公开(公告)号：US20210022625A1

公开(公告)日：2021-01-28

申请号：US16630663

申请日：2018-07-10

Applicant: Shiming LIN ,  BIV MEDICAL, LTD.

Inventor： Shiming LIN

IPC: A61B5/021 ,  A61B5/00 ,  A61B5/05 ,  A61B8/04

Abstract: The present invention provides a carotid blood pressure detection device, comprising: a first sensing unit, a second sensing unit, and a controller connected or coupled to the first sensing unit and the second sensing unit. The first sensing unit is disposed on a subject's neck and adjacent to a first position of the subject's carotid arteries. The second sensing unit is disposed on the subject's neck and adjacent to a second position of the subject's carotid arteries. The controller derives a mean arterial pressure of a section of the subject's carotid arteries that lies between the first position and the second position of the subject's carotid arteries from pulse wave data measured and obtained by the first sensing unit and pulse wave data measured and obtained by the second sensing unit.

公开(公告)号：US08507367B2

公开(公告)日：2013-08-13

申请号：US12667418

申请日：2008-07-03

Applicant: Xuejun Kang ,  Shu Yuan ,  Jenny Lam ,  Shiming Lin

Inventor： Xuejun Kang ,  Shu Yuan ,  Jenny Lam ,  Shiming Lin

IPC: H01L21/36 ,  H01L21/20

CPC classification number: H01L29/2003 ,  H01L21/6835 ,  H01L33/0079 ,  H01L33/0095 ,  H01L33/32 ,  H01L33/38 ,  H01L33/40 ,  H01L33/44 ,  H01L33/46 ,  H01L2221/6835 ,  H01L2933/0016

Abstract: A method of fabricating semiconductor devices is disclosed. The method comprises providing a substrate with a plurality of epitaxial layers mounted on the substrate and separating the substrate from the plurality of epitaxial layers while the plurality of epitaxial layers is intact. This preserves the electrical, optical, and mechanical properties of the plurality of epitaxial layers.

Abstract translation: 公开了制造半导体器件的方法。 所述方法包括：提供具有安装在所述衬底上的多个外延层的衬底，并且所述衬底与所述多个外延层分离，同时所述多个外延层是完整的。 这保持了多个外延层的电学，光学和机械特性。

公开(公告)号：US08110605B2

公开(公告)日：2012-02-07

申请号：US12710460

申请日：2010-02-23

Applicant: Shiming Lin ,  Chih-Kung Lee ,  Shih-Yuan Lee ,  Jim-Tong Hong ,  Ming-Chu Cheng ,  Chih-Chen Lin ,  Rong-Sin Wu ,  Shu-Fang Chu ,  Yu-Ting Chang ,  Wen-Ching Ko

Inventor： Shiming Lin ,  Chih-Kung Lee ,  Shih-Yuan Lee ,  Jim-Tong Hong ,  Ming-Chu Cheng ,  Chih-Chen Lin ,  Rong-Sin Wu ,  Shu-Fang Chu ,  Yu-Ting Chang ,  Wen-Ching Ko

IPC: A61K31/20 ,  B32B5/12

CPC classification number: C07C323/52 ,  A01N1/0215 ,  D01F1/103 ,  D06M13/252 ,  D06M16/00 ,  Y10T442/20

Abstract: The invention discloses a novel compound effective in inactivating viruses and bacteria. The compound, 2-(10-mercaptodecyl)-propanedioic acid or salts thereof, is shown to disrupt, break down or inactivate viruses and bacteria, thus suppressing infection and proliferation thereof in host cells. A method of chemically synthesizing the novel compound is also disclosed.

Abstract translation: 本发明公开了一种有效灭活病毒和细菌的新型化合物。 化合物2-（10-巯基癸基） - 丙二酸或其盐显示破坏，分解或灭活病毒和细菌，从而抑制宿主细胞的感染和增殖。 还公开了一种化学合成该新化合物的方法。

公开(公告)号：US20100171487A1

公开(公告)日：2010-07-08

申请号：US12652543

申请日：2010-01-05

Applicant: Shiming Lin ,  Shih-yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

Inventor： Shiming Lin ,  Shih-yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

IPC: G01R1/06

CPC classification number: G01N33/5438

Abstract: A method of electrosensing an antigen in a test sample using a sensor is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other and a layer of antibody immobilized on the surface of at least one of the electrodes. The antibody has specific binding reactivity with the antigen. The method comprises tethering conductivity promotion molecules over and/or distributing between the antibody-populated electrodes for improving electrical conductivity characteristics across the two electrodes, and measuring electrically across the electrodes after the test sample comes into contact with the antibody-populated electrodes. The antibody captures the antigen present in the test sample thereby altering the improved electrical conductivity characteristic across the two electrodes in which an amount representative of the altering providing an indication for electrosensing of the antigen.

