公开(公告)号：US06398800B2

公开(公告)日：2002-06-04

申请号：US09884520

申请日：2001-06-18

Applicant: Peng-Sheng Chen

Inventor： Peng-Sheng Chen

IPC: A61N100

CPC classification number: A61N1/385 ,  A61N1/36114 ,  A61N1/3956

Abstract: A method is described for increasing the likelihood of the occurrence of an arrhythmia in a heart, particularly a ventricular arrhythmia of the type leading to Sudden Cardiac Death. The method includes the steps of creating an atrioventricular block in the heart of an animal test subject, inducing a myocardial infarction in the heart of the test subject, and then stimulating myocardial hyperinnervation the test subject. In a specific example described herein, the atrioventricular block is created by ablating the atrioventricular node of the heart using an ablation catheter. The myocardial infarction is induced by ligating the left anterior descending portion of the coronary artery. Myocardial hyperinnervation is stimulated by application of Nerve Growth Factor or other neurotrophic vectors to the left stellate ganglion. The test subject is an adult canine. By creating an atrioventricular block and a myocardial infarction within the heart of an adult canine test subject, then stimulating nerve growth within the left stellate ganglion of the subject using Nerve Growth Factor, it has been found that there is a significant increase in the likelihood of Sudden Cardiac Death arising from ventricular arrhythmias. It is believed that the Sudden Cardiac Death of the test subject arises in a manner very similar to circumstances wherein Sudden Cardiac Death occurs in human patients subject to a previous myocardial infarction, thus, an animal model system for artificially inducing a heart arrhythmia is also disclosed. Thus, the method and animal model system facilitate the collection of data pertinent to conditions within the heart arising prior to Sudden Cardiac Death and for developing and testing therapies intended to prevent Sudden Cardiac Death.

Abstract translation: 描述了一种用于增加心脏中发生心律失常的可能性的方法，特别是导致突发性心脏死亡的类型的室性心律失常。 该方法包括以下步骤：在动物测试对象的心脏中产生房室传导阻滞，在测试对象的心脏中诱发心肌梗死，然后刺激心脏超嗜化的测试对象。 在本文所述的具体示例中，通过使用消融导管消融心脏房室结而产生房室传导阻滞。 通过结扎冠状动脉的左前降支部分诱导心肌梗塞。 通过将神经生长因子或其他神经营养载体应用于左星状神经节来刺激心肌过度增生。 测试对象是成年犬。 通过在成年犬试验对象的心脏内产生房室传导阻滞和心肌梗塞，然后使用神经生长因子刺激受试者的左星状神经节内的神经生长，已经发现，可能性显着增加 心室心跳骤停引起心室心律失常。 据信，测试对象的突发性心脏死亡以非常类似于在先前心肌梗塞的人类患者中发生突发性心脏死亡的情况的方式产生，因此，还公开了人造诱发心律失常的动物模型系统 。 因此，方法和动物模型系统有助于收集与突发性心脏死亡之前产生的心脏内的情况相关的数据，并开发和测试旨在预防突发性心脏死亡的疗法。

公开(公告)号：US5564422A

公开(公告)日：1996-10-15

申请号：US415369

申请日：1995-04-03

Applicant: Peng-Sheng Chen ,  Charles D. Swerdlow

Inventor： Peng-Sheng Chen ,  Charles D. Swerdlow

IPC: A61N1/38 ,  A61N1/39

CPC classification number: A61N1/385 ,  A61N1/3925

Abstract: A system and method for predicting the defibrillation threshold energy of a defibrillation lead arrangement by determining the upper limit of vulnerability of the heart by shocking the heart at varying times during the T-wave at decreasing test shock energy levels until fibrillation is induced in the heart. The lowest energy level which fails to induce fibrillation is determined to be the upper limit of vulnerability and the defibrillation threshold is predicted to be an energy level incrementally higher in the range of about 5 Joules.

