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124 条记录 (耗时 0.032 秒)

    Oxazoloisoquinoline derivatives as thrombin receptor antagonists
    12.
    发明授权
    Oxazoloisoquinoline derivatives as thrombin receptor antagonists 有权
    恶唑啉异喹啉衍生物作为凝血酶受体拮抗剂

    公开(公告)号：US07888369B2

    公开(公告)日：2011-02-15

    申请号：US11642170

    申请日：2006-12-20

    申请人： Samuel Chackalamannil ,  Yuguang Wang

    发明人： Samuel Chackalamannil ,  Yuguang Wang

    IPC分类号： C07D491/14 ,  A61K31/4355 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P9/06 ,  A61P9/00 ,  A61P9/02

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： This application provides for oxazolisoquinoline derivatives of the formula or a pharmaceutically acceptable salt of said compound wherein: B is —CH═CH—; M is —C(R1)(R2)—; and the remaining substituents are as defined in the specification as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. This application also provides for combination therapy with the compounds of Ib or pharmaceutically acceptable salts thereof with other cardiovascular agents.

    摘要翻译： 本申请提供了下式的恶唑啉喹啉衍生物或所述化合物的药学上可接受的盐，其中：B是-CH = CH-; M是-C（R 1）（R 2） - ; 并且其余的取代基如本说明书中所定义，以及含有它们的药物组合物以及通过施用所述化合物治疗与血栓形成，动脉粥样硬化，再狭窄，高血压，心绞痛，心律失常，心力衰竭和癌症相关的疾病的方法。 本申请还提供了将Ib化合物或其药学上可接受的盐与其它心血管药物组合治疗。

    Muscarinic antagonists
    14.
    发明授权
    Muscarinic antagonists 失效
    毒蕈碱拮抗剂

    公开(公告)号：US06890936B2

    公开(公告)日：2005-05-10

    申请号：US10425376

    申请日：2003-04-28

    申请人： Craig D. Boyle ,  William J. Greenlee ,  Samuel Chackalamannil

    发明人： Craig D. Boyle ,  William J. Greenlee ,  Samuel Chackalamannil

    IPC分类号： A61P25/00 ,  C07D211/96 ,  C07D221/20 ,  C07D211/06 ,  A61K31/555

    CPC分类号： C07D221/20 ,  C07D211/96

    摘要： The invention described herein are compounds in accordance with formula I: wherein R1, R2, R3, R4, R5, R6, R2, R8, R9, n, X, and Z are as defined herein, pharmaceutical compositions containing at least one compound of formula I, methods of preparation thereof, and methods of treating disorders with at least one compound of formula I or at least one compound of formula I in association with at least one acetylcholinesterase inhibitor.

    摘要翻译： 本文描述的本发明是根据式I的化合物：其中R 1，R 2，R 3，R 4， R S，R 5，R 6，R 2，R 8，R 9， SUP，n，X和Z如本文所定义，药物组合物含有至少一种式I化合物，其制备方法，以及使用至少一种式I化合物或至少一种式 I与至少一种乙酰胆碱酯酶抑制剂有关。

    Preparation of azetidinones via novel protected intermediates
    17.
    发明授权
    Preparation of azetidinones via novel protected intermediates 失效
    通过新型受保护的中间体制备氮杂环丁酮

    公开(公告)号：US5008404A

    公开(公告)日：1991-04-16

    申请号：US496468

    申请日：1990-03-20

    申请人： Samuel Chackalamannil

    发明人： Samuel Chackalamannil

    IPC分类号： A47F5/02 ,  C07D303/12 ,  C07D205/08

    CPC分类号： A47F5/02

    摘要： A multistep process is disclosed for preparing azetidinone intermediates used in the making penems and carbapenems wherein intermediates containing ##STR1## R' is independently hydrogen or 1, 2 or 3 of lower alkyl or lower alkoxy, preferably hydrogen, wherein R" is methyl, ethyl, a phenyl or alkyl, preferably ethyl, as a readily removable nitrogen protecting group are made.

    摘要翻译： 公开了一种用于制备用于制备青蒿素和碳青霉烯类似物的氮杂环丁酮中间体的多步法，其中含有R 1的中间体独立地为氢或低级烷基或低级烷氧基，优选氢，或其中R“为甲基的1,2或3， 乙基，苯基或烷基，优选乙基，作为容易除去的氮保护基。