公开(公告)号：US11410304B2

公开(公告)日：2022-08-09

申请号：US16900364

申请日：2020-06-12

Applicant: TOMOCUBE, INC.

Inventor： YongKeun Park ,  Donghun Ryu ,  Young Seo Kim ,  Kihyun Hong ,  Hyun-Seok Min

IPC: G06T7/00 ,  G06T7/11 ,  G06T7/73 ,  G01B9/021 ,  G01N21/45

Abstract: A non-label diagnosis apparatus for a hematologic malignancy may include a 3-D refractive index cell imaging unit configured to generate a 3-D refractive index slide image of a blood smear specimen by capturing a 3-D refractive index image in the form of the blood smear specimen in which blood (including a bone-marrow or other body fluids) of a patient has been smeared on a slide glass, an ROI detection unit configured to sample a suspected cell segment in the blood smear specimen based on the 3-D refractive index slide image and to determine, as ROI patches, cells determined as abnormal cells, and a diagnosis unit configured to determine a sub-classification of a cancer cell corresponding to each of the ROI patches using a cancer cell sub-classification determination model constructed based on a deep learning algorithm and to generate hematologic malignancy diagnosis results by gathering sub-classification results of the ROI patches.

公开(公告)号：US20220034646A1

公开(公告)日：2022-02-03

申请号：US17024303

申请日：2020-09-17

Applicant: Tomocube, Inc. ,  Korea Advanced Institute Of Science And Technology

Inventor： YongKeun PARK ,  Herve Jerome HUGONNET

IPC: G01B9/02 ,  G01B11/25 ,  G01B11/24

Abstract: Proposed are a three-dimensional (3D) optical tomography method and apparatus using a partially coherent light and a multi-illumination pattern. The 3D optical diffraction tomography method based on low coherence light and a multi-illumination pattern using a 3D optical diffraction tomography apparatus may include making light incident on a sample using a plurality of patterns, measuring, by an image measurement unit, different locations at different depth locations of the sample and measuring two-dimensional (2D) images of the sample, and reconstructing 3D refractive index information of the sample based on the different patterns and the 2D images obtained at the different depth locations.

公开(公告)号：US10976532B2

公开(公告)日：2021-04-13

申请号：US16308329

申请日：2017-06-09

Applicant: TOMOCUBE, INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： YongKeun Park

IPC: G02B21/00 ,  H04N13/365 ,  G02B21/26 ,  G02B21/36 ,  G06T3/40 ,  G06T11/00 ,  G02B26/08 ,  G02B21/06 ,  G01N21/17 ,  G01N21/45 ,  G01B9/02 ,  G02B6/32 ,  G02B6/35 ,  G01N21/64

Abstract: Presented are a structured illumination microscopy system using a digital micromirror device and a time-complex structured illumination, and an operation method therefor. A structured illumination microscopy system using a digital micromirror device and a time-complex structured illumination according to an embodiment may comprise: a light source; a digital micromirror device (DMD) for receiving light irradiated from the light source, implementing a time-complex structured illumination, and causing a controlled structured illumination to enter a sample; and a fluorescence image measurement unit for extracting a high-resolution 3D fluorescence image of the sample.

公开(公告)号：US20230410256A1

公开(公告)日：2023-12-21

申请号：US17818987

申请日：2022-08-11

Applicant: Tomocube, Inc.

Inventor： Hyunseok MIN ,  Dongmin RYU ,  Woonsoo LEE ,  Hansol YOON

IPC: G06T3/40 ,  G02B21/36

CPC classification number: G06T3/4053 ,  G06T3/4046 ,  G06T2200/04 ,  G06T3/4038 ,  G02B21/367 ,  G06T3/4023

Abstract: The present disclosure provides a system and method for improving image resolution of a three-dimensional (3-D) refractive index microscope based on an artificial intelligence (AI) technology. The present disclosure provides a technology for converting a low-resolution 3-D refractive index microscope image into a high-resolution 3-D refractive index image without physical machine conversion and re-photographing based on AI. That is, the present disclosure applies an AI technology, such as deep learning, in order to train an AI model with a physical correlation between a low-resolution 3-D refractive index microscope image and a high-resolution 3-D refractive index image of various samples, such as a cell and a tissue, and convert a low resolution image into a high resolution image without a change in a physical microscope based on the training. Furthermore, for the training of the AI model, the present disclosure uses physical characteristics of a refractive index image.

