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公开(公告)号：US20220105114A1
公开(公告)日：2022-04-07
申请号：US17499648
申请日：2021-10-12
Applicant: UNIVERSITY OF CONNECTICUT , STOWERS INSTITUTE FOR MEDICAL RESEARCH , UNIVERSITY OF KANSAS
Inventor： Rajeswari KASI , Linheng Ll , Xiuling LU , John M. PERRY , Gurusingham Sitta SITTAMPALAM , Anuradha ROY , Xi C. HE
IPC: A61K31/704 , A61K9/51 , A61K31/513 , A61K31/136 , A61K31/4745 , A61K45/06 , A61K31/573 , A61K9/00 , A61K31/18 , A61K31/475 , A61K31/519 , A61K31/7076 , A61K31/708 , A61K31/337 , A61K33/242 , A61K33/243 , A61P35/02
Abstract: The disclosure provides methods of treating cancer by selectively inhibiting p-S552-β-catenin, p-T217-β-catenin, T332-β-catenin, and/or p-S675-β-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.
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公开(公告)号：US20200370044A1
公开(公告)日：2020-11-26
申请号：US16754714
申请日：2018-10-09
Inventor： Zhenrui Li , Pengxu Qian , Linheng Li , Chuan He
IPC: C12N15/113 , C12N5/0789 , A61K35/28
Abstract: The present invention relates to methods for expanding a stem cell population, as well as other cell populations. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell and/or other cell population, particularly a hematopoietic stem cell population.
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公开(公告)号：US10787643B2
公开(公告)日：2020-09-29
申请号：US14634540
申请日：2015-02-27
Applicant: Stowers Institute for Medical Research
Inventor： John M. Perry , Linheng Li , Justin C. Grindley
IPC: C12N5/00 , C12N5/02 , C12N5/18 , A61K35/28 , C12N5/0789
Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
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公开(公告)号：US20180207184A1
公开(公告)日：2018-07-26
申请号：US15745875
申请日：2016-07-28
Applicant: UNIVERSITY OF CONNECTICUT , STOWERS INSTITUTE FOR MEDICAL RESEARCH , UNIVERSITY OF KANSAS
Inventor： Rajeswari KASI , Linheng Ll , Xiuling LU , John M. PERRY , Gurusingham Sitta SITTAMPALAM , Anuradha ROY , Xi C. HE
IPC: A61K31/704 , A61K9/51 , A61P35/02
CPC classification number: A61K31/704 , A61K9/0009 , A61K9/0019 , A61K9/5138 , A61K9/5146 , A61K31/136 , A61K31/18 , A61K31/337 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/573 , A61K31/7076 , A61K31/708 , A61K33/24 , A61K45/06 , A61P35/02 , A61K2300/00
Abstract: The disclosure provides methods of treating cancer by selectively inhibiting p-S552-β-catenin, p-T217-β-catenin, p-T332-β-catenin, and/or p-S675-β-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.
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公开(公告)号：US09102750B2
公开(公告)日：2015-08-11
申请号：US14171932
申请日：2014-02-04
Applicant: Stowers Institute for Medical Research
Inventor： Arcady Mushegian , Congrong Yu , Joel Schwartz , Limei Ma
IPC: C07K14/435
CPC classification number: C07K14/43504
Abstract: The present invention provides compositions, combinations, methods, sequences and kits for use of novel fluorescent proteins derived from the genus Branchiostoma. Specifically, polynucleotide and polypeptide sequences encoding fluorescent proteins isolated from Branchiostoma floridae, including harmonized sequences, which permit enhanced expression of the encoded polypeptides in mammalian cells in vivo are provided.
