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    Ten-M3 polypeptides and polynucleotides and their methods of use
    13.
    发明申请
    Ten-M3 polypeptides and polynucleotides and their methods of use 审中-公开
    10-M3多肽和多核苷酸及其使用方法

    公开(公告)号：US20050244868A1

    公开(公告)日：2005-11-03

    申请号：US11096051

    申请日：2005-03-30

    申请人： Ramesh Kekuda ,  Timothy MacLachlan ,  Meera Patturajan ,  Luca Rastelli ,  Seth Ettenberg ,  Corine Vernet

    发明人： Ramesh Kekuda ,  Timothy MacLachlan ,  Meera Patturajan ,  Luca Rastelli ,  Seth Ettenberg ,  Corine Vernet

    IPC分类号： C07H21/04 ,  C07K14/705 ,  C07K14/82 ,  C07K16/30 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： C07K14/70571

    摘要： Disclosed herein are novel Ten-M3 polynucleotides encoding novel polypeptides and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

    摘要翻译： 本文公开了编码新颖多肽的免疫特异性结合的新的多肽和抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法也包括在内。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

    MOLECULES AND METHODS FOR MODULATING LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 (LRP6)
    15.
    发明申请
    MOLECULES AND METHODS FOR MODULATING LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 (LRP6) 审中-公开
    用于调节低密度脂蛋白受体相关蛋白6（LRP6）的分子和方法

    公开(公告)号：US20100254980A1

    公开(公告)日：2010-10-07

    申请号：US12740134

    申请日：2008-10-31

    申请人： Feng Cong ,  Shamina M. Rangwala ,  Seth Ettenberg ,  Sabine Guth

    发明人： Feng Cong ,  Shamina M. Rangwala ,  Seth Ettenberg ,  Sabine Guth

    IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P3/10 ,  A61P25/28 ,  A61P19/10 ,  A61P3/04 ,  A61P19/02 ,  A61P35/00

    CPC分类号： C07K16/2863 ,  C07K2317/55 ,  C07K2317/75 ,  C07K2317/76

    摘要： The invention discloses LRP6 agonizing or antagonizing binding molecules (e.g., antibodies or a Fab fragments), and their use to facilitate or inhibit Wnt pathway signaling, respectively. Said LRP6 agonizing or antagonizing binding molecules can be used to e.g., diagnose, ameliorate the symptoms of, protect against, and treat Wnt signaling disorders associated with aberrantly low or aberrantly high levels of Wnt pathway signaling, respectively. Non-limiting examples of disorders which can be treated associated with aberrant upregulation of Wnt signaling is cancer (e.g., colon cancer). Non-limiting examples of disorders which can be diagnosed, protected against, and treated include cancers, bone disorders (e.g., osteoporosis and osteoarthritis), diabetes, neurodegenerative diseases such as Alzheimer's disease, and fibrotic disorders.

    摘要翻译： 本发明公开了分别促进或抑制Wnt通路信号传导的LRP6激动或拮抗结合分子（例如，抗体或Fab片段）及其用途。 所述LRP6激动或拮抗结合分子可分别用于例如诊断，改善与异常低或异常高水平的Wnt通路信号传导相关的Wnt信号传导障碍的症状，保护和治疗。 可以与Wnt信号传导异常上调相关的病症的非限制性实例是癌症（例如结肠癌）。 可以诊断，保护和治疗的疾病的非限制性实例包括癌症，骨病（例如骨质疏松症和骨关节炎），糖尿病，神经变性疾病如阿尔茨海默病和纤维化病症。