摘要:
Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
摘要:
A new method of metallization without unwanted precipitates using a tungsten plug is achieved. Semiconductor device structures are formed in and on a semiconductor substrate. A contact hole is opened through an insulating layer to the semiconductor substrate. A glue layer is deposited conformally over the surface of the insulating layer and within the contact opening. A layer of tungsten is blanket deposited over the glue layer. The tungsten layer is etched back leaving the tungsten only within the contact opening to form a tungsten plug. The etching back leaves impurities on the surface of the glue layer. Those impurities will react with water or air to form precipitates. The precipitates are removed using a wet chemical etch. The substrate is post treated with argon ion sputtering to prevent future formation of precipitates. A second metal layer is deposited over the tungsten plug and the glue layer to complete the tungsten plug metallization without unwanted precipitates in the fabrication of an integrated circuit.
摘要:
The present invention relates to 10-desacetoxy-11,12-dihydrotaxol-10,12(18)-diene derivatives which are useful as antitumor agents and as intermediates for the preparation of 10-desacetoxytaxol. Also disclosed is a novel process for the preparation of 10-desacetoxytaxol which comprises treating hydroxy protected 10-deacetyltaxol with 1,1,2-trifluoro-2-chlorotriethylamine followed by catalytic hydrogenation.
摘要:
This invention relates to a fluorinated taxol of formula I ##STR1## in which R.sup.1 is benzoyl or t-butyloxycarbonyl; R.sup.2 is acetoxy, hydrogen or hydroxy; and the wavy line indicates either the .alpha.- or the .beta.-configuration.Further provided by this invention are pharmaceutical formulations and useful intermediates for the fluorinated taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.
摘要:
A wheel cylinder adjuster includes a rotary unit and a driving unit connected with the rotary unit. The rotary unit includes a rotary disk, a fixing member, two positioning members, a resilient ring, a restriction member and a clip. The rotary disk has a guide groove designed in a shape containing two semi-ovals. Two stepped slots are defined through the fixing member and the positioning members extend through the two stepped slots. Each positioning member has a guide tip which is located in the guide groove. The resilient ring is mounted to the positioning members and the tubular portion. The rotary disk is rotated and the guide tips of the positioning members more in the stepped slots so as to adjust the distance between the positioning members so as to be operated to different sizes of the wheel cylinders.
摘要:
An oil pipe stopper includes an upper clamping body, a lower clamping body, and an elastic member. The upper clamping body has a central portion with an upper post, two downwardly slanting portions, and two clamping portions. The clamping portions of the upper clamping body are provided with a first stopping member and an engagement groove. The lower clamping body has a central portion with a lower post, two upwardly slanting portions, and two clamping portions. The lower post is telescopically connected with the upper post. The clamping portions of the lower clamping body are provided with a second stopping member and a third stopping member. The downwardly and upwardly slanting portions are crossed such that the first stopping member faces the second stopping member while the engagement groove faces the third stopping member. The elastic member is mounted between the upper clamping body and the lower clamping body.
摘要:
The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要:
The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要:
The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
摘要:
The present invention relates to a hydrophilic surface structure of the non-hydrophilic substrate and the manufacturing method for using the same. The hydrophilic substrate surface structure is fabricated by forming an amphiphilic polymer layer, a cross-linked stacking layer, and a hydrophilic layer in sequence on the surface of a non-hydrophilic substrate. For example, the hydrophobic surface of poly(dimethylsiloxane) (PDMS) can be made from hydrophobic to hydrophilic and the hydrophilicity can be retained for a long period of time and resist protein adsorption. The hydrophilic thin films give long term stability to the PDMS surface by resisting hydrophobicity recovery, which is the major problem with PDMS. The disclosed method can further be used in the immobilization of protein and other molecules. This method can also be used for modifying other substrates which suffer problems of surface instability.