公开(公告)号：US07288568B2

公开(公告)日：2007-10-30

申请号：US10395372

申请日：2003-03-24

申请人： Gordon W. Gribble ,  Tadashi Honda ,  Michael B. Sporn ,  Nanjoo Suh

发明人： Gordon W. Gribble ,  Tadashi Honda ,  Michael B. Sporn ,  Nanjoo Suh

IPC分类号： A61K31/275 ,  A61K31/19

CPC分类号： C07C255/47 ,  A61K31/19 ,  A61K31/275 ,  A61K31/277 ,  A61K31/35

摘要： Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.

摘要翻译： 用于化学预防性治疗诸如癌症，阿尔茨海默氏病，帕金森病，炎性肠病和多发性硬化症的化合物和方法。

公开(公告)号：US20070198638A1

公开(公告)日：2007-08-23

申请号：US11742630

申请日：2007-05-01

申请人： Katsuyuki Omura ,  Tadashi Honda ,  Soichiro Iga

发明人： Katsuyuki Omura ,  Tadashi Honda ,  Soichiro Iga

IPC分类号： G06F15/16

CPC分类号： G06F3/0481

摘要： An information sharing area, employed by all conferees for sharing information (object) or personal knowledge transmitted via information processors from conferees, and an editing display area, employed for editing a structure of the information (object) or shared knowledge, can be definitely distinguished from each other and displayed in a large display device commonly visible from all conferees. When the areas are displayed in the large display device and one of the objects displayed in the information sharing area is designated, the designated object is displayed at a desired location in the editing display area and can be edited through cooperative works by all conferees centering around a conference chairman.

摘要翻译： 所有与会者所采用的用于共享信息（对象）的信息共享区域以及来自与会者的信息处理器传送的个人知识以及用于编辑信息（对象）或共享知识的结构的编辑显示区域可以被明确区分 并显示在所有与会者通常可见的大型显示设备中。 当在大型显示装置中显示区域并且指定在信息共享区域中显示的对象之一时，指定对象被显示在编辑显示区域的期望位置，并且可以由所有与会者围绕的合作作品进行编辑 会议主席。

公开(公告)号：US5313863A

公开(公告)日：1994-05-24

申请号：US778863

申请日：1992-01-20

申请人： Kintaro Aihara ,  Tadashi Honda

发明人： Kintaro Aihara ,  Tadashi Honda

IPC分类号： B26D1/24 ,  B26D7/01 ,  B26D7/20 ,  B26F1/20 ,  B26D1/40 ,  B26D7/14

CPC分类号： B26F1/20 ,  B26D1/245 ,  B26D7/015 ,  B26D7/20 ,  B26D2007/202 ,  Y10T83/293 ,  Y10T83/323 ,  Y10T83/4838 ,  Y10T83/9314 ,  Y10T83/9408

摘要： A slit forming apparatus consists essentially of a rotary blade assembly, a rotary backing roller, and pressing projections. The rotary blade assembly contacts with or abuts against a strip-shaped material travelling over the rotary backing roller and then penetrates said material to form slits in it. The backing roller has banks for holding the strip-shaped material pressed by the rotary blade assembly, and also has grooves for receiving the blades of the rotary blade assembly when they penetrate the strip-shaped material. The pressing projections provided at opposite side ends of the assembly prevent the undersired movement of said material in the lateral or longitudinal direction. With this apparatus, substantially defect-free satisfactory slits are formed in the strip-shaped material.

摘要翻译： PCT No.PCT / JP91 / 00599 Sec。 371日期1992年1月20日 102（e）日期1992年1月20日PCT 1991年5月1日PCT PCT。 公开号WO91 / 17026 日期1991年11月14日。一种狭缝形成装置基本上由旋转刀片组件，旋转支承辊和按压突起组成。 旋转刀片组件与在旋转支承辊上行进的带状材料接触或抵接，然后穿过所述材料以在其中形成狭缝。 背衬辊具有用于保持由旋转刀片组件按压的条状材料的堤，并且还具有用于在旋转刀片组件穿透条形材料时接收旋转刀片组件的刀片的凹槽。 设置在组件的相对侧端部处的按压突起防止所述材料在横向或纵向方向上的较低的运动。 利用该装置，在带状材料中形成基本上无缺陷的令人满意的狭缝。

公开(公告)号：US11650777B2

公开(公告)日：2023-05-16

申请号：US17592469

申请日：2022-02-03

申请人： Tadashi Honda

发明人： Tadashi Honda

IPC分类号： G06F3/12

CPC分类号： G06F3/126 ,  G06F3/121 ,  G06F3/1206 ,  G06F3/1253 ,  G06F3/1285 ,  G06F3/12

摘要： A data conversion processing system, including: a queue server to accumulate a queue that specifies data conversion processing to a different data format; and circuitry to execute a converter that performs conversion of data specified by the queue, and a converter number adjustment module provided at a container as a user space on an operating system, wherein the converter number adjustment module, in a case that a number of queues equal to or larger than a threshold value are accumulated in the queue server, forms at least one virtual converter that performs data conversion processing the same as the data conversion processing of the converter at the container, and performs the data conversion processing corresponding to the number of queues equal to or larger than the threshold value.

