Shape memory devices and methods for reshaping heart anatomy
    11.
    发明授权
    Shape memory devices and methods for reshaping heart anatomy 失效
    形状记忆装置和重塑心脏解剖的方法

    公开(公告)号:US07594887B2

    公开(公告)日:2009-09-29

    申请号:US11876586

    申请日:2007-10-22

    Abstract: Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

    Abstract translation: 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统,方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状,特别是右心室或左心室,以增加心室的收缩性,从而增加了行程体积,从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时,将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置,例如减小心室的宽度。 这种重新定位由元素随时间推移而维持,从而允许心脏扩张的破坏性影响进展缓慢或逆转。

    Adjustable cardiac valve implant with selective dimensional adjustment
    12.
    发明申请
    Adjustable cardiac valve implant with selective dimensional adjustment 有权
    可调心脏瓣膜植入物,具有选择性尺寸调整

    公开(公告)号:US20050288780A1

    公开(公告)日:2005-12-29

    申请号:US11124405

    申请日:2005-05-06

    Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have, a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.

    Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置,例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能,射频能量,光能和磁能。 因此,随着身体结构改变尺寸和/或形状,可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中,装置包括前部,后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置中的第一形状和第二配置的第二形状,并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离,而基本上不减小两个侧部之间的距离。

    Catheter with electrode having hydrogel layer
    13.
    发明授权
    Catheter with electrode having hydrogel layer 有权
    导管与电极具有水凝胶层

    公开(公告)号:US06671561B1

    公开(公告)日:2003-12-30

    申请号:US09561716

    申请日:2000-05-01

    Inventor: Shahram Moaddeb

    CPC classification number: A61N1/06 A61B18/1492 A61B2018/00154

    Abstract: A catheter having an improved electrode that minimizes irritation to the heart tissue and counters the occurrence of foreign body reactions is provided. The catheter comprises an elongated, flexible catheter body having proximal and distal ends and at least one lumen extending therethrough. At least one electrode, such as a tip electrode or ring electrode, is mounted on the distal end of the catheter body, wherein the electrode comprises a base material having an outer surface and a hydrogel layer applied over at least a portion of the outer surface of the base material. Preferably a drug or other therapeutic agent is incorporated into the hydrogel layer.

    Abstract translation: 提供了具有改善的电极的导管,其使对心脏组织的刺激最小化并且反映了异物反应的发生。 导管包括细长的柔性导管主体,其具有近端和远端以及延伸穿过其中的至少一个内腔。 至少一个电极,例如尖端电极或环形电极,安装在导管主体的远端上,其中电极包括基材,其具有外表面和水凝胶层,该水凝胶层涂覆在外表面的至少一部分上 的基材。 优选地,将药物或其它治疗剂并入到所述水凝胶层中。

    Catheter with enhanced ablation electrode
    14.
    发明授权
    Catheter with enhanced ablation electrode 失效
    导管与增强消融电极

    公开(公告)号:US06475214B1

    公开(公告)日:2002-11-05

    申请号:US09561717

    申请日:2000-05-01

    Inventor: Shahram Moaddeb

    Abstract: An ablation catheter comprises an elongated, flexible catheter body having proximal and distal ends and at least one lumen extending therethrough. A tip electrode having a length of at least about 3 mm is mounted on the distal end of the catheter body. The tip electrode comprises a base material having an outer surface and a porous layer applied over at least a portion of the outer surface of the base material, the porous layer comprising metal nitride, metal oxide, metal carbide, metal carbonitride, carbon, carboxy nitride, or a combination thereof.

    Abstract translation: 消融导管包括细长的柔性导管主体,其具有近端和远端以及延伸穿过其中的至少一个内腔。 具有至少约3mm长度的尖端电极安装在导管主体的远端上。 尖端电极包括具有外表面和多孔层的基材,该多孔层涂覆在基材外表面的至少一部分上,多孔层包括金属氮化物,金属氧化物,金属碳化物,金属碳氮化物,碳, ,或其组合。

    Lead assembly with masked microdisk tip electrode and monolithic controlled release device
    15.
    发明授权
    Lead assembly with masked microdisk tip electrode and monolithic controlled release device 失效
    导线组件,带有掩模微型电极尖端电极和单片控制释放装置

    公开(公告)号:US06405091B1

    公开(公告)日:2002-06-11

    申请号:US09359327

    申请日:1999-07-20

    CPC classification number: A61N1/0565 A61N1/057

    Abstract: A passive fixation, body implantable lead assembly has a cylindrical tip electrode whose outer side surface is covered with a thin dielectric insulating layer so as to mask an active, disk-shaped electrode surface at the distal extremity of the tip electrode. The active electrode surface preferably has an area less than about 1 mm2. An MCRD, in the form of a collar, may be carried by a proximal portion of the tip electrode. Supplementing a set of main tines projecting from the distal end portion of an insulating sheath housing the lead assembly is a set of nubby auxiliary tines extending from the sheath immediately adjacent the distal extremity thereof.

    Abstract translation: 被动固定体植入式导线组件具有圆柱形末端电极,其外侧表面被薄的电介质绝缘层覆盖,以便掩盖尖端电极的远端处的活性盘形电极表面。 活性电极表面优选具有小于约1mm 2的面积。 可以由尖端电极的近端部分承载环形形式的MCRD。 补充从套管导线组件的绝缘护套的远端部分突出的一组主尖齿是一组从紧靠其远端的护套延伸的辅助辅助齿。

    Method for making a body implantable sensor
    16.
    发明授权
    Method for making a body implantable sensor 失效
    制造人体植入式传感器的方法

    公开(公告)号:US5490323A

    公开(公告)日:1996-02-13

    申请号:US380764

    申请日:1995-01-30

    CPC classification number: A61N1/056 A61N1/36557 A61N1/3702 Y10T29/49117

    Abstract: The present invention includes a body implantable lead having a multipolar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having sealing rings, either glass frit or metal, are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the sealing material until they re-flow between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then circumferentially welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.