Abstract translation: 公开了使用传感器对测试样品中的抗原进行电感应的方法。 传感器具有两个电极彼此电断开并物理分离，并且固定在至少一个电极的表面上的一层抗体。 抗体与抗原具有特异性结合活性。 该方法包括在抗体填充的电极之间和/或分布之间连接导电促进分子，以改善两个电极之间的导电特性，以及在测试样品与抗体填充的电极接触之后跨电极测量。 抗体捕获存在于测试样品中的抗原，从而改变跨越两个电极的改善的导电特性，其中代表改变的量提供抗原电感应的指示。

公开(公告)号：US20100170792A1

公开(公告)日：2010-07-08

申请号：US12652579

申请日：2010-01-05

Applicant: Shiming Lin ,  Shih-yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

Inventor： Shiming Lin ,  Shih-yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

IPC: G01N27/327 ,  C25B11/04

CPC classification number: G01N33/5438

Abstract: A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, and a layer of antibody is immobilized on the surface of at least one of the electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules may be tethered over and/or distributed between the antibody-populated electrodes for improving electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.

Abstract translation: 公开了一种用于在测试样品中电敏感抗原的传感器。 传感器具有两个彼此电断开并物理分离的电极，并且一层抗体被固定在至少一个电极的表面上。 抗体与抗原具有特异性结合活性。 电导率促进分子可以束缚在抗体填充的电极之间和/或分布在抗体填充的电极之间，以改善跨两个电极的导电特性。 抗体捕获与在与抗体填充的电极接触的缓冲溶液中混合的测试样品中存在的抗原。 这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

公开(公告)号：US20100170788A1

公开(公告)日：2010-07-08

申请号：US12652497

申请日：2010-01-05

Applicant: Shiming Lin ,  Shih-yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

Inventor： Shiming Lin ,  Shih-yuan Lee ,  Bor-ching Sheu ,  Chih-chen Lin ,  Panchien Lin

IPC: G01N27/327

CPC classification number: G01N33/5438

Abstract: A sensor system for electrosensing an antigen in a test sample is disclosed. The sensor system has two electrodes electrically disconnected and physically separated from each other, and a layer of antibody is immobilized on the surface of the electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules suspended in a buffer solution may be distributed over and/or between the antibody-populated electrodes for improving electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in the buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen.

Abstract translation: 公开了一种用于对测试样品中的抗原进行电感应的传感器系统。 传感器系统具有两个彼此电隔离并物理分离的电极，并且一层抗体固定在电极的表面上。 抗体与抗原具有特异性结合活性。 悬浮在缓冲溶液中的电导率促进分子可以分布在抗体填充的电极之上和/或之间，以改善两个电极之间的导电特性。 抗体捕获混合在与抗体填充电极接触的缓冲溶液中的测试样品中存在的抗原。 这改变了跨越两个电极的电导率特征，其中代表改变的量提供了抗原电感应的指示。

公开(公告)号：US20080141785A1

公开(公告)日：2008-06-19

申请号：US11790702

申请日：2007-04-27

Applicant: An-Bang Wang ,  Ming-Hsun Wu ,  Yi-Hua Wang ,  I-Chun Lin ,  Chia-Chih Chen ,  Shiming Lin

Inventor： An-Bang Wang ,  Ming-Hsun Wu ,  Yi-Hua Wang ,  I-Chun Lin ,  Chia-Chih Chen ,  Shiming Lin

IPC: G01F1/32

CPC classification number: G01F1/3218 ,  G01F1/3209 ,  G01F15/024 ,  G01F25/0007

Abstract: A high-precision vortex flow meter includes a blunt body having a predetermined dimension and being arranged inside a fluid channel to serve as a vortex shedder. The vortex flow meter also includes a temperature detecting device for detecting the vortex shedder temperature and a temperature control element for adjusting the vortex shedder temperature. A frequency measuring device is arranged in the downstream section of the blunt body for detecting the vortex shedding frequency. From the measured temperatures of the upstream fluid flow and that of the blunt body, an effective temperature and a temperature ratio are calculated. The kinematic viscosity of the fluid is looked up from database. By using the relationship between the Strouhal number and Reynolds number, the fluid flow rate is calculated. By employing different blunt body temperature, the measurement range of the flow meter can be broadly extended.