Abstract translation: 一种用于通过在降低测试冲击能量水平的T波期间的不同时间通过震动心脏来确定心脏脆弱性的上限来预测除颤引导装置的除颤阈值能量的系统和方法，直到在心脏中引发颤动 。 不能诱发原纤维化的最低能量水平被确定为脆弱性的上限，预计除颤阈值是在5焦耳范围内逐渐增加的能量水平。

公开(公告)号：US09375161B2

公开(公告)日：2016-06-28

申请号：US13127617

申请日：2009-10-28

Applicant: Peng-Sheng Chen ,  Shien-Fong Lin

Inventor： Peng-Sheng Chen ,  Shien-Fong Lin

IPC: A61M5/00 ,  A61B5/04 ,  A61B5/00 ,  A61N1/362 ,  A61N1/39

CPC classification number: A61B5/04001 ,  A61B5/6846 ,  A61N1/3624 ,  A61N1/395

Abstract: A method has been developed that detects cardiac arrhythmia from intrinsic cardiac nerve signals obtained from a heart in a patient. The method includes sampling intrinsic cardiac nerve activity at a high sample rate, filtering the sampled signal with a high pass filter, comparing the filtered signal to a predetermined threshold, and initiating a therapeutic action in response to the filtered signal exceeding the predetermined threshold. The intrinsic cardiac nerve activity may be received through an electrode implanted on the heart or from an electrode inserted into the venous structure of the heart.

Abstract translation: 已经开发了一种从患者心脏获得的内在心脏神经信号中检测心律失常的方法。 该方法包括以高采样率对固有的心脏神经活动进行采样，用高通滤波器对采样信号进行滤波，将滤波的信号与预定的阈值进行比较，以及响应于经过滤波的信号超过预定阈值启动治疗动作。 可以通过植入在心脏上的电极或插入到心脏静脉结构中的电极来接收固有的心脏神经活动。

公开(公告)号：US20130190586A1

公开(公告)日：2013-07-25

申请号：US13877210

申请日：2011-10-06

Applicant: A. George Akingba ,  Peng-Sheng Chen ,  Aamer Mahmood

Inventor： A. George Akingba ,  Peng-Sheng Chen ,  Aamer Mahmood

IPC: A61B5/04 ,  A61N1/05

CPC classification number: A61B5/04001 ,  A61B2562/0215 ,  A61B2562/0285 ,  A61B2562/046 ,  A61B2562/125 ,  A61H39/002 ,  A61H39/08 ,  A61H2230/085 ,  A61N1/0551

Abstract: An electrode for monitoring nerve activity has been developed. The electrode includes an array of electrically conductive projections extending from a surface of an electrical contact that enable the electrical contact to be connected directly to the nerve.

Abstract translation: 已经开发了用于监测神经活动的电极。 电极包括从电触头的表面延伸的导电突起的阵列，其使得电触头能够直接连接到神经。

公开(公告)号：US20090094606A1

公开(公告)日：2009-04-09

申请号：US11905782

申请日：2007-10-04

Applicant: Peng-Sheng Chen ,  Fu-Shun Chu

Inventor： Peng-Sheng Chen ,  Fu-Shun Chu

IPC: G06F9/46

CPC classification number: G06F9/4881 ,  G06F17/2247 ,  G06F17/227

Abstract: An XSLT method is used in a multi-thread environment. In the XSLT method, an XML file is analyzed in view of XSLT templates. Relationships between the transforming processes of the XSLT templates and the tree nodes of the XML file are built. Time for the execution of the transforming process of each of the XSLT templates and the number of a related one of the tree nodes are calculated. Threads are scheduled for the transforming processes of the XSLT templates. The transforming processes of the XSLT templates are executed.

Abstract translation: 在多线程环境中使用XSLT方法。 在XSLT方法中，根据XSLT模板分析XML文件。 构建XSLT模板的转换过程与XML文件的树节点之间的关系。 计算用于执行每个XSLT模板的转换处理的时间和相关的一个树节点的数量。 线程被安排用于XSLT模板的转换过程。 执行XSLT模板的转换过程。

公开(公告)号：US20060074451A1

公开(公告)日：2006-04-06

申请号：US11205923

申请日：2005-08-16

Applicant: Peng-Sheng Chen ,  Shengmei Zhou

Inventor： Peng-Sheng Chen ,  Shengmei Zhou

IPC: A61N1/36

CPC classification number: A61B5/4094 ,  A61B5/04001 ,  A61B5/4035 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/362 ,  A61N1/3702 ,  A61N1/37258 ,  A61N1/37282

Abstract: Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.

