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11.发明授权Pyrazolo quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑喹啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US08541429B2
公开(公告)日：2013-09-24
申请号：US12262933
申请日：2008-10-31
Applicant: Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
Inventor： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC: A01N43/54 , A61K31/505
CPC classification number: C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
Abstract translation: 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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12.发明申请Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其用作激酶抑制剂公开(公告)号：US20090124605A1
公开(公告)日：2009-05-14
申请号：US12262933
申请日：2008-10-31
Applicant: Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
Inventor： Gabriella Traquandi , Maria Gabriella Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC: A61K31/551 , A61K31/519 , C12N9/99 , C07D487/04 , A61K31/496 , A61P25/28 , A61P17/06 , A61P37/06 , A61P37/00 , A61P35/00 , C07D401/14 , C07D413/14 , A61K31/5377
CPC classification number: C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
Abstract translation: 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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13.发明申请Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors 有权吡唑并喹唑啉衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US20070185143A1
公开(公告)日：2007-08-09
申请号：US10557565
申请日：2004-04-27
Applicant: Gabriella Traquandi , Maria Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
Inventor： Gabriella Traquandi , Maria Brasca , Roberto D'Alessio , Paolo Polucci , Fulvia Roletto , Anna Vulpetti , Paolo Pevarello , Achille Panzeri , Francesca Quartieri , Ron Ferguson , Paola Vianello , Daniele Fancelli
IPC: A61K31/505
CPC classification number: C07D487/14 , A61K31/519 , A61K31/5377 , A61K31/551 , C07D231/56 , C07D239/72 , C07D401/10 , C07D403/14 , C07D413/14 , C07D487/04
Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention maybe useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer”.
Abstract translation: 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与抑制性蛋白激酶活性相关的疾病如癌症“。
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Patent Agency Ranking
公开(公告)号：US4757061A
公开(公告)日：1988-07-12
申请号：US828637
申请日：1986-02-10
Applicant: Franco Faustini , Roberto D'Alessio , Vittoria Villa , Enrico di Salle , Paolo Lombardi
Inventor： Franco Faustini , Roberto D'Alessio , Vittoria Villa , Enrico di Salle , Paolo Lombardi
IPC: A61K31/565 , A61K31/58 , A61P3/00 , A61P35/00 , C07J1/00 , C07J17/00 , C07J31/00 , C07J33/00 , C07J41/00 , C07J43/00 , A61K31/56
CPC classification number: C07J41/0005 , C07J41/0027
Abstract: The invention discloses 4-substituted androstendione derivatives of the following formula (I) ##STR1## wherein R is amino or substituted amino or azido,one of R.sub.1 and R.sub.2 is hydrogen and the other is hydrogen, alkyl, alkenyl or alkynyl, and(x) and (y) are each, independently, a single bond or a double bond.The compounds of formula (I) are useful aromatase inhibitors.
Abstract translation: 本发明公开了下式（I）的4-取代的雄烯二酮衍生物：其中R是氨基或取代的氨基或叠氮基，R1和R2之一是氢，另一个是氢，烷基，烯基或炔基， 和（x）和（y）各自独立地为单键或双键。 式（I）化合物是有用的芳香酶抑制剂。
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15.发明申请TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权三聚吡咯衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US20130296305A1
公开(公告)日：2013-11-07
申请号：US13980168
申请日：2012-01-19
Applicant: Marina Caldarelli , Mauro Angiolini , Italo Beria , Maria Gabriella Brasca , Francesco Casuscelli , Roberto D'Alessio , Andrea Lombardi Borgia
Inventor： Marina Caldarelli , Mauro Angiolini , Italo Beria , Maria Gabriella Brasca , Francesco Casuscelli , Roberto D'Alessio , Andrea Lombardi Borgia
IPC: C07D487/04 , A61K31/55 , A61K45/06 , A61K31/519
CPC classification number: C07D487/04 , A61K31/519 , A61K31/55 , A61K45/06 , C07C67/00 , C07D207/34 , C07D209/42 , C07D401/04 , C12N9/99
Abstract: The present invention relates to tricyclic pyrrolo derivatives of Formula (I), which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
Abstract translation: 本发明涉及式（I）的三环吡咯衍生物，其调节蛋白激酶的活性，因此可用于治疗由失调的蛋白激酶活性引起的疾病。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及使用这些化合物治疗疾病的方法或含有它们的药物组合物的方法。
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公开(公告)号：US07279575B2
公开(公告)日：2007-10-09
申请号：US10912319
申请日：2004-08-05
Applicant: Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
Inventor： Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
IPC: C07D239/02 , A01N43/54 , A61K31/505
CPC classification number: C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00
Abstract: Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
Abstract translation: 公开了式（I）的嘧啶基吡咯衍生物及其药学上可接受的盐，如本说明书中定义的制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US20050043323A1
公开(公告)日：2005-02-24
申请号：US10912319
申请日：2004-08-05
Applicant: Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
Inventor： Ermes Vanotti , Roberto D'Alessio , Marcellino Tibolla , Mario Varasi , Alessia Montagnoli , Corrado Santocanale , Paolo Orsini , Antonio Pillan
IPC: A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00
Abstract: Pyrimidylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
Abstract translation: 公开了本说明书中定义的式（I）的嘧啶基吡咯衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US06369096B1
公开(公告)日：2002-04-09
申请号：US09402455
申请日：1999-10-07
Applicant: Roberto D'Alessio , Ermes Vanotti , Alberto Bargiotti , Marcellino Tibolla , Mario Ferrari , Anna Maria Isetta , Francesco Colotta
Inventor： Roberto D'Alessio , Ermes Vanotti , Alberto Bargiotti , Marcellino Tibolla , Mario Ferrari , Anna Maria Isetta , Francesco Colotta
IPC: A61K314025
CPC classification number: C07D207/44
Abstract: A compound, having utility as an immunomodulating agent, which is a prodigiosine of formula (I): wherein R1 is hydrogen or C1-C5 alkyl; and R2 is a C1-C5 alkyl; or a pharmaceutically acceptable salt thereof.
Abstract translation: 具有作为免疫调节剂的作用的化合物，其是式（I）的产物：其中R 1是氢或C 1 -C 5烷基; 并且R 2是C 1 -C 5烷基;或其药学上可接受的盐。
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