公开(公告)号：US20060084054A1

公开(公告)日：2006-04-20

申请号：US10455772

申请日：2003-06-04

申请人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

发明人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K16/40 ,  C07K14/47

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20060003323A1

公开(公告)日：2006-01-05

申请号：US10453372

申请日：2003-06-03

申请人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

发明人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050053930A1

公开(公告)日：2005-03-10

申请号：US10454246

申请日：2003-06-03

申请人： David Anderson ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Shlomit Edinger ,  Andrew Eisen ,  Karen Ellerman ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Vladimir Gusev ,  Weizhen Ji ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Tatiana Ort ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Raymond Taupier ,  Velizar Tchernev ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen ,  Mei Zhong

发明人： David Anderson ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Shlomit Edinger ,  Andrew Eisen ,  Karen Ellerman ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Vladimir Gusev ,  Weizhen Ji ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Tatiana Ort ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Raymond Taupier ,  Velizar Tchernev ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen ,  Mei Zhong

IPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20050260713A1

公开(公告)日：2005-11-24

申请号：US11113424

申请日：2005-04-21

申请人： Esha Gangolli ,  Meera Patturajan ,  Corine Vernet ,  Uriel Malyankar ,  Ramesh Kekuda ,  David Stone ,  David Anderson ,  Richard Shimkets ,  Catherine Burgess ,  Bryan Zerhusen ,  Xiaohong Liu ,  Kimberly Spytek ,  Stacie Casman ,  Ference Boldog ,  Glennda Smithson ,  Li Li ,  Weizhen Ji ,  John MacDougall

发明人： Esha Gangolli ,  Meera Patturajan ,  Corine Vernet ,  Uriel Malyankar ,  Ramesh Kekuda ,  David Stone ,  David Anderson ,  Richard Shimkets ,  Catherine Burgess ,  Bryan Zerhusen ,  Xiaohong Liu ,  Kimberly Spytek ,  Stacie Casman ,  Ference Boldog ,  Glennda Smithson ,  Li Li ,  Weizhen Ji ,  John MacDougall

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C07H21/04 ,  C07K14/485 ,  C07K16/22 ,  C12P21/06

CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N2500/04

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20060014153A1

公开(公告)日：2006-01-19

申请号：US10877346

申请日：2004-06-25

申请人： Valerie Gerlach ,  John MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Muralidhara Padigaru ,  Ramesha Kekuda ,  Kimberly Spytek ,  Martin Leach ,  Richard Shimkets

发明人： Valerie Gerlach ,  John MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Muralidhara Padigaru ,  Ramesha Kekuda ,  Kimberly Spytek ,  Martin Leach ,  Richard Shimkets

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050266431A1

公开(公告)日：2005-12-01

申请号：US11064246

申请日：2005-02-22

申请人： William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Joel Bader ,  Aruna Bansal ,  Carol Pena ,  Richard Shimkets ,  Ramesh Kekuda ,  Bryan Zerhusen ,  Glennda Smithson ,  David Anderson ,  Mei Zhong ,  Charles Miller ,  Corine Vernet ,  Tord Hjalt

发明人： William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Joel Bader ,  Aruna Bansal ,  Carol Pena ,  Richard Shimkets ,  Ramesh Kekuda ,  Bryan Zerhusen ,  Glennda Smithson ,  David Anderson ,  Mei Zhong ,  Charles Miller ,  Corine Vernet ,  Tord Hjalt

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C12N1/21 ,  C12Q1/68 ,  C07H21/04 ,  C07K16/40 ,  C12N9/12 ,  C12N15/09 ,  C12P21/06

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

摘要： Disclosed herein is a nucleic acid sequence that encodes a novel polypeptide. Also disclosed is a polypeptide encoded by the nucleic acid sequence, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human nucleic acid and protein. The invention also provides nucleic acids containing single-nucleotide polymorphisms identified for transcribed human sequences, as well as methods of using the nucleic acids.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由核酸序列编码的多肽和免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及该新型人核酸和蛋白质的病症的治疗，诊断和研究方法。 本发明还提供含有针对转录的人序列鉴定的单核苷酸多态性的核酸，以及使用该核酸的方法。