    Abstract translation: 本发明包括具有多极近端连接器的主体可植入引线,至少一个耦合到至少一个刺激电极的第一导体,用于感测身体的至少一个生理参数的传感器,以及耦合到该主体的第二和第三导体 传感器。 传感器密封在D形外壳中。 传感器组件安装在有利地放置在D形壳体的内部平坦部分上的微电子衬底上。 用密封环(玻璃料或金属)的端盖用于密封外壳的端部。 通过加热密封材料直到它们在端盖和壳体之间再流动,容易实现气密密封。 有利地,传感器端子的尺寸设计成紧密地配合在端盖的窄孔内,然后圆形焊接封闭。 D形传感器放置在具有至少两个流明的载体上。 至少第一和第二导体穿过腔以便与刺激电极和传感器的远端连接。 有利地,D形壳体将需要被密封的面积减少一半以上,从而减小了导线的总直径。 有利地,耦合到传感器的导体独立于刺激导体起作用,从而防止对起搏器的基本操作的干扰。

    Implantable stimulation lead having an advanceable therapeutic drug
delivery system
    17.
    发明授权
    Implantable stimulation lead having an advanceable therapeutic drug delivery system 失效
    植入式刺激引线具有可推进的治疗药物递送系统

    公开(公告)号:US5447533A

    公开(公告)日:1995-09-05

    申请号:US132545

    申请日:1993-10-06

    CPC classification number: A61N1/056 A61N1/057 A61N1/0575

    Abstract: A pacing lead having a stylet introduced anti-inflammatory drug delivery element advanceable from the distal tip electrode. The element is preferably formed as a moldable biocompatible composite material. The element has a biocompatible matrix material which may be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion to the point of either passive or active fixation. The drug delivery element may be rigid and serve to center the active fixation element, preferably a helix, for active fixation of the lead in the myocardium.

    Abstract translation: 具有探针的起搏引线引入从远端末端电极可推进的抗炎药物递送元件。 该元件优选形成为可模制的生物相容性复合材料。 该元件具有生物相容的基质材料,其可与药物和治疗剂组合以通过共溶或扩散至被动或主动固定点来递送药物和试剂。 药物递送元件可以是刚性的,并且用于使活动固定元件(优选螺旋)居中以用于主动固定心肌中的铅。

    DYNAMICALLY ADJUSTABLE SUTURE AND CHORDAE TENDINAE
    19.
    发明申请
    DYNAMICALLY ADJUSTABLE SUTURE AND CHORDAE TENDINAE 审中-公开
    动态可调节和乔治腱

    公开(公告)号:US20080228272A1

    公开(公告)日:2008-09-18

    申请号:US11950407

    申请日:2007-12-04

    CPC classification number: A61F2/2457

    Abstract: Embodiments of a dynamically adjustable artificial chordae tendinae implant are described. In some embodiments the implant includes a body portion, including an adjustable portion. In some embodiments, the implant includes a plurality of adjustable portions. In some embodiments the adjustable element can include a shape memory material. The adjustable portion can be configured to transform from a first conformation to a second conformation in response to an activation energy. In some embodiments, the activation energy can be one of electromagnetic energy, acoustic energy, light energy, thermal energy, electrical energy, mechanical energy, or a combination of energies. The implant couples a heart valve leaflet to a papillary muscle. Activation of the shape memory material regulates tension between the muscle and valve leaflet improving coaptation of heart valve leaflets, and reducing or eliminating regurgitation.

    Abstract translation: 描述了动态调节的人造腱索植入物的实施例。 在一些实施例中,植入物包括主体部分,其包括可调部分。 在一些实施例中,植入物包括多个可调部分。 在一些实施例中,可调元件可以包括形状记忆材料。 可调节部分可以被配置为响应于活化能量从第一构象转变成第二构象。 在一些实施例中,激活能可以是电磁能,声能,光能,热能,电能,机械能或能量的组合中的一种。 植入物将心脏瓣膜小叶结合到乳头肌。 形状记忆材料的激活调节肌肉和瓣膜瓣之间的张力,改善心脏瓣膜小叶的接合,并减少或消除反流。

    CARDIAC VALVE IMPLANT WITH ENERGY ABSORBING MATERIAL
    20.
    发明申请
    CARDIAC VALVE IMPLANT WITH ENERGY ABSORBING MATERIAL 有权
    具有能量吸收材料的心脏瓣膜植入物

    公开(公告)号:US20080215145A1

    公开(公告)日:2008-09-04

    申请号:US12032476

    申请日:2008-02-15

    Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material, and an energy absorption enhancement material configured to absorb energy in response to an activation energy. The energy absorption enhancement material is in thermal communication with said shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration, and is configured to be implanted in the first configuration into a heart. The body member is configured to transform from the first configuration to the second configuration in response to the activation energy. The second configuration is configured to reduce a dimension of a cardiac valve annulus in the heart.

    Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置,例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能,射频能量,光能和磁能。 因此,随着身体结构改变尺寸和/或形状,可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施方案中,所述装置包括包括形状记忆材料的主体构件和被配置为响应于活化能吸收能量的能量吸收增强材料。 能量吸收增强材料与所述形状记忆材料热连通。 主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸,并且构造成以第一构造植入心脏。 身体构件被配置为响应于激活能量从第一配置变换到第二配置。 第二配置被配置为减小心脏中的心脏瓣膜环的尺寸。

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