Abstract translation: 本发明提供了用于衍生自分枝杆菌属的新型荧光蛋白的组合物，组合，方法，序列和试剂盒。 具体地说，提供了编码从分枝杆菌分离的荧光蛋白的多核苷酸和多肽序列，包括协调序列，其允许体内哺乳动物细胞中编码的多肽的表达增强。
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Patent Agency Ranking
公开(公告)号：US20140255359A1
公开(公告)日：2014-09-11
申请号：US14352410
申请日：2012-10-17
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： John M. Perry , Linheng Li , Aparna Venkatraman , Xi He
IPC: C12N5/0789 , A61K35/28
CPC classification number: C12N5/0647 , A61K35/28 , C12N2501/06 , C12N2501/415
Abstract: Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed.
Abstract translation: 公开了在DNA甲基转移酶调节剂和Wnt途径调节剂存在下扩增干细胞群体，特别是造血干细胞群体的方法和试剂盒。
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公开(公告)号：US12084666B2
公开(公告)日：2024-09-10
申请号：US16608146
申请日：2018-04-27
Inventor： Sarah E. Zanders , Nicole Nuckolls , Maria Angelical Bravo Nunez , Harmit Singh Malik
CPC classification number: C12N15/815 , C07K14/39 , C12N1/00 , C12N2800/00 , C12N2840/007
Abstract: The present disclosure provides, inter alia, meiotic drive genes derived from chromosome 3 of the fission yeasts Schizosaccharomyces kambucha and S. pombe and orthologs thereof. In certain embodiments, compositions, methods, and kits are provided for biasing organisms to express such genes and, optionally, to co-express one or more genes of interest in such organisms.
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18.发明公开公开(公告)号：US20230360370A1
公开(公告)日：2023-11-09
申请号：US18343557
申请日：2023-06-28
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Congrong Yu , Rishabh Raj
CPC classification number: G06V10/7715 , G06V10/82
Abstract: This disclosure relates to improved systems, methods, and techniques for constructing and employing neural network architectures to solve computer vision and other problems. The neural network architectures can have two or three layers with all nodes in the first layer connected to all nodes in the second layer. The nodes in the second layer can be connected to each other. The weights or values of the various connections between these nodes in the first two layers can also be updated between the processing of inputs to the neural network architectures. These neural network architectures do not require extensive training and can learn continuously. Other embodiments are disclosed herein as well.
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19.发明公开公开(公告)号：US20230360367A1
公开(公告)日：2023-11-09
申请号：US18343577
申请日：2023-06-28
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Congrong Yu , Rishabh Raj
IPC: G06V10/764 , G06V10/82
CPC classification number: G06V10/764 , G06V10/82
Abstract: This disclosure relates to improved systems, methods, and techniques for constructing and employing neural network architectures to solve computer vision and other problems. The neural network architectures can have two or three layers with all nodes in the first layer connected to all nodes in the second layer. The nodes in the second layer can be connected to each other. The weights or values of the various connections between these nodes in the first two layers can also be updated between the processing of inputs to the neural network architectures. These neural network architectures do not require extensive training and can learn continuously. Other embodiments are disclosed herein as well.
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公开(公告)号：US11173173B2
公开(公告)日：2021-11-16
申请号：US15745875
申请日：2016-07-28
Applicant: UNIVERSITY OF CONNECTICUT , STOWERS INSTITUTE FOR MEDICAL RESEARCH , UNIVERSITY OF KANSAS
Inventor： Rajeswari Kasi , Linheng Li , Xiuling Lu , John M. Perry , Gurusingham Sitta Sittampalam , Anuradha Roy , Xi C. He
IPC: A61K9/51 , A61K31/704 , A61K31/513 , A61K31/136 , A61K31/4745 , A61K45/06 , A61K31/573 , A61K9/00 , A61K31/18 , A61K31/475 , A61K31/519 , A61K31/7076 , A61K31/708 , A61K31/337 , A61K33/242 , A61K33/243 , A61P35/02
Abstract: The disclosure provides methods of treating cancer by selectively inhibiting p-S552-β-catenin, p-T217-β-catenin, p-T332-β-catenin, and/or p-S675-β-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.
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