公开(公告)号：US08377958B2

公开(公告)日：2013-02-19

申请号：US12830681

申请日：2010-07-06

Applicant: Ingrid Gunda Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj ,  Katherine Roby

Inventor： Ingrid Gunda Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj ,  Katherine Roby

IPC: A61K31/416 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/416 ,  A61K31/4162 ,  C07D231/56

Abstract: Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.

Abstract translation: 生育能力管理可以包括：向受试者施用一种或多种剂量的式I化合物，以降低受试者的生育能力。 生育能力管理还可以包括给予有效量的化合物以损害男性受试者的Sertoli细胞功能; 抑制受试者的精子发生; 减少受试者的睾丸重量; 减少女性受试者的卵巢重量; 减少女性受试者的血清孕酮; 影响女性卵巢卵泡功能; 导致受试者的可逆生育力。 为了返回生育力，该方法可以包括停止对受试者施用化合物以使受试者的生育力恢复。 该化合物可被用于不可逆地灭菌受试者。

公开(公告)号：US08332554B2

公开(公告)日：2012-12-11

申请号：US13172298

申请日：2011-06-29

Applicant: Baranitharan Subbiah ,  Sanjay Katabathuni ,  Shoby A. Cherian ,  Chi-Lie Wang ,  Maria Hu ,  Sudhakar Rao ,  Kap Soh ,  Scott W. Mitchell ,  Raymond Su ,  Lomberto P. Jimenez

Inventor： Baranitharan Subbiah ,  Sanjay Katabathuni ,  Shoby A. Cherian ,  Chi-Lie Wang ,  Maria Hu ,  Sudhakar Rao ,  Kap Soh ,  Scott W. Mitchell ,  Raymond Su ,  Lomberto P. Jimenez

IPC: G06F13/12 ,  G06F3/00 ,  G06F15/173 ,  G06F15/16

CPC classification number: H04L29/06068 ,  H04L29/06 ,  H04L29/12254 ,  H04L61/2038 ,  H04L69/08 ,  H04L69/324

Abstract: In one embodiment of a networking module, a first block receives a serial digital media signal, and provides a parallel digital media signal based on the serial digital media signal. A second block, operative with the first block, stores the parallel digital media signal in a corresponding slot in an outgoing frame, and sends the outgoing frame in response to receiving an incoming frame.

Abstract translation: 在网络模块的一个实施例中，第一块接收串行数字媒体信号，并且基于串行数字媒体信号提供并行数字媒体信号。 与第一块操作的第二块将并行数字媒体信号存储在输出帧中的相应时隙中，并且响应于接收到的帧而发送输出帧。

公开(公告)号：US20110319408A1

公开(公告)日：2011-12-29

申请号：US13168342

申请日：2011-06-24

Applicant: Dae-Kee Kim ,  Yhun Yhong Sheen ,  Chenghua Jin ,  Chul-Yong Park ,  Domalapally Sreenu ,  Kota Sudhakar Rao ,  Maddeboina Krishnaiah ,  Vura Bala Subrahmanyam

Inventor： Dae-Kee Kim ,  Yhun Yhong Sheen ,  Chenghua Jin ,  Chul-Yong Park ,  Domalapally Sreenu ,  Kota Sudhakar Rao ,  Maddeboina Krishnaiah ,  Vura Bala Subrahmanyam

IPC: A61K31/437 ,  A61P35/04 ,  A61P35/00 ,  A61P9/00 ,  A61P13/12 ,  A61P1/16 ,  A61P11/00 ,  A61P9/04 ,  A61P9/12 ,  A61P9/10 ,  A61P27/02 ,  A61P27/06 ,  A61P19/10 ,  A61P19/02 ,  A61P25/28 ,  A61P35/02 ,  A61K31/5377

CPC classification number: A61K31/437 ,  A61K31/5377

Abstract: This invention relates to use of inhibitors of the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4) in treating, preventing, or reducing fibrosis, cancer, and vascular injuries.

