公开(公告)号：US20110223109A1

公开(公告)日：2011-09-15

申请号：US12671622

申请日：2008-07-31

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K49/00

CPC classification number: G01N33/57434 ,  A61K49/0004 ,  G01N2333/71

Abstract: In order to determine the aggressiveness of a prostate tumor, a diagnostic substance is administered to a patient that includes a biomarker provided with a first label that is detectable with a detection device and that specifically binds to a VEGF molecule, and that contains a biomarker that binds specifically to a target molecule that occurs uniformly in the endothelium of blood vessels of healthy tissue and the blood vessels of a prostate tumor, and that is provided with a second label that is detectable with the detection device independently of the first label.

Abstract translation: 为了确定前列腺肿瘤的侵袭性，向患者施用诊断物质，所述患者包括具有可用检测装置检测并且特异性结合VEGF分子的第一标记的生物标志物，并且其含有生物标志物 与在前列腺肿瘤的健康组织和血管的血管的内皮中均匀发生的目标分子特异性结合，并且具有与检测装置独立于第一标记可检测的第二标记。

公开(公告)号：US20090087384A1

公开(公告)日：2009-04-02

申请号：US12203277

申请日：2008-09-03

Applicant: Sueleyman Erguen ,  Jens Fehre ,  Ralf Nanke ,  Bernhard Singer ,  Martin Stetter ,  Derya Tilki

Inventor： Sueleyman Erguen ,  Jens Fehre ,  Ralf Nanke ,  Bernhard Singer ,  Martin Stetter ,  Derya Tilki

IPC: A61K49/22 ,  A61K31/337

CPC classification number: A61K49/223 ,  A61K9/0009 ,  A61K41/0028 ,  A61K47/6843 ,  A61K47/6869 ,  A61K47/6925

Abstract: The invention concerns a medicine for treatment of prostate cancer and a corresponding treatment method. The medicine can be supplied to a prostate tumor through the bloodstream, contains an active component and a binding component as well as ultrasound microbubbles. The binding component includes coupling molecules that specifically bind to a determined target molecule formed in the endothelium of tumor-associated blood vessels and that is typical of the tumor or the tumor stage. The active component contains at least one chemotherapeutic substance. The coupling molecules are bound to the outside of the microbubbles and active substance molecules are likewise bound to the outside of the microbubbles or are enclosed by the microbubbles.

Abstract translation: 本发明涉及用于治疗前列腺癌的药物和相应的治疗方法。 药物可以通过血液供应给前列腺肿瘤，含有活性成分和结合成分以及超声微泡。 结合组分包括与肿瘤相关血管的内皮中形成的确定的靶分子特异性结合并且是肿瘤或肿瘤阶段典型的偶联分子。 活性成分含有至少一种化学物质。 偶联分子结合到微泡的外部，活性物质分子同样地结合到微泡的外部或被微泡封闭。

公开(公告)号：US07449003B2

公开(公告)日：2008-11-11

申请号：US10458095

申请日：2003-06-10

Applicant: Jens Fehre ,  Bernd Granz ,  Christian Meinert ,  Ralf Nanke

Inventor： Jens Fehre ,  Bernd Granz ,  Christian Meinert ,  Ralf Nanke

IPC: A61H1/00

CPC classification number: A61B17/2251

Abstract: A bellows for coupling a source of acoustic waves having an acoustic propagation medium, to a patient, has a geometrical modification in that region wherein the bellows can be seated against the patient for the introduction of acoustic waves into the patient. The geometrical modification in the propagation path of the acoustic waves generated by the source of acoustic waves shapes the acoustic waves in a designated (designed) manner. Additionally or alternatively, the bellows can have a section in the region that is formed of a different material than the rest of the bellows.

Abstract translation: 用于将具有声传播介质的声波源耦合到患者的波纹管在该区域中具有几何修改，其中波纹管可以抵靠患者就座以将声波引入患者体内。 由声波源产生的声波的传播路径中的几何修改以指定（设计）的方式对声波进行整形。 附加地或替代地，波纹管可以具有由与波纹管的其余部分不同的材料形成的区域中的部分。

公开(公告)号：US20070016114A1

公开(公告)日：2007-01-18

申请号：US11478889

申请日：2006-06-30

Applicant: Gerhard Buchholtz ,  Jens Fehre ,  Bernd Granz ,  Martin Hoheisel ,  Werner Kruft ,  Markus Lanski ,  Matthias Mahler ,  Christian Meinert ,  Thomas Mertelmeier ,  Ralf Nanke ,  Manfred Rattner

