公开(公告)号：US20060084054A1

公开(公告)日：2006-04-20

申请号：US10455772

申请日：2003-06-04

申请人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

发明人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K16/40 ,  C07K14/47

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20050049192A1

公开(公告)日：2005-03-03

申请号：US10635149

申请日：2003-08-06

申请人： Mei Zhong ,  Weizhen Ji ,  Xiaojia Guo ,  Daniel Rieger ,  Muralidhara Padigaru ,  Rachel Malcolm ,  Kimberly Spytek ,  David Anderson ,  Linda Gorman ,  Elina Catterton ,  John MacDougall ,  David Stone ,  Shlomit Edinger

发明人： Mei Zhong ,  Weizhen Ji ,  Xiaojia Guo ,  Daniel Rieger ,  Muralidhara Padigaru ,  Rachel Malcolm ,  Kimberly Spytek ,  David Anderson ,  Linda Gorman ,  Elina Catterton ,  John MacDougall ,  David Stone ,  Shlomit Edinger

IPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/47

CPC分类号： C07H21/04 ,  A61K38/00 ,  G01N33/68 ,  G01N2500/04 ,  G01N2500/10

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20060003323A1

公开(公告)日：2006-01-05

申请号：US10453372

申请日：2003-06-03

申请人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

发明人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050260713A1

公开(公告)日：2005-11-24

申请号：US11113424

申请日：2005-04-21

申请人： Esha Gangolli ,  Meera Patturajan ,  Corine Vernet ,  Uriel Malyankar ,  Ramesh Kekuda ,  David Stone ,  David Anderson ,  Richard Shimkets ,  Catherine Burgess ,  Bryan Zerhusen ,  Xiaohong Liu ,  Kimberly Spytek ,  Stacie Casman ,  Ference Boldog ,  Glennda Smithson ,  Li Li ,  Weizhen Ji ,  John MacDougall

发明人： Esha Gangolli ,  Meera Patturajan ,  Corine Vernet ,  Uriel Malyankar ,  Ramesh Kekuda ,  David Stone ,  David Anderson ,  Richard Shimkets ,  Catherine Burgess ,  Bryan Zerhusen ,  Xiaohong Liu ,  Kimberly Spytek ,  Stacie Casman ,  Ference Boldog ,  Glennda Smithson ,  Li Li ,  Weizhen Ji ,  John MacDougall

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C07H21/04 ,  C07K14/485 ,  C07K16/22 ,  C12P21/06

CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N2500/04

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20050053930A1

公开(公告)日：2005-03-10

申请号：US10454246

申请日：2003-06-03

申请人： David Anderson ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Shlomit Edinger ,  Andrew Eisen ,  Karen Ellerman ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Vladimir Gusev ,  Weizhen Ji ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Tatiana Ort ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Raymond Taupier ,  Velizar Tchernev ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen ,  Mei Zhong

发明人： David Anderson ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Shlomit Edinger ,  Andrew Eisen ,  Karen Ellerman ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Vladimir Gusev ,  Weizhen Ji ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Tatiana Ort ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Raymond Taupier ,  Velizar Tchernev ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen ,  Mei Zhong

IPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US09161255B2

公开(公告)日：2015-10-13

申请号：US14009638

申请日：2012-03-20

申请人： Tao Xue ,  Junchao Du ,  Hui Liu ,  Qingzhe Deng ,  Chuanyi Liu ,  Xuan Li ,  Weizhen Ji ,  Xiaojun Li ,  Wen He ,  Wenjing Chen ,  Jiangkun Guo

发明人： Tao Xue ,  Junchao Du ,  Hui Liu ,  Qingzhe Deng ,  Chuanyi Liu ,  Xuan Li ,  Weizhen Ji ,  Xiaojun Li ,  Wen He ,  Wenjing Chen ,  Jiangkun Guo

IPC分类号： H04W80/04 ,  H04W88/06 ,  H04W88/08 ,  H04W24/10 ,  H04W24/04

CPC分类号： H04W24/10 ,  H04W24/04

摘要： A reporting method for a network state includes: an intermediate node receiving a data packet; the intermediate node marking the data packet according to the current network state; and the intermediate node forwarding the marked data packet. A detecting method for a network state includes: a sink node receiving a data packet; the sink node parsing the data packet to obtain the marking information about the network state; and the sink node determining the network state according to the marking information. A reporting device corresponding to the reporting method, a detecting device corresponding to the detecting method, and a detecting system comprising the reporting device and the detecting method are also provided.

摘要翻译： 一种网络状态报告方法包括：接收数据分组的中间节点; 中间节点根据当前网络状态标记数据包; 并且中间节点转发标记的数据分组。 一种用于网络状态的检测方法包括：接收节点接收数据分组; 汇聚节点解析数据包，获取关于网络状态的标记信息; 并且汇聚节点根据标记信息确定网络状态。 还提供了与报告方法对应的报告装置，与检测方法相对应的检测装置，以及包括报告装置和检测方法的检测系统。

公开(公告)号：US20140022997A1

公开(公告)日：2014-01-23

申请号：US14009638

申请日：2012-03-20

申请人： Tao Xue ,  Junchao Du ,  Hui Liu ,  Qingzhe Deng ,  Chuanyi Liu ,  Xuan Li ,  Weizhen Ji ,  Xiaojun Li ,  Wen He ,  Wenjing Chen ,  Jiangkun Guo

发明人： Tao Xue ,  Junchao Du ,  Hui Liu ,  Qingzhe Deng ,  Chuanyi Liu ,  Xuan Li ,  Weizhen Ji ,  Xiaojun Li ,  Wen He ,  Wenjing Chen ,  Jiangkun Guo

IPC分类号： H04W24/10

CPC分类号： H04W24/10 ,  H04W24/04

摘要： Disclosed are a reporting method, a detecting method, device and system for a network state. The reporting method for a network state includes: an intermediate node receiving a data packet; the intermediate node marking the data packet according to the current network state; and the intermediate node forwarding the marked data packet. The detecting method for a network state includes: a sink node receiving a data packet; the sink node parsing the data packet to obtain the marking information about the network state; and the sink node determining the network state according to the marking information. With the present document, the problem of heavy network burden due to a method of determining the network state with an active inquiry mode is solved, thus prolonging the service life of each node and optimizing the performance of the system.

摘要翻译： 公开了一种用于网络状态的报告方法，检测方法，设备和系统。 网络状态的报告方法包括：接收数据分组的中间节点; 中间节点根据当前网络状态标记数据包; 并且中间节点转发标记的数据分组。 网络状态检测方法包括：接收节点接收数据包; 汇聚节点解析数据包，获取关于网络状态的标记信息; 并且汇聚节点根据标记信息确定网络状态。 利用本文件解决了由于采用主动查询方式确定网络状态的方法造成网络负担沉重的问题，从而延长了每个节点的使用寿命并优化了系统的性能。