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    Graft having microporous membrane for uniform fluid infusion
    1.
    发明授权
    Graft having microporous membrane for uniform fluid infusion 有权
    具有用于均匀流体输注的微孔膜的移植物

    公开(公告)号：US08721711B2

    公开(公告)日：2014-05-13

    申请号：US11765915

    申请日：2007-06-20

    申请人： Stephen R. Hanson

    发明人： Stephen R. Hanson

    IPC分类号： A61F2/06

    CPC分类号： A61M1/3655 ,  A61F2/064 ,  A61F2250/0068

    摘要： Embodiments of the present invention provide a device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first element capable of contacting the lumen of the conduit and a second element which overlays first element, a reservoir being formed between the first element and the second element, the interior of the reservoir being capable of fluid communication with the conduit such that a substance placed in the reservoir is delivered into the conduit. In embodiments, the first element may be fully or partially microporous or a separate intermediate microporous membrane may be provided. Also provided are methods of mixing or moving a drug within a reservoir using various mixing elements. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing a device in accordance with embodiments of the present invention.

    摘要翻译： 本发明的实施方案提供了一种用于将物质局部递送到哺乳动物体内的天然组织导管中的装置，其具有能够接触导管的内腔的第一元件和覆盖第一元件的第二元件，形成的储存器 在第一元件和第二元件之间，储存器的内部能够与管道流体连通，使得放置在储存器中的物质被输送到管道中。 在实施方案中，第一元素可以是完全或部分微孔的，或者可以提供单独的中间微孔膜。 还提供了使用各种混合元件在储存器内混合或移动药物的方法。 还提供了使用根据本发明的实施方案的装置将物质局部输送到哺乳动物体内的天然组织导管中的方法。

    DRUG DELIVERY CUFF
    2.
    发明申请
    DRUG DELIVERY CUFF 有权
    药物递送罐

    公开(公告)号：US20100268188A1

    公开(公告)日：2010-10-21

    申请号：US12747048

    申请日：2008-12-12

    申请人： Stephen R. Hanson

    发明人： Stephen R. Hanson

    IPC分类号： A61M31/00 ,  A61M1/00

    CPC分类号： A61M31/002 ,  A61F2/06 ,  A61F2/064 ,  A61F2250/0067 ,  A61M5/14276

    摘要： Embodiments provide a drug delivery cuff including a drug reservoir. In an embodiment, an integrated drug pump may be provided. A drug delivery cuff in accordance with an embodiment may be placed around any suitable vascular graft (e.g., ePTFE) or directly around any natural tissue conduit (e.g., perivascularly), at any position along the graft/conduit or overlapping a graft and conduit, either at the time of graft surgical placement or separate therefrom.

    摘要翻译： 实施例提供了包括药物储存器的药物递送袖带。 在一个实施例中，可以提供集成的药物泵。 根据实施例的药物输送袖带可以放置在任何合适的血管移植物（例如ePTFE）周围或者在任何天然组织导管周围（例如血管周围）放置在沿着移植物/管道的任何位置处或与移植物和导管重叠， 无论是在移植手术放置时还是从其分离。

    Method and mechanism for generating a live snapshot in a computing system
    4.
    发明授权
    Method and mechanism for generating a live snapshot in a computing system 有权
    在计算系统中生成实时快照的方法和机制

    公开(公告)号：US07100006B2

    公开(公告)日：2006-08-29

    申请号：US10051498

    申请日：2002-01-18

    申请人： Paul Durrant ,  Stephen R Hanson

    发明人： Paul Durrant ,  Stephen R Hanson

    IPC分类号： G06F12/16

    CPC分类号： G06F17/30309

    摘要： A method and mechanism for generating a snapshot in a computing system. On initiating a snapshot of a first storage, the content of a portion of the first storage that includes at least one block is copying to snapshot storage and a copied indication for each copied block is recording in a copy map. Responsive to any write request to a block for which no copied indication has been recorded in the copy map, the content of the block is copied to the snapshot storage, prior to writing to that block. The content of other blocks for which no copied indication has been recorded in the copy map is successively copied to the snapshot storage. A copied indication for each copied block is recorded in the copy map. The successive copying can be performed as a background task.