Inventor： Gerhard Buchholtz ,  Jens Fehre ,  Bernd Granz ,  Martin Hoheisel ,  Werner Kruft ,  Markus Lanski ,  Matthias Mahler ,  Christian Meinert ,  Thomas Mertelmeier ,  Ralf Nanke ,  Manfred Rattner

IPC: A61H1/00

CPC classification number: A61B6/466 ,  A61B6/12 ,  A61B6/4441 ,  A61B17/2255 ,  A61B17/2256 ,  A61B2090/376

Abstract: In a method to disintegrate a calculus in a patient by shockwave lithotripsy, a 3D image data set of the patient is generated in a first step; the shockwave lithotripsy is conducted in a second step; and first step and second step are conducted with an unchanged position of the patient. A lithotripsy system to disintegrate a calculus in a patient has a shockwave system to disintegrate the calculus and a 3D imaging system to generate a 3D image data set of the patient without movement of the patient.

Abstract translation: 在通过冲击波碎石术分解患者的结石的方法中，在第一步骤中产生患者的3D图像数据集; 冲击波碎石进行第二步; 并且以患者的不变位置进行第一步骤和第二步骤。 用于分解患者中的结石的碎石系统具有冲击波系统以分解微积分，并且具有3D成像系统以在患者的移动的情况下生成患者的3D图像数据集。

公开(公告)号：US20060012775A1

公开(公告)日：2006-01-19

申请号：US10535804

申请日：2003-10-07

Applicant: Bernd Granz ,  Ralf Nanke

Inventor： Bernd Granz ,  Ralf Nanke

IPC: G01D5/26

CPC classification number: A61B17/22029 ,  A61B17/22 ,  G01H9/00

Abstract: An optical hydrophone for measurement of the acoustic pressure distribution in a fluid medium has a light source that illuminates an area of a boundary region between an optically transparent body and the fluid medium. A light receiver measures the intensity of the light reflected from the illuminated area as a measurement of acoustic pressure, due to changes in the index of refraction of the fluid medium that are caused by the acoustic pressure. The illuminated area is smaller than the boundary surface formed between the optically transparent body and the fluid medium, thereby giving the hydrophone a longer service light and a high spatial resolution capacity.

Abstract translation: 用于测量流体介质中的声压分布的光学水听器具有照亮光学透明体和流体介质之间的边界区域的区域的光源。 由于由声压引起的流体介质的折射率的变化，光接收器测量从照明区域反射的光的强度作为声压的测量值。 照明区域小于在光学透明体和流体介质之间形成的边界面，从而使水听器具有更长的使用光和高的空间分辨能力。

公开(公告)号：US20140016741A1

公开(公告)日：2014-01-16

申请号：US13939393

申请日：2013-07-11

Applicant: Thomas Mertelmeier ,  Ralf Nanke

Inventor： Thomas Mertelmeier ,  Ralf Nanke

IPC: A61B6/00

CPC classification number: A61B6/502 ,  A61B6/025 ,  A61B6/0414

Abstract: In this device and the associated method, a connection unit that can be attached to an arm bearing an x-ray source and an x-ray receiver is fashioned such that said connection unit compensates for a pivot movement of the arm so that a compression unit arranged at the connection unit remains stationary during a pivot movement.

Abstract translation: 在该装置和相关联的方法中，可以将连接单元连接到具有x射线源和X射线接收器的臂上，使得所述连接单元补偿臂的枢转运动，使得压缩单元 布置在连接单元处的枢转运动期间保持静止。

公开(公告)号：US20130096438A1

公开(公告)日：2013-04-18

申请号：US13805205

申请日：2011-05-11

Applicant: Jens Fehre ,  Ralf Nanke

Inventor： Jens Fehre ,  Ralf Nanke

IPC: A61B1/04

CPC classification number: A61B1/043 ,  A61B1/041 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4205 ,  G01N21/6408 ,  G01N21/6486 ,  G06K9/00147 ,  G06K2209/053

Abstract: In a method and apparatus for detecting tumorous cell tissue in a gastrointestinal tract, electromagnetic radiation is emitted in a locally defined manner from an endoscope onto cell tissue and, after deactivation of the radiation, the decay of the inherent fluorescence intensity of the irradiated cell tissue, excited by the electromagnetic radiation, is detected, with temporal and spectral resolution and with a known scanning rate for at least one wavelength. From the intensity measurement values obtained in this manner, the difference autocorrelation function of the intensity decay is determined, from which a fractal dimension for the irradiated cell tissue is determined. The value of the fractal dimension is used to classify the irradiated cell tissue as to a degree to which the cell tissue is tumorous.