Abstract translation: 提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性增加与患者交感神经放电升高相关。 方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。 所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。 可用于与递送有关的药理学试剂包括已知能发挥抗心律不齐作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。 其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

公开(公告)号：US20150297104A1

公开(公告)日：2015-10-22

申请号：US14649038

申请日：2013-12-09

Applicant: Peng-Sheng CHEN ,  Shien-Fong LIN

Inventor： Peng-Sheng Chen ,  Shien-Fong Lin

IPC: A61B5/04 ,  A61B5/046 ,  A61N1/39 ,  A61B5/00 ,  A61N1/365 ,  A61B5/044 ,  A61B5/0245

Abstract: A system and method for monitoring nerve activity in a subject. The system includes a plurality of electrodes placed in proximity to skin of the subject, an amplifier electrically connected to the electrodes and configured to generate a plurality of amplified signals corresponding to electrical signals received from the subject through the electrodes, and a signal processor. The signal processor applies a high-pass filter to the amplified signals to generate filtered signals from the amplified signals, identifies autonomic nerve activity in the plurality of filtered signals; and generates an output signal corresponding to the filtered signals. The high-pass filter attenuates a plurality of the amplified signals having frequencies that correspond to heart muscle activity during a heartbeat.

Abstract translation: 用于监测受试者的神经活动的系统和方法。 该系统包括放置在受试者皮肤附近的多个电极，电连接到电极并被配置为产生对应于通过电极从对象接收的电信号的多个放大信号的放大器和信号处理器。 信号处理器对放大的信号应用高通滤波器以从放大信号产生滤波信号，识别多个滤波信号中的自主神经活动; 并产生对应于滤波信号的输出信号。 高通滤波器衰减在心跳期间具有与心肌活动相对应的频率的多个放大信号。

公开(公告)号：US20130087757A1

公开(公告)日：2013-04-11

申请号：US13339342

申请日：2011-12-28

Applicant: Wei-Su Chen ,  Frederick T. Chen ,  Shan-Yi Yang ,  Peng-Sheng Chen

Inventor： Wei-Su Chen ,  Frederick T. Chen ,  Shan-Yi Yang ,  Peng-Sheng Chen

IPC: H01L45/00 ,  H01L21/62

CPC classification number: H01L45/04 ,  H01L27/2409 ,  H01L27/2463 ,  H01L27/2481 ,  H01L45/1233 ,  H01L45/145 ,  H01L45/146 ,  H01L45/1616 ,  H01L45/1625 ,  H01L45/1691

Abstract: A method of manufacturing a resistive memory device is provided. A bottom electrode and a cup-shaped electrode connected to the bottom electrode are formed in an insulating layer. A cover layer extends along a first direction is formed and covers a first area surrounded by the cup-shaped electrode and exposes a second area and a third area surrounded by the cup-shaped electrode. A sacrificial layer is formed above the insulating layer. A stacked layer extends along a second direction and covers the second area surrounded by the cup-shaped electrode and a portion of the corresponding cover layer is formed. A conductive spacer material layer is formed on the stacked layer and the sacrificial layer. By using the sacrificial layer as an etch stop layer, the conductive spacer material layer is etched to form a conductive spacer at the sidewall of the stacked layer.

