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公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
申请人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
发明人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060003323A1
公开(公告)日：2006-01-05
申请号：US10453372
申请日：2003-06-03
申请人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
发明人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060063200A1
公开(公告)日：2006-03-23
申请号：US11051724
申请日：2005-02-02
申请人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
发明人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/18
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07141549B2
公开(公告)日：2006-11-28
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060013813A1
公开(公告)日：2006-01-19
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , A61K39/395 , C07K14/705 , C07K16/18
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07034132B2
公开(公告)日：2006-04-25
申请号：US10162335
申请日：2002-06-03
申请人： David W. Anderson , Jason C. Baumgartner , Ferenc L. Boldog , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John R. MacDougall , Uriel M. Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol E. A. Pena , Luca Rastelli , Richard A. Shimkets , David J. Stone , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Bryan D. Zerhusen
发明人： David W. Anderson , Jason C. Baumgartner , Ferenc L. Boldog , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John R. MacDougall , Uriel M. Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol E. A. Pena , Luca Rastelli , Richard A. Shimkets , David J. Stone , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Bryan D. Zerhusen
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050170380A1
公开(公告)日：2005-08-04
申请号：US10971479
申请日：2004-10-21
申请人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
发明人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
CPC分类号： C07K14/47 , A61K38/00 , C07K14/54 , C07K14/705 , C07K14/70571
摘要： The present invention provides novel isolated SECX polynucleotides and the membrane-associated or secreted polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译： 本发明提供新的分离的SECX多核苷酸和由SECX多核苷酸编码的膜相关或分泌的多肽。 还提供免疫特异性结合SECX多肽或SECX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了其中SECX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US20060111561A1
公开(公告)日：2006-05-25
申请号：US11217997
申请日：2005-08-31
申请人： Valerie Gerlach , Elma Fernandes , Richard Shimkets , Meera Patturajan , Vladimir Gusev , Stacie Navara , Velizar Tchernev , David Anderson , Xiaojia Guo , Luca Rastelli , Mei Zhong , Muralidhara Padigaru
发明人： Valerie Gerlach , Elma Fernandes , Richard Shimkets , Meera Patturajan , Vladimir Gusev , Stacie Navara , Velizar Tchernev , David Anderson , Xiaojia Guo , Luca Rastelli , Mei Zhong , Muralidhara Padigaru
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/475 , C07K16/22
摘要： Disclosed are novel proteins and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the proteins and polynucleotides, as well as methods for using same.
摘要翻译： 公开了编码相同的新蛋白质和核酸。 还公开了用于产生蛋白质和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。
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公开(公告)号：US07109000B2
公开(公告)日：2006-09-19
申请号：US10087684
申请日：2002-03-01
申请人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
发明人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050244868A1
公开(公告)日：2005-11-03
申请号：US11096051
申请日：2005-03-30
申请人： Ramesh Kekuda , Timothy MacLachlan , Meera Patturajan , Luca Rastelli , Seth Ettenberg , Corine Vernet
发明人： Ramesh Kekuda , Timothy MacLachlan , Meera Patturajan , Luca Rastelli , Seth Ettenberg , Corine Vernet
IPC分类号： C07H21/04 , C07K14/705 , C07K14/82 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/70571
摘要： Disclosed herein are novel Ten-M3 polynucleotides encoding novel polypeptides and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新颖多肽的免疫特异性结合的新的多肽和抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法也包括在内。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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