公开(公告)号：US20050255475A1

公开(公告)日：2005-11-17

申请号：US10528863

申请日：2003-09-25

Applicant: Shiv Kumar ,  Chung-Yuan Chen ,  Sudhakar Rao

Inventor： Shiv Kumar ,  Chung-Yuan Chen ,  Sudhakar Rao

IPC: C07D311/82 ,  C07D405/14 ,  C07D473/02 ,  C07D487/04 ,  C07D491/22 ,  C09B11/04 ,  C09B11/08 ,  C09B11/24 ,  C12Q1/68

CPC classification number: C09B11/08 ,  C07D311/82 ,  C07D405/14 ,  C07D487/04 ,  C09B11/04 ,  C09B11/24 ,  C12Q1/6869 ,  C12Q2527/125

Abstract: The present invention relates to a novel set of four fluorescently labeled dye terminators. Two of them are single dye labeled terminators and the other two dye terminators are based on fluorescent resonance energy transfer (FRET). The FRET dye terminators are generated from the 4′,5′-bis-aminomethylfluorescein. Of the two amino groups of the donor dye, 4′,5′-bis-aminomethylfluorescein, one amino group is used to attach the acceptor dye, and the other amino group is used to attach the dideoxynucleoside-5′-triphosphate. Their preparation, energy transfer efficiency, and use as labels, specifically, in DNA sequencing reactions is disclosed.

Abstract translation: 本发明涉及一组四种荧光标记的染料终止剂。 其中两个是单染色标记终止子，另外两个染料终止子是基于荧光共振能量转移（FRET）。 FRET染料终止子由4'，5'-双氨基甲基荧光素生成。 在供体染料的两个氨基中，4'，5'-双氨基甲基荧光素，1个氨基用于连接受体染料，而另一个氨基用于连接双脱氧核苷-5'-三磷酸。 公开了它们的制备，能量转移效率和用作标记，特别是在DNA测序反应中。

公开(公告)号：US20050104794A1

公开(公告)日：2005-05-19

申请号：US10714421

申请日：2003-11-14

Applicant: Sudhakar Rao ,  James Wang ,  Joel Fink

Inventor： Sudhakar Rao ,  James Wang ,  Joel Fink

IPC: H01Q3/26 ,  H01Q13/02 ,  H01Q25/00 ,  H01Q13/00

CPC classification number: H01Q3/2658 ,  H01P1/2131 ,  H01Q5/55 ,  H01Q13/0208 ,  H01Q13/0258 ,  H01Q25/007

Abstract: An antenna comprising a reflector having a reflector surface profile for reflecting a plurality of signals comprising a plurality of communication bands; a multi-depth corrugated horn assembly for receiving the signal comprising the plurality of communication bands; a stepped waveguide coupled to the corrugated horn; a first polarizer coupled to the stepped waveguide for separating a first communication band from the plurality of communication bands; a second polarizer coupled to the stepped waveguide for separating a second communication band from the plurality of communication bands; and a third polarizer coupled to the stepped waveguide for separating a third communication band from the plurality of communication bands. The antenna can simultaneously operate in the K, Ka and EHF frequency bands. Extension of this antenna to include five separate frequency bands is demonstrated.

公开(公告)号：US08975389B2

公开(公告)日：2015-03-10

申请号：US13203927

申请日：2010-03-02

Applicant: Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Alexander V. Kelin ,  Sudhakar Rao Takkellapati ,  Shigeo Matsuda

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Alexander V. Kelin ,  Sudhakar Rao Takkellapati ,  Shigeo Matsuda

IPC: C07H21/02 ,  C07H21/04 ,  C07H19/04 ,  C07H19/10 ,  C07H19/073 ,  C07H19/173 ,  C07H19/20

CPC classification number: C12N15/113 ,  C07H19/073 ,  C07H19/10 ,  C07H19/173 ,  C07H19/20 ,  C07H21/00 ,  C07H21/02 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336

Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

Abstract translation: 本发明提供式（1）的核苷和包含至少一种式（2）的核苷的寡核苷酸：本发明的另一方面涉及抑制细胞中基因表达的方法，所述方法包括（a）使 本发明的寡核苷酸与细胞; 和（b）将来自步骤（a）的细胞维持足以获得靶基因的mRNA降解的时间。

公开(公告)号：US07382743B1

公开(公告)日：2008-06-03

申请号：US11029364

申请日：2005-01-06

Applicant: Sudhakar Rao ,  Mysore Sheshadri ,  Jim Wang

Inventor： Sudhakar Rao ,  Mysore Sheshadri ,  Jim Wang

IPC: H04B7/185 ,  H04Q7/00

CPC classification number: H01Q25/007 ,  H01Q1/288

Abstract: Antenna system and methodology for producing multiple interleaved beams using a hybrid frequency-reuse scheme. In particular, depending on the traffic demand in specific coverage areas, some beams are assigned with frequency channels in accordance with a 4-cell frequency-reuse scheme, and the other beams are assigned with frequency channels in accordance with a 7-cell frequency-reuse scheme. The antenna system has multiple feeds divided into clusters, and a number of reflectors fed by respective feed clusters and configured to form one beam for each of the feeds.

