公开(公告)号：US6051711A

公开(公告)日：2000-04-18

申请号：US188164

申请日：1998-10-23

Applicant: Francois Tropper ,  Rajan N. Shah ,  Pradeep Sharma

Inventor： Francois Tropper ,  Rajan N. Shah ,  Pradeep Sharma

IPC: A61K31/437 ,  A61P43/00 ,  C07D317/30 ,  C07D471/04 ,  C07D491/056 ,  C07D491/14 ,  C07D491/147 ,  C07D491/18 ,  C07D317/10

CPC classification number: C07D471/04 ,  C07D317/30 ,  C07D491/14

Abstract: A method for synthesizing swainsonine salts and intermediates thereof comprising subjecting a compound of the formula I ##STR1## wherein R.sup.2 and R.sup.2' are the same or different and represent alkyl, halogen, alkenyl, alkoxy, cycloalkyl or aryl which may be substituted, to acid hydrolysis in the presence of a C.sub.1-4 alkanol to obtain a crystalline salt of swainsonine; and optionally, recrystallizing the swainsonine salt from a C.sub.1-4 alkanol. The reaction may be used in combination with one or more additional reaction steps.

Abstract translation: 一种合成磺胺酸盐的方法及其中间体，其包括使其中R2和R2'相同或不同并表示可被取代的烷基，卤素，烯基，烷氧基，环烷基或芳基的式I化合物在 存在C 1-4链烷醇以获得磺胺酸的结晶盐; 并且任选地，从C 1-4链烷醇中重结晶磺酸盐。 该反应可以与一个或多个另外的反应步骤组合使用。

公开(公告)号：US09957157B2

公开(公告)日：2018-05-01

申请号：US11857967

申请日：2007-09-19

Applicant: Gemunu H. Gunaratne ,  Girish Nathan ,  Donald J. Kouri ,  Pradeep Sharma ,  Fazle Hussain ,  Feng Shi

Inventor： Gemunu H. Gunaratne ,  Girish Nathan ,  Donald J. Kouri ,  Pradeep Sharma ,  Fazle Hussain ,  Feng Shi

IPC: B81C1/00 ,  B82Y30/00

CPC classification number: B81C1/00031 ,  B81C2201/0149 ,  B82Y30/00 ,  Y10T428/24628

Abstract: A new approach to fabricating regularly patterned nano-scale structures, by self assembly of the structures is disclosed, where a pattern of nano-lines are deposited on a substrate and nano-structures are grown by self assembly in regions between the lines to form regular or patterned nano-scale structures, which are ideally suited for the construction nano-scale materials, nano-scale electronic devices and other nano-scale objects, apparatuses or devices. The invention also relates to methods of making and using same.

公开(公告)号：US08969827B2

公开(公告)日：2015-03-03

申请号：US13544019

申请日：2012-07-09

Applicant: Yong-Fen Hsieh ,  Chih-Hsun Chu ,  Pradeep Sharma ,  Yu-Feng Ko ,  Chung-Shi Yang ,  Lin-Ai Tai ,  Yu-Ching Chen

Inventor： Yong-Fen Hsieh ,  Chih-Hsun Chu ,  Pradeep Sharma ,  Yu-Feng Ko ,  Chung-Shi Yang ,  Lin-Ai Tai ,  Yu-Ching Chen

IPC: B82Y35/00 ,  G01N1/40 ,  G01N23/02 ,  G01N33/49

CPC classification number: H01J37/261 ,  B01L3/508 ,  B01L2200/0678 ,  B01L2300/0822 ,  G01N1/28 ,  G01N1/4022 ,  G01N23/02 ,  G01N2001/4027 ,  H01J37/16 ,  H01J37/20 ,  H01J37/222 ,  H01J37/3178 ,  H01J2237/2007 ,  H01J2237/2602 ,  H01J2237/2802

Abstract: A specimen kit having a tiny chamber is disclosed for a specimen preparation for TEM. The space height of the chamber is far smaller than dimensions of blood cells and therefore is adapted to sort nanoparticles from the blood cells. The specimen prepared under this invention is suitable for TEM observation over a true distribution status of nanoparticles in blood. The extremely tiny space height in Z direction eliminates the possibility of aggregation of the nanoparticles and/or agglomeration in Z direction during drying; therefore, a specimen prepared under this invention is suitable for TEM observation over the dispersion and/or agglomeration of nanoparticles in a blood.

Abstract translation: 公开了一种用于TEM的样品制备的具有微小室的标本试剂盒。 室的空间高度远小于血细胞的尺寸，因此适于从血细胞分选纳米颗粒。 根据本发明制备的样品适用于在血液中纳米颗粒的真实分布状态的TEM观察。 在Z方向极微小的空间高度消除了在干燥过程中纳米颗粒聚集和/或Z方向附聚的可能性; 因此，根据本发明制备的样品适用于在血液中纳米颗粒的分散和/或附聚的TEM观察。

公开(公告)号：US20080075928A1

公开(公告)日：2008-03-27

申请号：US11857967

申请日：2007-09-19

Applicant: Gemunu Gunaratne ,  Girish Nathan ,  Donald Kouri ,  Pradeep Sharma ,  Fazle Hussain ,  Feng Shi

Inventor： Gemunu Gunaratne ,  Girish Nathan ,  Donald Kouri ,  Pradeep Sharma ,  Fazle Hussain ,  Feng Shi

IPC: B32B1/00 ,  B05D5/00

CPC classification number: B81C1/00031 ,  B81C2201/0149 ,  B82Y30/00 ,  Y10T428/24628

Abstract: A new approach to fabricating regularly patterned nano-scale structures, by self assembly of the structures is disclosed, where a pattern of nano-lines are deposited on a substrate and nano-structures are grown by self assembly in regions between the lines to form regular or patterned nano-scale structures, which are ideally suited for the construction nano-scale materials, nano-scale electronic devices and other nano-scale objects, apparatuses or devices. The invention also relates to methods of making and using same.

Abstract translation: 公开了通过结构的自组装制造规则图案的纳米尺度结构的新方法，其中纳米线的图案沉积在衬底上并且纳米结构通过自组装在线之间的区域中生长以形成规则 或图案化纳米尺度结构，其理想地适用于构造纳米级材料，纳米级电子器件和其它纳米尺度物体，装置或器件。 本发明还涉及制造和使用它们的方法。