Abstract translation: 本发明涉及转化生长因子抑制剂的使用 - （TGF-β）受体（ALK5）和/或激活素I型受体（ALK4）在治疗，预防或减少纤维化，癌症和血管损伤中的作用。

公开(公告)号：US08067580B2

公开(公告)日：2011-11-29

申请号：US12863775

申请日：2009-02-05

Applicant: Sudhakar Rao Takkellapati ,  Joseph W. Farchaus

Inventor： Sudhakar Rao Takkellapati ,  Joseph W. Farchaus

IPC: C07H21/00

CPC classification number: C07H21/00 ,  C07K1/18 ,  C07K1/20 ,  C07K1/30 ,  C12N15/101

Abstract: The invention provides a method for the separation and purification of two or three cellular components selected from genomic DNA, RNA and proteins from a single biological sample. The method comprises generating an aqueous solution containing the cellular components by lysing cells with a lysis solution; contacting the aqueous solution with an ion exchanger for genomic DNA and RNA to bind to the ion exchanger; collecting the flow-through which contains unbound proteins; eluting RNA from the ion exchanger; and eluting DNA from the ion exchanger. For the purification of any two of the cellular components, one of the components is not collected. The invention also provides reagent kits for carrying out the methods.

Abstract translation: 本发明提供了从单个生物样品中分离和纯化选自基因组DNA，RNA和蛋白质的两种或三种细胞成分的方法。 该方法包括用裂解溶液裂解细胞产生含有细胞成分的水溶液; 使所述水溶液与用于基因组DNA和RNA的离子交换剂接触以结合到所述离子交换剂; 收集含有未结合蛋白质的流通液; 从离子交换器洗脱RNA; 并从离子交换器洗脱DNA。 对于任何两种细胞组分的纯化，其中一种组分不被收集。 本发明还提供了用于实施该方法的试剂盒。

公开(公告)号：US20110270064A1

公开(公告)日：2011-11-03

申请号：US13172382

申请日：2011-06-29

Applicant: Gordon Ian Rowlandson ,  David Thomas Peterson ,  Donald Eugene Brodnick ,  Robert Edward Henderson ,  Chepur Sudhakar Rao

Inventor： Gordon Ian Rowlandson ,  David Thomas Peterson ,  Donald Eugene Brodnick ,  Robert Edward Henderson ,  Chepur Sudhakar Rao

IPC: A61B5/04

CPC classification number: A61N1/0484 ,  A61N1/048 ,  A61N1/0488 ,  A61N1/0492

Abstract: A method and apparatus for the collection of physiological data from a patient is disclosed herein. An electrode assembly comprises an external label identifying an anatomical location and an electrode identifying circuitry that produces a signal indicative of the anatomical location to which the electrode assembly is to be attached. The electrode assembly transmits both the collected physiological signal and the identification signal to a data monitor for collection and processing physiological data.

Abstract translation: 本文公开了一种用于从患者收集生理数据的方法和装置。 电极组件包括识别解剖位置的外部标签和产生指示电极组件要附接到的解剖位置的信号的电极识别电路。 电极组件将收集的生理信号和识别信号传送到数据监视器，用于收集和处理生理数据。

公开(公告)号：US07996588B2

公开(公告)日：2011-08-09

申请号：US10449816

申请日：2003-05-30

Applicant: Baranitharan Subbiah ,  Sanjay Katabathuni ,  Shoby A. Cherian ,  Chi-Lie Wang ,  Maria Hu ,  Sudhakar Rao ,  Kap Soh ,  Scott W. Mitchell ,  Raymond Su ,  Lomberto P. Jimenez

Inventor： Baranitharan Subbiah ,  Sanjay Katabathuni ,  Shoby A. Cherian ,  Chi-Lie Wang ,  Maria Hu ,  Sudhakar Rao ,  Kap Soh ,  Scott W. Mitchell ,  Raymond Su ,  Lomberto P. Jimenez

IPC: G06F13/12 ,  G06F3/00 ,  G06F15/173 ,  G06F15/16

CPC classification number: H04L29/06068 ,  H04L29/06 ,  H04L29/12254 ,  H04L61/2038 ,  H04L69/08 ,  H04L69/324

Abstract: In one embodiment of a networking module, a first block receives a serial digital media signal, and provides a parallel digital media signal based on the serial digital media signal. A second block, operative with the first block, stores the parallel digital media signal in a corresponding slot in an outgoing frame, and sends the outgoing frame in response to receiving an incoming frame.