公开(公告)号：US11821834B2

公开(公告)日：2023-11-21

申请号：US17753479

申请日：2021-01-07

Applicant: TOMOCUBE, INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yongkeun Park ,  Seungwoo Shin

IPC: G01N21/23 ,  G01B9/02 ,  G01N21/41 ,  G01N21/45 ,  G01N21/17

CPC classification number: G01N21/23 ,  G01B9/02 ,  G01N21/41 ,  G01N21/45 ,  G01N2021/1787

Abstract: A method and apparatus for measuring a 3-D refractive index tensor are presented. The method for measuring a 3-D refractive index tensor according to an embodiment comprises the steps of: controlling incident light of a plane wave with respect to at least one angle and polarization; and measuring, in a polarization-dependent manner, the 2-D diffracted light of a specimen with respect to the incident light incident at the at least one angle and polarization, wherein the birefringence value and the 3-D structure of an alignment direction of molecules in the specimen having birefringence may be measured.

公开(公告)号：US20220404267A1

公开(公告)日：2022-12-22

申请号：US17753479

申请日：2021-01-07

Applicant: TOMOCUBE, INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： YongKeun PARK ,  Seungwoo SHIN

IPC: G01N21/23 ,  G01B9/02

Abstract: A method and apparatus for measuring a 3-D refractive index tensor are presented. The method for measuring a 3-D refractive index tensor according to an embodiment comprises the steps of: controlling incident light of a plane wave with respect to at least one angle and polarization; and measuring, in a polarization-dependent manner, the 2-D diffracted light of a specimen with respect to the incident light incident at the at least one angle and polarization, wherein the birefringence value and the 3-D structure of an alignment direction of molecules in the specimen having birefringence may be measured.

公开(公告)号：US11408725B2

公开(公告)日：2022-08-09

申请号：US17024303

申请日：2020-09-17

Applicant: Tomocube, Inc.

Inventor： YongKeun Park ,  Herve Jerome Hugonnet

IPC: G01B9/02 ,  G01B9/02091 ,  G01B11/24 ,  G01B11/25

Abstract: Proposed are a three-dimensional (3D) optical tomography method and apparatus using a partially coherent light and a multi-illumination pattern. The 3D optical diffraction tomography method based on low coherence light and a multi-illumination pattern using a 3D optical diffraction tomography apparatus may include making light incident on a sample using a plurality of patterns, measuring, by an image measurement unit, different locations at different depth locations of the sample and measuring two-dimensional (2D) images of the sample, and reconstructing 3D refractive index information of the sample based on the different patterns and the 2D images obtained at the different depth locations.

公开(公告)号：US20220156561A1

公开(公告)日：2022-05-19

申请号：US17431871

申请日：2019-09-27

Applicant: Tomocube, Inc. ,  Korea Advanced Institute of Science and Technology

Inventor： Kihyun Hong ,  Hyun-Seok Min ,  YongKeun Park ,  Geon Kim ,  Youngju Jo

IPC: G06N3/04 ,  G06T7/00

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying the predicted type of one or more microorganisms. In one aspect, a system comprises a phase-contrast microscope and a microorganism classification system. The phase-contrast microscope is configured to generate a three-dimensional quantitative phase image of one or more microorganisms. The microorganism classification system is configured to process the three-dimensional quantitative phase image using a neural network to generate a neural network output characterizing the microorganisms, and thereafter identify the predicted type of the microorganisms using the neural network output.

公开(公告)号：US10082662B2

公开(公告)日：2018-09-25

申请号：US15243265

申请日：2016-08-22

Applicant: Korea Advanced Institute of Science and Technology ,  Tomocube, Inc.

Inventor： YongKeun Park ,  Seungwoo Shin ,  Gwang Sik Park

IPC: G02B21/36 ,  G01N21/41 ,  G01N21/64 ,  G02B21/16 ,  G02B26/08 ,  G02B27/46 ,  G03H1/00 ,  G01N21/45 ,  G01N21/17

CPC classification number: G02B21/367 ,  G01N21/4133 ,  G01N21/45 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/1787 ,  G01N2201/0635 ,  G02B21/16 ,  G02B26/0833 ,  G02B27/46 ,  G03H1/0005 ,  G03H2001/005

Abstract: An ultra-high-speed 3D refractive index tomography and structured illumination microscopy system using a wavefront shaper and a method using the same are provided. A method of using an ultra-high-speed 3D refractive index tomography and structured illumination microscopy system that utilizes a wavefront shaper includes adjusting an irradiation angle of a plane wave incident on a sample by using the wavefront shaper, measuring a 2D optical field, which passes through the sample, based on the irradiation angle of the plane wave, and obtaining a 3D refractive index image from information of the measured 2D optical field by using an optical diffraction tomography or a filtered back projection algorithm.