公告)日：1991-10-15

申请号：US587147

申请日：1990-09-24

申请人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunoro Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

发明人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunoro Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

IPC分类号： B21B31/16 ,  A61K31/26 ,  A61K31/27 ,  A61K31/275 ,  A61K31/34 ,  A61K31/425 ,  B21B31/02 ,  B21B31/20 ,  B21B33/00 ,  B21B37/18 ,  B21B37/72 ,  C07C253/30 ,  C07C255/34 ,  C07C255/41 ,  C07C255/44 ,  C07C255/53 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/20 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/32 ,  C07D307/33 ,  C07D307/52 ,  C07D307/58 ,  C07D417/12 ,  C09K3/00 ,  C07C121/75

CPC分类号： C07D277/20 ,  B21B31/02 ,  B21B31/203 ,  C07C255/00 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## Wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sub.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O--(R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 --(Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxybenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

公开(公告)号：US4853403A

公开(公告)日：1989-08-01

申请号：US890034

申请日：1986-07-28

申请人： Tadayoshi Shiraishi ,  Naohiro Imai ,  Takeshi Domoto ,  Keiji Kameyama ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kazunori Hosoe ,  Kiyoshi Watanabe

发明人： Tadayoshi Shiraishi ,  Naohiro Imai ,  Takeshi Domoto ,  Keiji Kameyama ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kazunori Hosoe ,  Kiyoshi Watanabe

IPC分类号： C12N9/99 ,  A61K31/10 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61K31/215 ,  A61K31/235 ,  A61K31/275 ,  A61K31/34 ,  A61K31/341 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/415 ,  A61P3/00 ,  A61P11/00 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07C67/00 ,  C07C313/00 ,  C07C317/44 ,  C07C323/16 ,  C07C323/29 ,  C07C323/56 ,  C07C323/65 ,  C07D207/26 ,  C07D207/267 ,  C07D207/38 ,  C07D231/32 ,  C07D231/36 ,  C07D231/56 ,  C07D307/33 ,  C07D307/58

CPC分类号： C07D207/267 ,  C07C323/00 ,  C07D231/32 ,  C07D307/33

摘要： A 3-phenylthiomethylstyrene derivative having the general formula (1): ##STR1## or salt thereof with a base, when X is hydroxyl group, R.sup.1 is hydrogen atom or R.sup.2 is hydrogen atom, a process for preparing the 3-phenylthiomethylstyrene derivative (1), and an antiallergic agent and a tyrosinekinase inhibiting agent containing the 3-phenylthiomethylstyrene derivative (1) as an effective component. The compound (1) of the present invention is a useful intermediate for preparing various organic compounds, and has excellent antiallergic and tyrosinekinase inhibiting activities.

摘要翻译： 具有通式（1）的3-苯基硫代甲基苯乙烯衍生物：其中X为羟基，R 1为氢原子或R 2为氢原子时，其碱为碱的3-苯基硫代甲基苯乙烯 衍生物（1）和含有3-苯基硫代甲基苯乙烯衍生物（1）作为有效成分的抗过敏剂和酪氨酸激酶抑制剂。 本发明的化合物（1）是制备各种有机化合物的有用的中间体，具有优异的抗过敏和酪氨酸激酶抑制活性。