公开(公告)号：US07622146B2

公开(公告)日：2009-11-24

申请号：US11592632

申请日：2006-11-02

Applicant: Wouter E. Roorda ,  Syed F. A. Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen D. Pacetti

Inventor： Wouter E. Roorda ,  Syed F. A. Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen D. Pacetti

IPC: A61L33/00 ,  A61M25/00 ,  A61F2/06

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  A61L2420/08

Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.

Abstract translation: 公开了一种涂覆可植入医疗装置（例如支架）的方法。 该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。 制剂可以含有高度疏水性的聚合物或作为第一层的药物或聚合物的不良溶剂的溶剂。 制剂可以具有低表面张力值或高Weber数值。

公开(公告)号：US07563780B1

公开(公告)日：2009-07-21

申请号：US10871658

申请日：2004-06-18

Applicant: Syed Faiyaz Ahmed Hossainy ,  Ni Ding

Inventor： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

IPC: C08B37/10 ,  A61K31/727 ,  A61P7/02

CPC classification number: A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：US07504125B1

公开(公告)日：2009-03-17

申请号：US10040538

申请日：2001-12-28

Applicant: Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

Inventor： Stephen D. Pacetti ,  Wouter E. Roorda ,  Ni Ding

IPC: B05D3/04

CPC classification number: B05D3/0466 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D3/0473 ,  B05D3/048 ,  Y10T428/1393 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31855

Abstract: A method and system of coating an implantable device, such as a stent, are provided.

Abstract translation: 提供涂覆可植入装置（例如支架）的方法和系统。

公开(公告)号：US07396541B2

公开(公告)日：2008-07-08

申请号：US11228420

申请日：2005-09-15

Applicant: Syed Faiyaz Ahmed Hossainy ,  Ni Ding

Inventor： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

IPC: A61F2/00

CPC classification number: A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供了包含肝素和药物的前药。 前药可用于在医疗装置上形成涂层。 前药还可以与聚合物材料一起使用以在医疗装置上形成涂层。 聚合物材料可以是疏水性聚合物，亲水性聚合物，非结垢聚合物，或其组合。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：US20070299509A1

公开(公告)日：2007-12-27

申请号：US11851675

申请日：2007-09-07

Applicant: Ni DING

Inventor： Ni DING

IPC: A61F2/06

CPC classification number: A61F2/82 ,  A61F2/07 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42

Abstract: The medical devices of the invention comprise a portion having a porous surface for release of at least one biologically active agent therefrom. The porous surface is made of a material such as a polymer having a plurality of voids. To load the porous surface with a biologically active agent or drug, an electrophoresis method is employed. In this method, a device having a porous surface is placed into a drug solution or suspension, along with an electrode. An electric current is applied to the device and electrode. Under such a current, the drug, which has a positive or negative charge, will be loaded into the pores or voids of the porous surface.

Abstract translation: 本发明的医疗装置包括具有用于从其释放至少一种生物活性剂的多孔表面的部分。 多孔表面由诸如具有多个空隙的聚合物的材料制成。 为了用生物活性剂或药物加载多孔表面，使用电泳方法。 在该方法中，具有多孔表面的装置与电极一起放入药液或悬浮液中。 电流被施加到器件和电极上。 在这样的电流下，具有正电荷或负电荷的药物将被加载到多孔表面的孔或空隙中。

公开(公告)号：US07294329B1

公开(公告)日：2007-11-13

申请号：US10199272

申请日：2002-07-18

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61K51/00 ,  A61M36/14

CPC classification number: A61K31/573 ,  A61K31/436 ,  A61K47/6957 ,  Y10T428/31855

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer.

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层包括聚缩醛基聚合物。

公开(公告)号：US07285304B1

公开(公告)日：2007-10-23

申请号：US10603889

申请日：2003-06-25

Applicant: Syed F. A. Hossainy ,  Ni Ding ,  Stephen D. Pacetti

Inventor： Syed F. A. Hossainy ,  Ni Ding ,  Stephen D. Pacetti

IPC: A61L33/00

CPC classification number: A61L31/10 ,  A61F2/91 ,  A61F2210/0004 ,  Y10S623/901

Abstract: A method of manufacturing an implantable medical device including applying a composition to an implantable medical device, the composition including a polymer, an active agent and a solvent; allowing the solvent to evaporate to form a dry coating, the dry coating comprising less than about 2% residual fluid content (w/w); applying a fluid to the dry coating, the fluid being substantially free from any polymer; and allowing the fluid to evaporate from the coating.

Abstract translation: 一种制造可植入医疗装置的方法，包括将组合物施用于可植入医疗装置，所述组合物包括聚合物，活性剂和溶剂; 允许溶剂蒸发以形成干燥涂层，干涂层包含小于约2％的残留流体含量（w / w）; 将流体施加到干燥涂层，所述流体基本上不含任何聚合物; 并允许流体从涂层蒸发。

公开(公告)号：US20060073183A1

公开(公告)日：2006-04-06

申请号：US11282849

申请日：2005-11-17

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61K31/727 ,  A61K31/4745 ,  A61K31/337 ,  A61K6/083

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/606 ,  C08L5/08 ,  C08L5/10 ,  C08L71/02

Abstract: A therapeutic composition is provided including a polysaccharide or a cationic peptide dissolved in an organic substance. The polysaccharide can be heparin or a derivative of heparin. The cationic peptide can be L-arginine, oligo-L-arginine or poly-L-arginine. The organic substance can be formamide. A method of coating an implantable medical device is also provided, comprising applying the therapeutic composition to the device and allowing the organic substance to evaporate. The device can be a stent.

Abstract translation: 提供了包含溶解在有机物质中的多糖或阳离子肽的治疗组合物。 多糖可以是肝素或肝素的衍生物。 阳离子肽可以是L-精氨酸，寡聚-L-精氨酸或聚-L-精氨酸。 有机物可以是甲酰胺。 还提供了涂覆可植入医疗装置的方法，包括将该治疗组合物施用于该装置并允许有机物质蒸发。 该装置可以是支架。

公开(公告)号：US07022334B1

公开(公告)日：2006-04-04

申请号：US10104179

申请日：2002-03-20

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/606 ,  C08L5/08 ,  C08L5/10 ,  C08L71/02

Abstract: A therapeutic composition is provided including a polysaccharide or a cationic peptide dissolved in an organic substance. The polysaccharide can be heparin or a derivative of heparin. The cationic peptide can be L-arginine, oligo-L-arginine or poly-L-arginine. The organic substance can be formamide. A method of coating an implantable medical device is also provided, comprising applying the therapeutic composition to the device and allowing the organic substance to evaporate. The device can be a stent.

公开(公告)号：US20050208200A1

公开(公告)日：2005-09-22

申请号：US11116052

申请日：2005-04-27

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61F2/00 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61K9/00 ,  A61K47/32 ,  A61K47/34 ,  A61L27/00 ,  A61L27/22 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/10 ,  A61M37/00 ,  A61F2/06

CPC classification number: A61L33/0011 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/08 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  C08L83/08 ,  C08L71/02 ,  C08L5/00 ,  C08L83/00 ,  C08L83/04

Abstract: A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

Abstract translation: 公开了用于涂覆可植入装置或假体的涂层和方法。 该涂层包括聚合材料的底涂层，其中含有一定量的分散在其中的生物活性材料，特别是肝素。 涂层还包括覆盖低于底涂层整个表面的面漆，并且其中面漆包含基本上不含孔隙和孔隙体的聚合材料。 面漆的聚合材料可以是生物稳定的生物相容性材料，其在生物活性材料释放过程中和之后提供了对器件部分的长期非血栓形成。