Abstract translation: 在网络模块的一个实施例中，第一块接收串行数字媒体信号，并且基于串行数字媒体信号提供并行数字媒体信号。 与第一块操作的第二块将并行数字媒体信号存储在输出帧中的相应时隙中，并且响应于接收到的帧而发送输出帧。

公开(公告)号：US20110152510A1

公开(公告)日：2011-06-23

申请号：US13059992

申请日：2009-08-21

Applicant: Sudhakar Rao Takkellapati ,  Manzer Khan ,  Rajesh Ambat

Inventor： Sudhakar Rao Takkellapati ,  Manzer Khan ,  Rajesh Ambat

IPC: C07H21/04

CPC classification number: C12N15/1006

Abstract: Provided is a novel two step chromatographic purification process (load and elute) for the isolation of genomic DNA. In this method the sample is loaded on the column and the genomic DNA product is eluted directly without any intermediate wash steps. This is accomplished by utilizing a restricted access resin (i.e., lid beads), which is easy to prepare and comprised of two layers with different properties with non-functional surfaces on the outer layer. The inner layer is modified with functional groups that act as ion-exchangers. Small molecules such as RNA and proteins can enter the inner part of the resin and larger genomic DNA molecules will pass through the resin. RNA and proteins are captured in the inner layer of the restricted access resin while genomic DNA is readily eluted in the flow-through.

Abstract translation: 提供了用于分离基因组DNA的新型两步色谱纯化方法（负载和洗脱）。 在该方法中，将样品加载到柱上，直接洗脱基因组DNA产物，无需任何中间洗涤步骤。 这通过利用容易制备的受限制的进入树脂（即，盖子珠）来实现，并且由外层上具有不同性质的两层与非功能性表面组成。 内层用作离子交换剂的官能团改性。 小分子如RNA和蛋白质可以进入树脂的内部，较大的基因组DNA分子将通过树脂。 RNA和蛋白质被捕获在限制性进入树脂的内层中，而基因组DNA在流通中容易洗脱。

公开(公告)号：US20090197911A1

公开(公告)日：2009-08-06

申请号：US12395521

申请日：2009-02-27

Applicant: Ingrid Gunda Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj ,  James P. Calvet

Inventor： Ingrid Gunda Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj ,  James P. Calvet

IPC: A61K31/4162 ,  A61K31/416 ,  A61P13/12

CPC classification number: C07D231/56 ,  C07D471/04

Abstract: Lonidamine derivatives can be useful in methods of treating, inhibiting, and/or preventing polycystic kidney disease (PKD). Accordingly, lonidamine derivatives can be administered in a therapeutically effective amount for inhibiting, and/or preventing polycystic kidney disease (PKD) in the subject. This can include administering a therapeutically effective amount of the lonidamine derivatives for inhibiting CFTR and/or Hsp90 or biological pathway thereof. Also, the method can include administering the lonidamine derivatives in a therapeutically effective amount for inhibiting ErbB2, Src, Raf-1, B-Raf, MEK, Cdk4, NKCC1, or combinations thereof. For example, the therapeutically effective amount of the lonidamine derivatives can be configured so as to provide a concentration in or adjacent to a kidney cell of about 0.25 uM or more or less.

Abstract translation: 罗丹明胺衍生物可用于治疗，抑制和/或预防多囊肾病（PKD）的方法。 因此，可以以治疗有效量的方式施用孤啡酸衍生物以抑制和/或预防受试者中的多囊肾病（PKD）。 这可以包括施用治疗有效量的用于抑制CFTR和/或Hsp90或其生物学途径的洋芋胺衍生物。 此外，该方法可以包括以治疗有效量施用用于抑制ErbB2，Src，Raf-1，B-Raf，MEK，Cdk4，NKCC1或其组合的兰酸胺衍生物。 例如，可以配置兰定胺衍生物的治疗有效量，以使其在肾细胞中或邻近肾细胞中的浓度为约0.25uM或更大或更小。

