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30 条记录 (耗时 0.023 秒)

    Method and apparatus for locating a faulty device in a computer system
    11.
    发明授权
    Method and apparatus for locating a faulty device in a computer system 有权
    用于在计算机系统中定位故障设备的方法和装置

    公开(公告)号：US07096387B2

    公开(公告)日：2006-08-22

    申请号：US10094434

    申请日：2002-03-08

    申请人： Paul Durrant ,  Stephen R Hanson ,  David S Gordon ,  Hossein Moiin

    发明人： Paul Durrant ,  Stephen R Hanson ,  David S Gordon ,  Hossein Moiin

    IPC分类号： G06F11/00

    CPC分类号： G06F11/0727 ,  G06F11/079

    摘要： A computer system compnses a processor (2), memory (4) and a plurality of devices (6, 8, 12), the processor (2) and the memory (4) being operable to effect the operation of a fault response processor (AFR), and a device driver (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL) for each of the devices. The fault response processor (AFR) is operable to generate a model which represents the processor (2), the memory (4) and the devices (6, 8, 12) of the computer system and the inter-connection of the processor (2), memory (4) and the devices (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL). The device driver (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL) for each of the devices (6, 8, 12) is arranged, consequent upon a change of operational status of the device, to generate fault report data indicating whether the change of status was caused internally within the device or externally by another connected device. The devices of the computer system may be formed as a plurality of Field Replaceable Units (FRU). The fault response processor (AFR) is operable, consequent upon receipt of the fault reports from the device drivers (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL) to estimate the location of a FRU containing a faulty device by applying the fault indication to the model. In other embodiments the fault report data includes direction information indicating a connection between the device and the other connected device which caused the external fault. Having identified the faulty device the FRU may be replaced, thereby minimizing down time of the computer system.

    摘要翻译： 计算机系统包括处理器（2），存储器（4）和多个设备（6,8,12），处理器（2）和存储器（4）可操作以实现故障响应处理器（ AFR）和每个设备的设备驱动程序（GRAPHICS，NETWORK，H2IO，IO2L，SERIAL）。 故障响应处理器（AFR）可操作以产生表示计算机系统的处理器（2），存储器（4）和设备（6,8,12）的模型以及处理器（2）的互连 ），内存（4）和设备（GRAPHICS，NETWORK，H2IO，IO2L，SERIAL）。 随着设备的运行状态的改变，布置了每个设备（6,8,12）的设备驱动程序（GRAPHICS，NETWORK，H2IO，IO2L，SERIAL），以产生指示是否改变 状态是在设备内部或外部由另一个连接的设备引起的。 计算机系统的装置可以形成为多个现场可更换单元（FRU）。 故障响应处理器（AFR）可以在从设备驱动程序（GRAPHICS，NETWORK，H2IO，IO2L，SERIAL）接收到故障报告后进行操作，以通过将故障指示应用于故障指示来估计包含故障设备的FRU的位置 模型。 在其他实施例中，故障报告数据包括指示引起外部故障的设备与另一连接设备之间的连接的方向信息。 识别出故障设备后，可以更换FRU，从而最大程度减少计算机系统的停机时间。

    Device for local drug delivery and methods for using the same
    13.
    发明授权
    Device for local drug delivery and methods for using the same 失效
    用于局部药物输送的装置及其使用方法

    公开(公告)号：US5399352A

    公开(公告)日：1995-03-21

    申请号：US46622

    申请日：1993-04-14

    申请人： Stephen R. Hanson

    发明人： Stephen R. Hanson

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61M25/00 ,  A61M25/088 ,  A61M37/00 ,  A61F2/04

    CPC分类号： A61F2/06 ,  A61F2/064 ,  A61M25/0021 ,  A61M37/00 ,  A61F2250/0067 ,  A61M2025/0063 ,  A61M25/0041

    摘要： A device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first clement capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.

