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![Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors](/abs-image/US/2009/01/22/US20090023745A1/abs.jpg.150x150.jpg)
11.发明申请Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors 有权取代的吡唑并[4,3-c]吡啶衍生物作为激酶抑制剂公开(公告)号：US20090023745A1
公开(公告)日：2009-01-22
申请号：US12096979
申请日：2006-12-06
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
IPC分类号： A61K31/496 , C07D471/04 , C07K14/71 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04
摘要： Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如本说明书中定义的式（I）的吡唑并[4,3-c]吡啶衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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公开(公告)号：US08993556B2
公开(公告)日：2015-03-31
申请号：US13264888
申请日：2010-04-16
IPC分类号： C07D231/14 , C07D261/14 , C07D261/18 , C07D413/12 , C07D413/14 , C07D453/02 , A61K31/42 , A61K31/454 , A61K31/439 , A61K31/496 , A61K31/5377
CPC分类号： C07D231/14 , C07D261/14 , C07D261/18 , C07D413/12 , C07D413/14 , C07D453/02
摘要： The present invention relates to substituted resorcinol derivatives which inhibit the activity of Heat Shock Protein HSP90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, pharmaceutical compositions comprising them, methods of treating diseases and the pharmaceutical compositions comprising these compounds.
摘要翻译： 本发明涉及抑制热休克蛋白HSP90活性的取代间苯二酚衍生物。 因此，本发明的化合物可用于治疗增殖性疾病如癌症和神经变性疾病。 本发明还提供了制备这些化合物的方法，包含它们的药物组合物，治疗疾病的方法和包含这些化合物的药物组合物。
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13.发明授权Pyrazolo quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑喹啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08541429B2
公开(公告)日：2013-09-24
申请号：US12262933
申请日：2008-10-31
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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![SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS](/abs-image/US/2011/09/22/US20110230470A1/abs.jpg.150x150.jpg)
14.发明申请SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS 有权作为激酶抑制剂活性的取代的吡唑并[4,3-C]吡啶衍生物公开(公告)号：US20110230470A1
公开(公告)日：2011-09-22
申请号：US13085889
申请日：2011-04-13
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
IPC分类号： A61K31/551 , A61K31/496 , A61K31/437 , A61K31/5377 , A61P35/00 , A61P31/12 , A61P27/02 , A61P9/10 , A61P17/06 , A61P11/00 , A61P3/04 , A61P35/04 , A61P19/02 , A61P9/00 , A61P29/00 , A61N5/00
CPC分类号： C07D471/04
摘要： Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如本说明书中定义的式（I）的吡唑并[4,3-c]吡啶衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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![Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors](/abs-image/US/2011/05/24/US07947686B2/abs.jpg.150x150.jpg)
15.发明授权Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors 有权作为激酶抑制剂活性的取代的吡唑并[4,3-c]吡啶衍生物公开(公告)号：US07947686B2
公开(公告)日：2011-05-24
申请号：US12096979
申请日：2006-12-06
申请人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
发明人： Tiziano Bandiera , Andrea Lombardi Borgia , Paolo Polucci , Manuela Villa , Marcella Nesi , Mauro Angiolini , Mario Varasi
IPC分类号： A61K31/496 , A61K31/437 , C07D401/14 , C07D471/04
CPC分类号： C07D471/04
摘要： Substituted pyrazolo[4,3-c]pyridine derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer.
摘要翻译： 公开了如本说明书中定义的式（I）的吡唑并[4,3-c]吡啶衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病如癌症。
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16.发明申请公开(公告)号：US20110118278A1
公开(公告)日：2011-05-19
申请号：US12991564
申请日：2009-05-14
申请人： Maurizio Pulici , Paolo Polucci
发明人： Maurizio Pulici , Paolo Polucci
IPC分类号： A61K31/496 , C07D401/14 , C07D401/12 , C07D495/04 , A61K31/4162 , A61K31/454 , A61P35/00
CPC分类号： A61K31/496 , A61K31/4162 , A61K31/454 , C07D231/56 , C07D471/04 , C07D487/04 , C07D497/04
摘要： There are provided bicyclic carbonylamino-pyrazoles of formula (I), wherein the variables are as specified in the claims, for use as medicament, in particular for the treatment of diseases due to the malfunctioning of protein kinases (PKs), such as cancer, pharmaceutical compositions comprising such carbamoyl derivatives, and their use as prodrugs of therapeutically active agents. Method of treatment and some new bicyclic carbonylamino-pyrazoles are also object of the present invention.
摘要翻译： 提供式（I）的双环羰基氨基 - 吡唑，其中变量如权利要求中所述，用作药物，特别是用于治疗由于蛋白激酶（PK）（例如癌症）的功能障碍引起的疾病， 包含这种氨基甲酰基衍生物的药物组合物及其作为治疗活性剂前药的用途。 治疗方法和一些新的双环羰基氨基 - 吡唑也是本发明的目的。
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17.发明申请Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其用作激酶抑制剂公开(公告)号：US20090124605A1
公开(公告)日：2009-05-14
申请号：US12262933
申请日：2008-10-31
申请人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A61K31/551 , A61K31/519 , C12N9/99 , C07D487/04 , A61K31/496 , A61P25/28 , A61P17/06 , A61P37/06 , A61P37/00 , A61P35/00 , C07D401/14 , C07D413/14 , A61K31/5377
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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18.发明申请Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US20070185143A1
公开(公告)日：2007-08-09
申请号：US10557565
申请日：2004-04-27
申请人： Gabriella Traquandi , Maria Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
发明人： Gabriella Traquandi , Maria Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC分类号： A61K31/505
CPC分类号： C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention maybe useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer”.
摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与抑制性蛋白激酶活性相关的疾病如癌症“。
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