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15 条记录 (耗时 0.015 秒)

    Gene therapy for solid tumors, papillomas and warts
    11.
    发明授权
    Gene therapy for solid tumors, papillomas and warts 有权
    实体瘤，乳头状瘤和疣基因治疗

    公开(公告)号：US06217860B1

    公开(公告)日：2001-04-17

    申请号：US09404614

    申请日：1999-09-24

    申请人： Savio L. C. Woo ,  Shu-Hsia Chen

    发明人： Savio L. C. Woo ,  Shu-Hsia Chen

    IPC分类号： A01K6300

    CPC分类号： C12N15/86 ,  A61K9/127 ,  A61K38/00 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K38/21 ,  A61K38/45 ,  A61K38/50 ,  A61K48/00 ,  C07K14/55 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2830/008

    摘要： The present invention provides a novel method of treating localized solid tumors (metastatic carcinomas, papilloma and warts) in an individual. The method comprises delivering a suicide gene, by way of a recombinant adenoviral vector or other DNA transport system, into the solid tumor. Subsequently, a prodrug, such as the drug ganciclovir, is administered to the individual. The methods of the present invention may used to treat several different types of solid tumors including papillomas, warts, colon carcinoma, prostate cancer, breast cancer, lung cancer, melanoma, hepatoma, brain lymphoma and head and neck cancer.

    摘要翻译： 本发明提供一种在个体中治疗局部实体瘤（转移性癌，乳头瘤和疣）的新方法。 该方法包括通过重组腺病毒载体或其他DNA转运系统将自杀基因递送到实体瘤中。 随后，向个体施用前药，如药物更昔洛韦。 本发明的方法可用于治疗几种不同类型的实体瘤，包括乳头瘤，疣，结肠癌，前列腺癌，乳腺癌，肺癌，黑素瘤，肝癌，脑淋巴瘤和头颈癌。

    Gene therapy for solid tumors using adenoviral vectors comprising suicide genes and cytokine genes
    13.
    发明授权
    Gene therapy for solid tumors using adenoviral vectors comprising suicide genes and cytokine genes 失效
    使用包含自杀基因和细胞因子基因的腺病毒载体进行固体肿瘤的基因治疗

    公开(公告)号：US6066624A

    公开(公告)日：2000-05-23

    申请号：US600942

    申请日：1996-02-15

    申请人： Savio L. C. Woo ,  Shu-Hsia Chen

    发明人： Savio L. C. Woo ,  Shu-Hsia Chen

    IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/45 ,  A61K38/46 ,  A61K48/00 ,  A61P35/00 ,  C07H21/04 ,  C07K14/55 ,  C12N15/19 ,  C12N15/54 ,  C12N15/55 ,  C12N15/861

    CPC分类号： C12N15/86 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K38/21 ,  A61K38/45 ,  A61K38/50 ,  C07K14/55 ,  C12N7/00 ,  A61K38/00 ,  A61K48/00 ,  A61K9/127 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2830/008

    摘要： The present invention provides a novel method of treating localized solid tumors and papillomas in an individual, as well as metastatic carcinomas. The method comprises delivering a suicide gene, by way of a recombinant adenoviral vector or other DNA transport system, into the tumor, papilloma or wart of an individual. Subsequently, a prodrug, such as the drug gaciclovir.TM., is administered to the individual. Additionally, the present invention provides a method for treating solid tumors, papillomas, warts and metastatic carcinomas, said method comprising introducing both a suicide gene and one or more cytokine genes into the tumor, papilloma or wart of an individual, and subsequently administering a prodrug to the individual. The methods of the present invention may be used to treat several different types of cancers and papillomas, including colon carcinoma, prostate cancer, breast cancer, lung cancer, melanoma, hepatoma, brain lymphoma and head and neck cancer.

    摘要翻译： PCT No.PCT / US94 / 09784 Sec。 371日期：1996年2月15日 102（e）日期1996年2月15日PCT 1994年8月25日PCT公布。 公开号WO95 / 05835 日期1995年3月2日本发明提供一种治疗个体中局部实体瘤和乳头状瘤的新方法，以及转移性癌。 该方法包括通过重组腺病毒载体或其他DNA转运系统将自杀基因递送到个体的肿瘤，乳头状瘤或疣中。 随后，向个体施用前药，例如药物giciclovir TM。 此外，本发明提供了一种治疗实体瘤，乳头状瘤，疣和转移癌的方法，所述方法包括将自杀基因和一种或多种细胞因子基因引入个体的肿瘤，乳头状瘤或疣，随后施用前药 给个人 本发明的方法可用于治疗几种不同类型的癌症和乳头状瘤，包括结肠癌，前列腺癌，乳腺癌，肺癌，黑素瘤，肝癌，脑淋巴瘤和头颈癌。

    Method of fabricating closed cavity liquid crystal display having a plurality of cavities extending completely through insulating layer
    14.
    发明授权
    Method of fabricating closed cavity liquid crystal display having a plurality of cavities extending completely through insulating layer 失效
    制造具有完全延伸穿过绝缘层的多个空腔的封闭式液晶显示器的方法

    公开(公告)号：US5978062A

    公开(公告)日：1999-11-02

    申请号：US823389

    申请日：1997-03-24

    申请人： Bau-Jy Liang ,  Shu-Hsia Chen ,  Chung-Kuang Wei ,  Chen-Lung Kuo

    发明人： Bau-Jy Liang ,  Shu-Hsia Chen ,  Chung-Kuang Wei ,  Chen-Lung Kuo

    IPC分类号： G02F1/1333 ,  G02F1/1335 ,  G02F1/1337 ,  G02F1/1339 ,  G02F1/1343 ,  G02F1/13

    CPC分类号： G02F1/133371 ,  G02F1/133377 ,  G02F1/13394 ,  G02F1/1337 ,  G02F1/133753 ,  G02F2001/133742

    摘要： A closed-cavity liquid-crystal display is provided, which is a liquid-crystal display having a wide angle of view. The liquid-crystal display comprises: an insulator layer formed with a plurality of cavities extending completely through the insulating layer, in which liquid-crystal material is filled into the plurality of cavities; a first substrate, placed on one side of the insulator layer, in which a first electrode is formed on one side of the first substrate near the insulator layer; and a second substrate, placed on the other side of the insulator layer, in which a second electrode is formed on one side of the second substrate near the insulator layer, so that the first electrode and the second electrode are used to drive and vary the alignment of liquid-crystal molecules in the plurality of cavities. The inner circumference of the closed cavity is coated with a homeotropic alignment agent, so that the alignment of the liquid-crystal molecules is circularly symmetric, and the optical performance of the liquid-crystal display is independent of the azimuthal angle.

    摘要翻译： 提供了一种具有广角视角的液晶显示器的闭腔液晶显示器。 液晶显示器包括：绝缘体层，形成有完全延伸穿过绝缘层的多个空腔，液晶材料填充到多个空腔中; 放置在绝缘体层的一侧的第一衬底，其中第一电极形成在绝缘体层附近的第一衬底的一侧上; 以及放置在所述绝缘体层的另一侧上的第二基板，其中第二电极形成在所述第二基板的靠近所述绝缘体层的一侧上，使得所述第一电极和所述第二电极用于驱动和改变 液晶分子在多个空腔中的排列。 封闭空腔的内圆周涂覆有垂直取向剂，使得液晶分子的取向是圆形对称的，并且液晶显示器的光学性能与方位角无关。