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公开(公告)号：US20060003323A1
公开(公告)日：2006-01-05
申请号：US10453372
申请日：2003-06-03
申请人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
发明人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
申请人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
发明人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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3.发明申请公开(公告)号：US20050053930A1
公开(公告)日：2005-03-10
申请号：US10454246
申请日：2003-06-03
申请人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
发明人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060009634A1
公开(公告)日：2006-01-12
申请号：US11019711
申请日：2004-12-21
申请人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
发明人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
IPC分类号： C07H21/04
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050170380A1
公开(公告)日：2005-08-04
申请号：US10971479
申请日：2004-10-21
申请人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
发明人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
CPC分类号： C07K14/47 , A61K38/00 , C07K14/54 , C07K14/705 , C07K14/70571
摘要： The present invention provides novel isolated SECX polynucleotides and the membrane-associated or secreted polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译： 本发明提供新的分离的SECX多核苷酸和由SECX多核苷酸编码的膜相关或分泌的多肽。 还提供免疫特异性结合SECX多肽或SECX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了其中SECX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US20050179170A1
公开(公告)日：2005-08-18
申请号：US11085154
申请日：2005-03-22
CPC分类号： C08J9/122 , B01J3/008 , C08J2201/032 , C08J2203/06 , C08J2203/08 , C08J2327/12 , C08K3/20 , Y02P20/544 , C08L27/12
摘要： Fluoropolymer materials containing tetrafluoroethylene monomers, such as PTFE, are significantly swollen by supercritical carbon dioxide at high temperatures and pressures. The swollen fluoropolymer is processable by molding, extrusion, and other techniques. In addition, the fluoropolymer may be sintered at significantly lower temperatures compared to a nonswollen fluoropolymer material. The melting temperature of fluorinated polymers containing tetrafluoroethylene and triflouroethylene monomers which are swollen with supercritical carbon dioxide is significantly reduced, thereby permitting manufacturing operations such as extruding and molding to be performed at lower temperatures and with reduced risk of decomposition.
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公开(公告)号：US08336557B2
公开(公告)日：2012-12-25
申请号：US12323629
申请日：2008-11-26
申请人： Ashok Kumar , Carolina Marun , Gregory J. Griscik , David R. Golob , Jon Regrut , Suresh Shenoy , William R. Sweeney , Manuel Marquez-Sanchez
发明人： Ashok Kumar , Carolina Marun , Gregory J. Griscik , David R. Golob , Jon Regrut , Suresh Shenoy , William R. Sweeney , Manuel Marquez-Sanchez
IPC分类号： A24B15/18
摘要： A consumable compressed tobacco product adapted to dissolve in an oral cavity. The compressed tobacco product is formed from a composition that includes at least one tobacco component, at least one flavorant, at least one filler-binder, at least one lubricant, at least one desiccant and at least one glidant. The compressed tobacco products are adapted to dissolve and provide tobacco satisfaction. A method of making a dissolvable compressed tobacco product is also provided.
摘要翻译： 适于溶解在口腔中的消耗性压缩烟草制品。 压缩烟草制品由包含至少一种烟草成分，至少一种调味剂，至少一种填料 - 粘合剂，至少一种润滑剂，至少一种干燥剂和至少一种助流剂的组合物形成。 压缩的烟草制品适应于溶解和提供烟草满意度。 还提供了制造可溶解压缩烟草制品的方法。
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8.发明申请公开(公告)号：US20060210559A1
公开(公告)日：2006-09-21
申请号：US11378514
申请日：2006-03-20
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/705 , C07K16/28 , C12N5/06
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
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公开(公告)号：US20060211031A1
公开(公告)日：2006-09-21
申请号：US11398823
申请日：2006-04-06
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US08714163B2
公开(公告)日：2014-05-06
申请号：US13570012
申请日：2012-08-08
申请人： Ashok Kumar , Suresh Shenoy , Carolina Marun , William R. Sweeney , Manuel Marquez-Sanchez , Jon Regrut , Gregory J. Griscik , David R. Golob
发明人： Ashok Kumar , Suresh Shenoy , Carolina Marun , William R. Sweeney , Manuel Marquez-Sanchez , Jon Regrut , Gregory J. Griscik , David R. Golob
IPC分类号： A24B13/00
摘要： A consumable compressed tobacco product adapted to dissolve in an oral cavity. The compressed tobacco product is formed from a composition that includes at least one tobacco component, at least one flavorant, at least one filler-binder, at least one lubricant, at least one desiccant and at least one glidant. The compressed tobacco products are adapted to dissolve and provide tobacco satisfaction. A method of making a dissolvable compressed tobacco product is also provided.
摘要翻译： 适于溶解在口腔中的消耗性压缩烟草制品。 压缩烟草制品由包含至少一种烟草成分，至少一种调味剂，至少一种填料 - 粘合剂，至少一种润滑剂，至少一种干燥剂和至少一种助流剂的组合物形成。 压缩的烟草制品适应于溶解和提供烟草满意度。 还提供了制造可溶解压缩烟草制品的方法。
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