Abstract translation: 在用于检测胃肠道中的肿瘤细胞组织的方法和装置中，电磁辐射以局部限定的方式从内窥镜发射到细胞组织上，并且在辐射失活之后辐射细胞组织的固有荧光强度的衰减 被电磁辐射激发，被检测到，具有时间和光谱分辨率，并具有用于至少一个波长的已知扫描速率。 根据以这种方式获得的强度测量值，确定强度衰减的差分自相关函数，确定照射的细胞组织的分形维数。 分形维数的值用于将照射的细胞组织分类为细胞组织肿瘤程度。

公开(公告)号：US08386012B2

公开(公告)日：2013-02-26

申请号：US12671643

申请日：2008-07-31

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61B5/05

CPC classification number: G01R33/1269 ,  A61B5/06 ,  A61B5/4381 ,  A61K49/00 ,  A61K49/0004

Abstract: In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one ferromagnetic particle, the biomarker binding specifically to a target molecule that is formed by specific pathological prostrate tissue. The diagnostic substance is administered to the blood stream of a patient. A magnetometer is used to detect enrichment of the ferromagnetic particle in the prostrate, as an indicator of a level of the specific pathological prostrate tissue.

Abstract translation: 在筛选试验方法以及实施筛选试验方法的装置中，提供了含有至少一种与至少一个铁磁性粒子连接的生物标志物的诊断物质，特异性结合由特异性病理性前列腺素形成的靶分子的生物标志物 组织。 将诊断物质施用于患者的血液流。 磁力计用于检测前列腺中铁磁颗粒的富集，作为特定病理性pro层组织水平的指标。

公开(公告)号：US07942575B2

公开(公告)日：2011-05-17

申请号：US11943786

申请日：2007-11-21

Applicant: Jens Fehre ,  Ralf Nanke ,  Monika Schwarz

Inventor： Jens Fehre ,  Ralf Nanke ,  Monika Schwarz

IPC: H05G1/02

CPC classification number: A61B6/4429 ,  A61B6/587

Abstract: A urological x-ray workstation has an x-ray source and an x-ray receiver that are respectively supported on device retainers of a device carrier located at the longitudinal side of a patient positioning table such that they can be positioned opposite one another and independently of one another in various positions on an orbit proceeding around a common center in a working plane oriented perpendicular to the longitudinal axis.

Abstract translation: 泌尿x射线工作站具有分别支撑在位于患者定位台的纵向侧的装置载体的装置保持器上的x射线源和x射线接收器，使得它们可以彼此相对定位并且独立地定位 在垂直于纵向轴线定向的工作平面中的公共中心周围的轨道上的各种位置。

公开(公告)号：US20100286517A1

公开(公告)日：2010-11-11

申请号：US12774798

申请日：2010-05-06

Applicant: Ali Kamen ,  Wolfgang Wein ,  Parmeshwar Khurd ,  Mamadou Diallo ,  Ralf Nanke ,  Jens Fehre ,  Berthold Kiefer ,  Martin Requardt ,  Clifford Weiss

Inventor： Ali Kamen ,  Wolfgang Wein ,  Parmeshwar Khurd ,  Mamadou Diallo ,  Ralf Nanke ,  Jens Fehre ,  Berthold Kiefer ,  Martin Requardt ,  Clifford Weiss

IPC: A61B8/14 ,  A61B8/00

CPC classification number: A61B10/0241 ,  A61B8/4254 ,  A61B34/20 ,  A61B2017/00274 ,  A61B2017/00694 ,  A61B2017/3413 ,  A61B2018/00547 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/367 ,  A61B2090/374 ,  A61B2090/378

Abstract: In a method for image guided prostate cancer needle biopsy, a first registration is performed to match a first image of a prostate to a second image of the prostate. Third images of the prostate are acquired and compounded into a three-dimensional (3D) image. The prostate in the compounded 3D image is segmented to show its border. A second registration and then a third registration different from the second registration is performed on distance maps generated from the prostate borders of the first image and the compounded 3D image, wherein the first and second registrations are based on a biomechanical property of the prostate. A region of interest in the first image is mapped to the compounded 3D image or a fourth image of the prostate acquired with the second modality.

Abstract translation: 在用于图像引导的前列腺癌针活检的方法中，首先进行配准以将前列腺的第一图像与前列腺的第二图像相匹配。 获取前列腺的第三图像并将其复合成三维（3D）图像。 复合3D图像中的前列腺被分割以显示其边界。 在从第一图像和复合3D图像的前列腺边界产生的距离图上执行与第二登记不同的第二登记，然后第三登记，其中第一和第二登记基于前列腺的生物力学性质。 将第一图像中的感兴趣区域映射到复合3D图像或用第二模态获取的前列腺的第四图像。