Abstract translation: 使用混合频率重用方案产生多个交错波束的天线系统和方法。 特别地，根据特定覆盖区域的业务需求，根据4小区频率复用方案，一些波束被分配频率信道，其他波束根据7小区频率 - 重用方案。 天线系统具有分成簇的多个馈电，以及由相应的馈电簇馈送的多个反射器，并且被配置为为每个馈送形成一个光束。

公开(公告)号：US20070182654A1

公开(公告)日：2007-08-09

申请号：US11480497

申请日：2006-07-05

Applicant: Sudhakar Rao ,  Stephen Peck ,  Minh Tang ,  Jim Wang ,  David Brown

Inventor： Sudhakar Rao ,  Stephen Peck ,  Minh Tang ,  Jim Wang ,  David Brown

IPC: H01Q13/00

CPC classification number: H01Q19/12 ,  H01Q19/10 ,  H01Q19/17 ,  H01Q25/007

Abstract: An antenna system for generating and configuring at least one defocused beam is provided. The antenna system includes a reflector having a focal plane and a non-parabolic curvature for forming the at least one defocused beam, and a plurality of feed antennas that illuminate the reflector. Each feed antenna is disposed in the focal plane of the reflector. The antenna system further includes at least one incoming signal dividing network that divides at least one incoming signal into a plurality of sub-signals, each corresponding to one of the feed antennas, a plurality of variable phase shifters, each receiving one of the sub-signals from the incoming signal dividing network and phase shifting the sub-signal to generate a corresponding phase-shifted sub-signal, and a plurality of fixed-amplitude amplifiers, at least one corresponding to each of the feed antennas. The at least one amplifier for each feed antenna amplifies the corresponding phase-shifted sub-signal to generate an amplified phase-shifted sub-signal which is provided to the corresponding feed antenna.

Abstract translation: 提供了一种用于产生和配置至少一个散焦光束的天线系统。 天线系统包括具有用于形成至少一个散焦光束的焦平面和非抛物线曲率的反射器，以及照射反射器的多个馈送天线。 每个馈送天线设置在反射器的焦平面中。 天线系统还包括至少一个输入信号分配网络，其将至少一个输入信号分成多个子信号，每个子信号对应于馈送天线之一，多个可变移相器，每个接收子载波中的一个子信号， 来自输入信号分割网络的信号和相移子信号以产生对应的相移子信号，以及多个固定幅度放大器，至少一个对应于每个馈送天线。 用于每个馈送天线的至少一个放大器放大对应的相移子信号以产生提供给相应的馈电天线的放大的相移子信号。

公开(公告)号：US06535174B2

公开(公告)日：2003-03-18

申请号：US09467637

申请日：1999-12-20

Applicant: Sudhakar Rao ,  Arun Bhattacharyya

Inventor： Sudhakar Rao ,  Arun Bhattacharyya

IPC: H01Q1300

CPC classification number: H01Q25/04 ,  H01Q13/025

Abstract: An antenna apparatus that has an increased efficiency, and a method for increasing the efficiency of multi-mode antenna feed horns, is disclosed. The method comprises the steps of exciting, within the antenna, a desired transmission mode and an undesired transmission mode of the signal to be transmitted, and converting, within the antenna, power within the undesired transmission mode into power for the desired transmission mode of the signal to be transmitted. An antenna apparatus in accordance with the present invention comprises a feed horn having an input opening, an aperture, and a cavity, disposed between the input opening and the aperture, for suppressing an undesired transmission mode of the antenna and exciting a desired transmission mode of the antenna.