    摘要翻译： 一种用于将物质局部递送到哺乳动物体内的天然组织导管中的装置，其具有能够接触导管的内腔的第一部件和覆盖第一元件的第二元件，形成在第一元件和第二元件之间的储存器 第二元件，储存器的内部能够与管道流体连通，使得放置在储存器中的物质被输送到管道中。 还提供了利用本发明的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。

    Antithrombotic thrombin variants
    15.
    发明授权
    Antithrombotic thrombin variants 有权
    抗血栓凝血酶变体

    公开(公告)号：US07223583B2

    公开(公告)日：2007-05-29

    申请号：US10699393

    申请日：2003-10-31

    申请人： Andras Gruber ,  Stephen R. Hanson ,  Enrico De Cera

    发明人： Andras Gruber ,  Stephen R. Hanson ,  Enrico De Cera

    IPC分类号： C12N9/64 ,  A61K38/48

    CPC分类号： C12N9/6464 ,  A61K38/00 ,  C12N9/6429 ,  C12Q1/40 ,  C12Y304/21005 ,  C12Y304/21069 ,  G01N33/86

    摘要： The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of fibrinogen cleavage activity. The present invention further relates to variant polypeptides that may be cleaved to yield active thrombin variants. The present invention also relates to methods of inhibiting thrombus formation in an animal or human subject by delivering an antithrombotic variant thrombin of the present invention to the blood of the subject. The present invention relates also to methods that use the novel variant thrombins for determining the level of protein C activation in a blood sample, or the thrombogenic potential of a patient.

    摘要翻译： 本发明涉及能够蛋白水解活化蛋白C但基本上不含纤维蛋白原裂解活性的凝血酶或其片段的新型抗血栓形成变体。 本发明还涉及可被切割以产生活性凝血酶变体的变体多肽。 本发明还涉及通过将本发明的抗血栓形成变体凝血酶递送至受试者的血液来抑制动物或人受试者中血栓形成的方法。 本发明还涉及使用新型变体血栓素来测定血液样品中蛋白C活化水平或患者血栓形成潜力的方法。

    Polymeric drug formulations
    16.
    发明授权
    Polymeric drug formulations 有权

    公开(公告)号：US07101840B2

    公开(公告)日：2006-09-05

    申请号：US10177097

    申请日：2002-06-21

    申请人： Stephen Brocchini ,  Stephen R. Hanson ,  Joachim B. Kohn

    发明人： Stephen Brocchini ,  Stephen R. Hanson ,  Joachim B. Kohn

    IPC分类号： C07K14/00 ,  C07K16/00

    CPC分类号： A61K9/146 ,  A61K9/2031 ,  A61K9/204 ,  A61K9/7007

    摘要： A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and with a poly(alkylene oxide), in a solvent system capable of forming a homogeneous solution of the drug, the tissue-compatible polymer and the poly(alkylene oxide), after which the solution is added to a non-solvent for the drug, the tissue-compatible polymer and the poly(alkylene oxide), so that a microdomain-separated solid co-precipitate of the drug, the tissue-compatible polymer and the poly(alkylene oxide) is formed, wherein the poly(alkylene oxide) is blended in an amount effective to form phase-separated microdomains in said co-precipitate.

    Method of inhibiting platelet dependent arterial thrombosis
    19.
    发明授权
    Method of inhibiting platelet dependent arterial thrombosis 失效
    抑制血小板依赖性动脉血栓形成的方法

    公开(公告)号：US4929602A

    公开(公告)日：1990-05-29

    申请号：US275330

    申请日：1988-11-22

    申请人： Laurence A. Harker ,  Stephen R. Hanson

    发明人： Laurence A. Harker ,  Stephen R. Hanson

    IPC分类号： A61K38/00 ,  A61K38/06 ,  A61K38/46 ,  A61P7/02 ,  A61P9/10 ,  C07K5/08

    CPC分类号： A61K38/06

    摘要： The present invention contemplates a method of preventing platelet dependent arterial thrombosis using a halogen-methyl ketone-containing peptide represented by Formula (1) as shown in FIG. 1, or a hydrohalic addition product thereof. More particularly, the present invention provides improved methods for inhibiting arterial restenosis, hemodialysis and the like.

    摘要翻译： 本发明考虑使用如图1所示的式（1）所示的含有卤素 - 甲基酮的肽来预防血小板依赖性动脉血栓形成的方法。 1，或其氢卤加成产物。 更具体地，本发明提供了用于抑制动脉再狭窄，血液透析等的改进方法。