公开(公告)号：US06875570B2

公开(公告)日：2005-04-05

申请号：US09964956

申请日：2001-09-26

申请人： Valerie L. Gerlach ,  John R. MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William M. Grosse ,  John P. Alsobrook, II ,  Denise M. Lepley ,  Catherine E. Burgess ,  Muralidhara Padigaru ,  Ramesh Kekuda ,  Kimberly A. Spytek ,  Martin D. Leach ,  Richard A. Shimkets

发明人： Valerie L. Gerlach ,  John R. MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William M. Grosse ,  John P. Alsobrook, II ,  Denise M. Lepley ,  Catherine E. Burgess ,  Muralidhara Padigaru ,  Ramesh Kekuda ,  Kimberly A. Spytek ,  Martin D. Leach ,  Richard A. Shimkets

IPC分类号： G01N33/53 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/14 ,  A61P7/02 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/10 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/32 ,  A61P27/02 ,  A61P35/00 ,  A61P37/04 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/574

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US06974684B2

公开(公告)日：2005-12-13

申请号：US10211689

申请日：2002-08-01

申请人： David W. Anderson ,  John P. Alsobrook II ,  Ferenc L. Boldog ,  Catherine E. Burgess ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Linda Gorman ,  Xiaojia Sasha Guo ,  Nikolai Khramtsov ,  Denise M. Lepley ,  John R. MacDougall ,  Carol E. A. Pena ,  John A. Peyman ,  Meera Patturajan ,  Daniel K. Rieger ,  Richard A. Shimkets ,  Glennda Smithson ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Mei Zhong

发明人： David W. Anderson ,  John P. Alsobrook II ,  Ferenc L. Boldog ,  Catherine E. Burgess ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Linda Gorman ,  Xiaojia Sasha Guo ,  Nikolai Khramtsov ,  Denise M. Lepley ,  John R. MacDougall ,  Carol E. A. Pena ,  John A. Peyman ,  Meera Patturajan ,  Daniel K. Rieger ,  Richard A. Shimkets ,  Glennda Smithson ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Mei Zhong

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/02

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705

摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050014687A1

公开(公告)日：2005-01-20

申请号：US10391939

申请日：2003-03-19

申请人： David Anderson ,  Loic Giot ,  Xiaojia Guo ,  Denise Lepley ,  Mehdi Mesri ,  Chean Ooi ,  Luca Rastelli ,  Daniel Rieger ,  Glennda Smithson ,  Gary Starling ,  Kam-Fai Tse

发明人： David Anderson ,  Loic Giot ,  Xiaojia Guo ,  Denise Lepley ,  Mehdi Mesri ,  Chean Ooi ,  Luca Rastelli ,  Daniel Rieger ,  Glennda Smithson ,  Gary Starling ,  Kam-Fai Tse

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/567 ,  G01N33/68

CPC分类号： C07K14/47 ,  G01N33/6893 ,  G01N2800/042

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050197292A1

公开(公告)日：2005-09-08

申请号：US11047207

申请日：2005-01-31

申请人： Glennda Smithson ,  Mehdi Mesri ,  Gary Starling

发明人： Glennda Smithson ,  Mehdi Mesri ,  Gary Starling

IPC分类号： A61K38/17 ,  C07K14/72

CPC分类号： A61K38/16 ,  Y02A50/463

摘要： The present invention relates to compositions and methods for preventing and/or treating inflammatory and autoimmune diseases. More particularly, the present invention relates to compositions comprising a CG57008 protein, fragment, derivative, variant, homolog, or analog thereof, and their uses in preventing and/or treating T-cell mediated diseases.

摘要翻译： 本发明涉及用于预防和/或治疗炎性和自身免疫性疾病的组合物和方法。 更具体地，本发明涉及包含CG57008蛋白，其片段，衍生物，变体，同源物或类似物的组合物及其在预防和/或治疗T细胞介导的疾病中的用途。