Abstract translation: 公开了一种提高效率的天线装置和提高多模式天线馈电喇叭的效率的方法。 该方法包括以下步骤：在天线内激发要发送的信号的期望的传输模式和不期望的传输模式，并且在天线内将在不期望的传输模式内的功率转换成用于所需传输模式的功率 要发送的信号。 根据本发明的天线装置包括一个馈电喇叭，其具有设置在输入开口和孔之间的输入开口，孔径和空腔，用于抑制天线的不期望的传输模式并激发所需的传输模式 天线。

公开(公告)号：US06463281B1

公开(公告)日：2002-10-08

申请号：US09552333

申请日：2000-04-19

Applicant: John L. Norin ,  Sudhakar Rao ,  Paul Regulinski ,  Romulo Pontual

Inventor： John L. Norin ,  Sudhakar Rao ,  Paul Regulinski ,  Romulo Pontual

IPC: H04Q720

CPC classification number: H04B7/2041 ,  H04B7/18523

Abstract: A satellite broadcast system and method, particularly useful for television signals, allows for local as well as nationwide broadcast service by allocating greater satellite resources to the more important local service areas. This is accomplished by broadcasting a non-uniform pattern of local service beams and designing the system to establish different service area priorities through factors such as the individual beam powers, sizes, roll-off characteristics and peak-to-edge power differentials. Frequency reuse is enhanced by permitting a certain degree of cross-beam interference, with lower levels of interference established for the more important service areas.

公开(公告)号：US06434384B1

公开(公告)日：2002-08-13

申请号：US09160681

申请日：1998-09-25

Applicant: John L. Norin ,  Sudhakar Rao ,  Paul Regulinski

Inventor： John L. Norin ,  Sudhakar Rao ,  Paul Regulinski

IPC: H04Q720

CPC classification number: H04B7/2041 ,  H04B7/18523

Abstract: A satellite broadcast system and method, particularly useful for television signals, allows for local as well as nationwide broadcast service by allocating greater satellite resources to the more important local service areas. This is accomplished by broadcasting a non-uniform pattern of local service beams and designing the system to establish different service area priorities through factors such as the individual beam powers, sizes, roll-off characteristics and peak-to-edge power differentials. Frequency reuse is enhanced by permitting a certain degree of cross-beam interference, with lower levels of interference established for the more important service areas.

Abstract translation: 对于电视信号特别有用的卫星广播系统和方法允许通过将更多的卫星资源分配给更重要的本地服务区域来进行本地和全国的广播服务。 这是通过广播本地业务波束的不均匀模式和设计系统来实现的，以通过诸如各个波束功率，大小，滚降特性和峰值到边缘功率差的因素建立不同的服务区域优先级。 通过允许一定程度的横梁干扰，为更重要的服务区域建立较低的干扰水平来增强频率重用。

公开(公告)号：US08315557B1

公开(公告)日：2012-11-20

申请号：US12823841

申请日：2010-06-25

Applicant: Sudhakar Rao ,  Jim Wang ,  Chih-Chien Hsu

Inventor： Sudhakar Rao ,  Jim Wang ,  Chih-Chien Hsu

IPC: H04B7/185

CPC classification number: H01Q25/007 ,  H01Q1/288 ,  H01Q19/17

Abstract: An antenna assembly includes a reflector having a focal plane, a first feed element located along the focal plane that illuminates the reflector to create a first contour beam at a first frequency and a second feed element located further from the reflector than the first feed element that illuminates the reflector to create a first spot beam at a second frequency, the second frequency being different than the first frequency.

Abstract translation: 天线组件包括具有焦平面的反射器，沿焦平面定位的第一馈送元件，其照亮反射器以产生第一频率处的第一轮廓波束和位于比第一馈送元件更靠近反射器的第二馈送元件， 照亮反射器以在第二频率处产生第一点波束，第二频率不同于第一频率。

公开(公告)号：US20110319406A1

公开(公告)日：2011-12-29

申请号：US12826338

申请日：2010-06-29

Applicant: Dae-Kee Kim ,  Yhun Yhong Sheen ,  Chenghua Jin ,  Chul-Yong Park ,  Domalapally Sreenu ,  Kota Sudhakar Rao ,  Maddeboina Krishnaiah ,  Vura Bala Subrahmanyam

Inventor： Dae-Kee Kim ,  Yhun Yhong Sheen ,  Chenghua Jin ,  Chul-Yong Park ,  Domalapally Sreenu ,  Kota Sudhakar Rao ,  Maddeboina Krishnaiah ,  Vura Bala Subrahmanyam

IPC: A61K31/444 ,  A61P11/00 ,  A61P35/04 ,  A61P25/00 ,  C07D471/04 ,  A61K31/5377

CPC classification number: C07D471/04

Abstract: This invention relates to 2-pyridyl substituted imidazoles which are inhibitors of the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in the treatment and prevention of a disease state mediated by these receptors.

Abstract translation: 本发明涉及作为转化生长因子抑制剂的2-吡啶基取代咪唑， （TGF-β）受体（ALK5）和/或激活素I型受体（ALK4），其制备方法及其在医学中的应用，特别是治疗和预防由这些受体介导的疾病状态。