Abstract translation: 提供一种制造电阻式存储器件的方法。 连接到底部电极的底部电极和杯形电极形成在绝缘层中。 形成沿着第一方向延伸的覆盖层，并且覆盖由杯状电极包围的第一区域，并露出由杯状电极包围的第二区域和第三区域。 在绝缘层之上形成牺牲层。 堆叠层沿着第二方向延伸并且覆盖由杯形电极包围的第二区域，并且形成相应覆盖层的一部分。 导电间隔物层形成在堆叠层和牺牲层上。 通过使用牺牲层作为蚀刻停止层，蚀刻导电间隔物材料层，以在堆叠层的侧壁处形成导电间隔物。

公开(公告)号：US07822474B2

公开(公告)日：2010-10-26

申请号：US11606636

申请日：2006-11-29

Applicant: Peng-Sheng Chen

Inventor： Peng-Sheng Chen

IPC: A61N1/00

CPC classification number: G01N33/6893 ,  A61N1/362 ,  G01N2333/48 ,  G01N2800/32

Abstract: Methods and kits are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart. The methods and kits comprise measuring serum NGF levels in a subject and detecting increases in NGF levels over baseline. The methods may further comprise initiating preventive therapy in response to a detected increase in serum NGF levels.

Abstract translation: 提供了方法和试剂盒，用于确定心律不齐，心肌缺血，充血性心力衰竭和心脏其他患病状况发生的可能性增加。 方法和试剂盒包括测量受试者的血清NGF水平，并检测NGF水平超过基线的增加。 所述方法还可以包括响应于检测到的血清NGF水平的增加而启动预防性治疗。

公开(公告)号：US06351668B1

公开(公告)日：2002-02-26

申请号：US09307230

申请日：1999-05-07

Applicant: Peng-Sheng Chen

Inventor： Peng-Sheng Chen

IPC: A61N100

CPC classification number: A61N1/385 ,  A61N1/36114 ,  A61N1/3956

Abstract: A method is described for increasing the likelihood of the occurrence of an arrhythmia in a heart, particularly a ventricular arrhythmia of the type leading to Sudden Cardiac Death. The method includes the steps of creating an atrioventricular block in the heart of an animal test subject, inducing a myocardial infarction in the heart of the test subject, and then stimulating myocardial hyperinnervation the test subject. In a specific example described herein, the atrioventricular block is created by ablating the atrioventricular node of the heart using an ablation catheter. The myocardial infarction is induced by ligating the left anterior descending portion of the coronary artery. Myocardial hyperinnervation is stimulated by application of Nerve Growth Factor or other neurotrophic vectors to the left stellate ganglion. The test subject is an adult canine. By creating an atrioventricular block and a myocardial infarction within the heart of an adult canine test subject, then stimulating nerve growth within the left stellate ganglion of the subject using Nerve Growth Factor, it has been found that there is a significant increase in the likelihood of Sudden Cardiac Death arising from ventricular arrythmias. It is believed that the Sudden Cardiac Death of the test subject arises in a manner very similar to circumstances wherein Sudden Cardiac Death occurs in human patients subject to a previous myocardial infarction, thus, an animal model system for artificially inducing a heart arrhythmia is disclosed. Thus, the method and animal model system facilitate the collection of data pertinent to conditions within the heart arising prior to Sudden Cardiac Death and for developing and testing therapies intended to prevent Sudden Cardiac Death.

Abstract translation: 描述了一种用于增加心脏中发生心律失常的可能性的方法，特别是导致突发性心脏死亡的类型的室性心律失常。 该方法包括以下步骤：在动物测试对象的心脏中产生房室传导阻滞，在测试对象的心脏中诱发心肌梗死，然后刺激心脏超嗜化的测试对象。 在本文所述的具体示例中，通过使用消融导管消融心脏房室结而产生房室传导阻滞。 通过结扎冠状动脉的左前降支部分诱导心肌梗塞。 通过将神经生长因子或其他神经营养载体应用于左星状神经节来刺激心肌过度增生。 测试对象是成年犬。 通过在成年犬试验对象的心脏内产生房室传导阻滞和心肌梗塞，然后使用神经生长因子刺激受试者的左星状神经节内的神经生长，已经发现，可能性显着增加 心室心律失常引起的心脏骤停。 相信测试对象的突发性心脏死亡以与之前发生心肌梗塞的人类患者发生突然的心脏死亡的情况非常相似的方式产生，因此，公开了人造诱发心律失常的动物模型系统。 因此，方法和动物模型系统有助于收集与突发性心脏死亡之前产生的心脏内的情况相关的数据，并开发和测试旨在预防突发性心脏死亡的疗法。