Abstract translation: 高精度涡流流量计包括具有预定尺寸的钝体并且布置在流体通道内用作涡流脱落器。 涡流流量计还包括用于检测涡流脱落器温度的温度检测装置和用于调节涡流脱落器温度的温度控制元件。 在钝体的下游部分设置有频率测量装置，用于检测涡流脱落频率。 从测量的上游流体的温度和钝体的温度，计算有效的温度和温度比。 从数据库中查找流体的运动粘度。 通过使用Strouhal数和雷诺数之间的关系，计算流体流量。 通过采用不同的体温，可以大幅度地扩展流量计的测量范围。

公开(公告)号：US20200060562A1

公开(公告)日：2020-02-27

申请号：US16465508

申请日：2017-11-29

Applicant: Shiming LIN ,  BIV MEDICAL, LTD.

Inventor： Shiming LIN

IPC: A61B5/046 ,  A61B5/022 ,  A61B5/00

Abstract: A method for detecting heart rhythm irregularities, including the steps of: measuring pulse peaks continuously over a period of time to obtain pulse peak sequence and pulse peak time interval sequence corresponding to the pulse peak sequence; and calculating the absolute value of a difference between a single pulse peak time interval in the pulse peak time interval sequence and an average value of the pulse peak time interval sequence, and determining that an irregular pulse peak (IPP) has occurred if the absolute value is larger than or equal to 15% to 25% of the average value of the pulse peak time interval sequence. A detection device using the method is also provided. This uses a non-invasive approach to detect heart rhythm irregularities such as sick sinus syndrome, irregular pulse peaks, irregular heartbeat, and atrial fibrillation, and can be applied to a sphygmomanometer or a wearable device.

公开(公告)号：US20200060560A1

公开(公告)日：2020-02-27

申请号：US16465498

申请日：2017-11-29

Applicant: Shiming LIN ,  BIV MEDICAL, LTD.

Inventor： Shiming LIN

IPC: A61B5/021

Abstract: A single-arm micro air-pressure pump device, having an air pump body and a driving unit. The air pump body includes a supporting frame, an air chamber unit coupled to a side of the supporting frame, and a swing arm provided on the air chamber unit. The driving unit is fixed on the supporting frame and has an output shaft. The output shaft is provided with an eccentric shaft and is configured to rotate the eccentric shaft, and the eccentric shaft has an end coupled to the output shaft and an opposite end coupled to the swing arm in order to drive the swing arm into a reciprocating motion between at least a proximal position and a distal position with respect to the air chamber unit. The reciprocating motion pushes a piston unit provided on one end of the swing arm and causes the air output.

公开(公告)号：US08877022B2

公开(公告)日：2014-11-04

申请号：US13165464

申请日：2011-06-21

Applicant: Shiming Lin ,  Bor-Ching Sheu ,  Luan-Yin Chang ,  Chih-Chen Lin

Inventor： Shiming Lin ,  Bor-Ching Sheu ,  Luan-Yin Chang ,  Chih-Chen Lin

IPC: G01N27/327 ,  G01N33/543

CPC classification number: G01N33/5438 ,  G01N27/3276

Abstract: Embodiments of the present disclosure set forth a biosensor for detecting a target. One example sensor includes a first electrode. The first electrode includes a first electron conducting molecule and a first probe. The first probe includes a second electron conducting molecule. The first probe is configured to bind to the target of interest in solution. The first and second electron conducting molecules are different.

Abstract translation: 本公开的实施例提出了用于检测目标的生物传感器。 一个示例性传感器包括第一电极。 第一电极包括第一电子传导分子和第一探针。 第一探针包括第二电子传导分子。 第一个探针被配置为绑定到解决方案中的感兴趣的目标。 第一和第二电子传导分子是不同的。