公开(公告)号：US20070018900A1

公开(公告)日：2007-01-25

申请号：US11362427

申请日：2006-02-23

Applicant: Sudhakar Rao ,  David Bressler

Inventor： Sudhakar Rao ,  David Bressler

IPC: H01Q13/00

CPC classification number: H01Q25/007 ,  H01Q5/45 ,  H01Q19/17

Abstract: An antenna system includes a reflector having a modified-paraboloid shape; and a multi-beam, multi-band feed array located at a focal point of the reflector so that the antenna system forms a multiple congruent beams that are contiguous. The system has a single reflector with non-frequency selective surface. The reflector is sized to produce a required beam size at K-band frequencies and is oversized at EHF-band frequencies. The synthesized reflector surface is moderately shaped and disproportionately broadens EHF-band and Ka-band beams compared to K-band beams. The synthesized reflector surface forms multiple beams each having a 0.5-degree diameter at K-band, Ka-band, and EHF band. The multi-beam, multi-band feed array includes a number of high-efficiency, multi-mode circular horns that operate in focused mode at K-band and defocused mode at Ka-band and EHF-band by employing “frequency-dependent” design for the horns.

Abstract translation: 天线系统包括具有改性抛物面形状的反射器; 以及位于反射器的焦点处的多光束，多波段馈电阵列，使得天线系统形成连续的多个一致的光束。 该系统具有一个具有非频率选择性表面的反射器。 反射器的尺寸被设计成在K波段频率处产生所需的波束尺寸，并且在EHF频带频率处变大。 合成的反射器表面适度成形，与K波段光束相比，EHF带和Ka波段光束不均衡地扩大。 合成的反射器表面形成多个光束，每个光束在K波段，Ka波段和EHF波段具有0.5度直径。 多波束多频馈电阵列包括多个高效多模环形喇叭，它们在Ka波段和EHF波段的K波段和散焦模式下以聚焦模式工作，采用“频率依赖” 喇叭设计。

公开(公告)号：US07109316B2

公开(公告)日：2006-09-19

申请号：US10226734

申请日：2002-08-23

Applicant: Shiv Kumar ,  Anup Sood ,  Sudhakar Rao ,  John Nelson

Inventor： Shiv Kumar ,  Anup Sood ,  Sudhakar Rao ,  John Nelson

IPC: C07H21/02 ,  C07H21/04 ,  C07H19/04 ,  C12Q1/68

CPC classification number: C07H19/04

Abstract: Oligonucleotide tagged nucleoside triphosphates, OTNTPs, which are substrates for polymerases and or terminal nucleotidyl transferases are provided as well as methods of making these OTNTPs. Further provided are OTNTPs with fluorescent dyes including energy transfer dyes, attached to the oligonucleotide chain, OTNTPs with unnatural bases incorporated in the oligonucleotide sequence and methods for incorporating these OTNTPs in DNA or RNA. Also provided are methods for using the oligonucleotides on OTNTPs for amplifying the oligo sequence on the OTNTP using an amplification method described above. Further provided are reactive bifunctional amidites, methods of making these compounds and methods for detecting single nucleotide polymorphisms using the above OTNTPs. Methods for detecting differential gene expression using the OTNTPs and methods of separating specifically modified DNA or RNA using the OTNTPs are also provided.

Abstract translation: 提供了寡聚核苷酸标记的核苷三磷酸酯，OTNTP，其是用于聚合酶和末端核苷酸转移酶的底物，以及制备这些OTNTP的方法。 还提供了含有荧光染料的OTNTP，其包括与寡核苷酸链连接的能量转移染料，掺入寡核苷酸序列中的非天然碱基的OTNTP以及将这些OTNTP引入DNA或RNA中的方法。 还提供了使用寡核苷酸在OTNTP上使用上述扩增方法在OTNTP上扩增寡核苷酸序列的方法。 还提供了反应性双官能脒，制备这些化合物的方法和使用上述OTNTP检测单核苷酸多态性的方法。 还提供了使用OTNTP检测差异基因表达的方法和使用OTNTP分离特异性修饰的DNA或RNA的方法。