    摘要翻译： 一种用于在计算系统中生成快照的方法和机制。 在启动第一存储器的快照时，包括至少一个块的第一存储器的一部分的内容是复制到快照存储器，并且每个复制块的复制指示是在复制映射中进行记录。 响应于对复制图中没有复制指示的块的任何写入请求，在写入该块之前将块的内容复制到快照存储器。 在复制图中没有复制指示的其他块的内容被连续复制到快照存储器中。 每个复制块的复制指示记录在复制图中。 可以执行连续复制作为后台任务。

    Polymeric drug formulations
    5.
    发明授权
    Polymeric drug formulations 失效
    聚合药物制剂

    公开(公告)号：US07005454B2

    公开(公告)日：2006-02-28

    申请号：US09257145

    申请日：1999-02-24

    申请人： Stephen Brocchini ,  Stephen R. Hanson ,  Joachim B. Kohn

    发明人： Stephen Brocchini ,  Stephen R. Hanson ,  Joachim B. Kohn

    IPC分类号： A61K47/30 ,  A61K47/32 ,  A61K47/34

    CPC分类号： A61K9/146 ,  A61K9/2031 ,  A61K9/204 ,  A61K9/7007

    摘要： Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.

    摘要翻译： 含水溶性药物的非释放单相分散体在水不溶性组织相容的聚合物基质中的聚合药物制剂。 还公开了含有水溶性药物和水不溶性组织相容聚合物基质的单相分散体的聚合药物制剂，以及与组织相容的聚合物不可混溶的第二种相位破坏性聚合物，并且是 存在的量足以在组织相容性聚合物基质中形成第二聚合物的相分离微区，使得来自组织相容性聚合物基质的水溶性药物的释放速率与第二聚合物的量相关 。 还描述了制备聚合物药物制剂的方法，以及利用聚合物药物制剂的用于位点特异性药物递送的方法。

    Device drivers configured to monitor device status
    10.
    发明授权
    Device drivers configured to monitor device status 有权
    配置为监视设备状态的设备驱动程序

    公开(公告)号：US07137039B2

    公开(公告)日：2006-11-14

    申请号：US10075140

    申请日：2002-02-14

    申请人： Paul Durrant ,  Stephen R Hanson ,  David S Gordon ,  Jeremy Harris

    发明人： Paul Durrant ,  Stephen R Hanson ,  David S Gordon ,  Jeremy Harris

    IPC分类号： G06F11/00

    CPC分类号： G06F11/0772 ,  G06F11/0745 ,  G06F11/079

    摘要： A device driver (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL) for use in a computer system comprising a processor (P), memory (M) and a device (GRAPHICS, NETWORK, H2IO, IO2L, SERIAL) operatively coupled to the computer system, the device driver being operable to control the device to monitor an operational status of the device, and consequent upon a change in the operational status to generate a fault report data indicating whether the change of status was caused internally within the device or externally by another connected device which caused the change of operational status to occur. The fault reports may also include an indication of the operational status of the device. Furthermore, if the fault report data indicates that the change of status was caused externally, the device driver may generate fault direction information indicative of an apparent direction on a connection between the device and the other device suspected as causing the indicated external fault. By providing an indication as to whether a fault has occurred internally or externally, and if externally, a relative direction on a data path from which the fault is perceived, a fault response processor can estimate the location of a faulty device of the computer system with improved accuracy.

    摘要翻译： 一种用于计算机系统的设备驱动程序（GRAPHICS，NETWORK，H 2 IO，IO 2 L，SERIAL），包括处理器（P），存储器（M）和设备（GRAPHICS，NETWORK，H 2 IO，IO 2 L ，SERIAL），其可操作地耦合到所述计算机系统，所述设备驱动器可操作以控制所述设备以监视所述设备的操作状态，并且随着所述操作状态的改变而产生故障报告数据，以指示状态变化是否为 在设备内部引起或外部由另一个连接的设备导致操作状态发生变化。 故障报告还可以包括设备的操作状态的指示。 此外，如果故障报告数据指示状态的变化是由外部引起的，则设备驱动程序可能产生故障方向信息，指示设备与怀疑引起指示的外部故障的其他设备之间的连接上的明显方向。 通过提供关于内部或外部故障是否发生的指示，以及如果在外部，在感知到故障的数据路径上的相对方向，故障响应处理器可以估计计算机系统的故障设备的位置， 提高准确度。