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11.发明授权Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor 有权二氨基 - 吡啶，嘧啶和组胺H4受体的哒嗪调节剂公开(公告)号：US08841287B2
公开(公告)日：2014-09-23
申请号：US12997567
申请日：2009-06-11
Applicant: Hui Cai , Frank Chavez , Paul J. Dunford , Andrew J. Greenspan , Steven P. Meduna , Jorge A. Quiroz , Brad M. Savall , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei , Ronald L. Wolin , Xiaohu Zhang
Inventor： Hui Cai , Frank Chavez , Paul J. Dunford , Andrew J. Greenspan , Steven P. Meduna , Jorge A. Quiroz , Brad M. Savall , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei , Ronald L. Wolin , Xiaohu Zhang
IPC: A01N43/00
CPC classification number: C07D213/74 , A61K31/44 , A61K31/50 , C07D237/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D487/04
Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 可用作H 4受体调节剂的二氨基 - 吡啶，嘧啶和哒嗪化合物，以及用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和 瘙痒症
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公开(公告)号：US07452890B2
公开(公告)日：2008-11-18
申请号：US11517040
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/497 , C07D401/14 , C07D413/14 , C07D403/14
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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13.发明申请公开(公告)号：US20080200454A1
公开(公告)日：2008-08-21
申请号：US12031010
申请日：2008-02-14
Applicant: Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
Inventor： Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
IPC: A61K31/437 , A61P37/00 , A61P29/00 , A61P1/00 , A61P25/00 , A61P35/00 , A61K31/496 , A61K31/541 , A61K31/55 , A61P17/00 , A61P3/10 , A61P11/00 , C07D471/04 , A61K31/53
CPC classification number: C07D471/04 , C07D519/00
Abstract: Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
Abstract translation: 描述了碳连接的四氢 - 吡唑并 - 吡啶化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。
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公开(公告)号：US07309703B2
公开(公告)日：2007-12-18
申请号：US09928122
申请日：2001-08-10
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/4353 , C07D471/04
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
Abstract translation: 描述了取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号：US07265102B2
公开(公告)日：2007-09-04
申请号：US11147923
申请日：2005-06-08
Applicant: Hui Cai , James P. Edwards , Steven P Meduna , Barbara A. Pio , Jianmei Wei
Inventor： Hui Cai , James P. Edwards , Steven P Meduna , Barbara A. Pio , Jianmei Wei
IPC: A61K31/4155 , A61P11/06 , C07D401/14 , C07D403/06
CPC classification number: C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/55 , C07D401/14 , C07D409/14 , C07D471/04 , C07D471/14
Abstract: Substituted pyrazoles of general formula methods of manufacturing them, compositions containing them, and methods of using them to, for example, treat autoimmune diseases mediated by cathepsin S, and inhibit cathepsin S activity, are described.
Abstract translation: 描述了制备它们的通式的取代吡唑，含有它们的组合物，以及将其用于例如治疗由组织蛋白酶S介导的自身免疫性疾病和抑制组织蛋白酶S活性的方法。
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Patent Agency Ranking
公开(公告)号：US06953793B2
公开(公告)日：2005-10-11
申请号：US09927324
申请日：2001-08-10
Applicant: Christopher R. Butler , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Clark A. Sehon , Kevin L. Tays , Jianmei Wei
Inventor： Christopher R. Butler , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Clark A. Sehon , Kevin L. Tays , Jianmei Wei
IPC: C07D401/14 , A61K31/275 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/549 , A61K31/55 , A61P11/06 , A61P29/00 , A61P37/06 , A61P43/00 , C07D413/14 , C07D471/04 , C07D471/14 , C07D519/00 , C07D403/06
CPC classification number: C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/454 , A61K31/495 , A61K31/55 , C07D471/04 , C07D471/14
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
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公开(公告)号：US06583155B2
公开(公告)日：2003-06-24
申请号：US10075692
申请日：2002-02-13
Applicant: Christopher R. Butler , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Clark A. Sehon , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
Inventor： Christopher R. Butler , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Clark A. Sehon , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
IPC: A61K3144
CPC classification number: A61K31/4745 , A61K31/00 , A61K31/13 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55
Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
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18.发明申请Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor 有权二氨基 - 吡啶，嘧啶和组胺H4受体的哒嗪调节剂公开(公告)号：US20110092474A1
公开(公告)日：2011-04-21
申请号：US12997567
申请日：2009-06-11
Applicant: Hui Cai , Frank Chavez , Paul J. Dunford , Andrew J. Greenspan , Steven P. Meduna , Jorge A. Quiroz , Brad M. Savall , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei , Ronald L. Wolin , Xiaohu Zhang
Inventor： Hui Cai , Frank Chavez , Paul J. Dunford , Andrew J. Greenspan , Steven P. Meduna , Jorge A. Quiroz , Brad M. Savall , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei , Ronald L. Wolin , Xiaohu Zhang
IPC: A61K31/4439 , C07D401/04 , C07D405/14 , A61K31/496 , C07D403/04 , A61K31/506 , C07D401/14 , A61K31/501 , C07D487/04 , A61K31/551 , A61K31/444 , C07D237/20 , A61K31/50 , A61P29/00 , A61P37/08 , A61P17/00 , A61P37/06 , A61P37/04 , A61P11/06 , A61P9/10 , A61P25/00 , A61P27/02 , A61P1/00 , A61P17/06 , A61P17/04 , A61P11/00 , A61P3/10 , A61P13/12 , A61P7/06 , A61P1/16 , A61P25/24 , A61P25/18 , A61P25/22 , A61P25/04
CPC classification number: C07D213/74 , A61K31/44 , A61K31/50 , C07D237/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D487/04
Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 可用作H 4受体调节剂的二氨基 - 吡啶，嘧啶和哒嗪化合物，以及用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和 瘙痒症
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公开(公告)号：US07772236B2
公开(公告)日：2010-08-10
申请号：US12220539
申请日：2008-07-24
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/497 , A61K31/24 , A61K31/505
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
Abstract translation: 取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫疾病的方法。
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公开(公告)号：US07388011B2
公开(公告)日：2008-06-17
申请号：US11517171
申请日：2006-09-07
Applicant: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
Inventor： Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC: A61K31/495 , C07D471/04
CPC classification number: C07D231/12 , C07D471/04
Abstract: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
Abstract translation: 取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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