公开(公告)号：US11200088B2

公开(公告)日：2021-12-14

申请号：US16793090

申请日：2020-02-18

申请人： Tadashi Honda

发明人： Tadashi Honda

IPC分类号： G06F9/46 ,  G06F9/48 ,  G06F9/50

摘要： An information processing system, an information processing method, and an information processing apparatus. The information processing system includes at least one memory configured to store a plurality of jobs in order, by type of processing to be executed and a plurality of processors assigned to a specific type of processing to be executed, processes a job assigned to other processor stored in the memory in substitution for the other processor based on a determination that the job of the assigned type of processing is not stored in the memory, and cancels substituting of the processing of the job assigned to the other processor according to a processing status of at least one of other processors.

公开(公告)号：US20180134654A1

公开(公告)日：2018-05-17

申请号：US15565846

申请日：2016-04-14

申请人： Tadashi Honda ,  Wei Li ,  Suqing Zheng ,  Albena Dinkova-Kostova

发明人： Tadashi Honda ,  Wei Li ,  Suqing Zheng ,  Albena Dinkova-Kostova

IPC分类号： C07C255/46 ,  C07C255/47 ,  A61K31/277 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07C255/46 ,  A61K31/277 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07C255/47 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2602/24 ,  C07C2603/18 ,  C07C2603/26

摘要： The present invention provides a compound having the structure: wherein X is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, cyano, aryl, heteroaryl, alkylaryl, alkylheteroaryl, alkenylaryl, alkenylheteroaryl, alkynylaryl, alkynylheteroaryl, alkoxy, alkenyloxy, alkynyloxy, aryloxy, heteroaryloxy, acyl, alkylhydroxy, alkylamino, alkenylamino, alkynylamino, amido, carboxyl, or carboxyl ester, or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with Y, Y is H or forms an unsubstituted or substituted cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, indane or tetralin with X, or forms an unsubstituted or substituted monocycle with Z; and Z is H or forms an unsubstituted or substituted monocycle with Y; wherein when X and Y are both H, then X is C2alkenyl or C2 alkynyl, and when Y is H forms a substituted cyclohexyl, cycloheptyl with X, the cyclohexyl is other than a trisubstituted cyclohexyl bearing CH3, i-Pr and (CH2)2CO2CH3 groups or CH3, i-Pr and (CH2)3NH2, or a salt or ester thereof.

公开(公告)号：US20180113792A1

公开(公告)日：2018-04-26

申请号：US15786716

申请日：2017-10-18

申请人： Masateru KUMAGAI ,  Tadashi HONDA ,  Kohichiroh NISHIKAWA ,  Tomoya AMIKURA

发明人： Masateru KUMAGAI ,  Tadashi HONDA ,  Kohichiroh NISHIKAWA ,  Tomoya AMIKURA

IPC分类号： G06F11/36 ,  G06F9/445 ,  G06F11/22 ,  G06F3/06

CPC分类号： G06F11/3664 ,  G06F3/0604 ,  G06F8/65 ,  G06F9/5005 ,  G06F11/2236 ,  G06F11/2273

摘要： An information processing system includes a first memory that stores information on a request for performing data processing associated with a type of the data processing, a second memory that stores information on a request for performing data processing for testing, and a plurality of circuitry that performs data processing according to the type of the data processing. The plurality of circuitry includes a first circuitry that operates in a normal mode and a second circuitry that operates in a test mode. The second circuitry starts up in the test mode to operate in the test mode if the first circuitry operates in the normal mode and transitions from the test mode to the normal mode according to a user request. In the normal mode, the circuitry acquires the information on the request for performing the data processing from the first memory and performs the data processing.

公开(公告)号：US20120220652A1

公开(公告)日：2012-08-30

申请号：US13359381

申请日：2012-01-26

申请人： Michael B. Sporn ,  Karen T. Liby ,  Gordon W. Gribble ,  Tadashi Honda ,  Robert M. Kral ,  Colin J. Meyer

发明人： Michael B. Sporn ,  Karen T. Liby ,  Gordon W. Gribble ,  Tadashi Honda ,  Robert M. Kral ,  Colin J. Meyer

IPC分类号： A61K31/277 ,  A61P13/12

CPC分类号： A61K31/4174 ,  A61K31/275 ,  A61K31/277 ,  A61K31/4164 ,  A61K2300/00

摘要： The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

摘要翻译： 本发明涉及使用合成三萜类化合物治疗和预防肾/肾病，胰岛素抵抗/糖尿病，脂肪肝疾病和/或内皮功能障碍/心血管疾病的方法，任选地与第二治疗或预防组合。

公开(公告)号：US20120101149A1

公开(公告)日：2012-04-26

申请号：US13127551

申请日：2009-10-29

申请人： Tadashi Honda ,  Michael B. Sporn ,  Karen T. Liby ,  Gordon W. Gribble ,  Robert M. Kral, JR. ,  Melean Visnick

发明人： Tadashi Honda ,  Michael B. Sporn ,  Karen T. Liby ,  Gordon W. Gribble ,  Robert M. Kral, JR. ,  Melean Visnick

IPC分类号： A61K31/277 ,  A61K48/00 ,  A61P35/00 ,  A61N5/00 ,  A61P3/06 ,  A61P9/12 ,  A61P25/00 ,  A61P13/12 ,  C07C255/47 ,  A61P29/00

CPC分类号： C07J41/0033 ,  C07J41/0055

摘要： This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment methods and methods of manufacture are also provided.

摘要翻译： 本发明的特征在于具有下式的桦木酸衍生物：其中变量在本文中定义。 本发明还提供了相关的化合物及其中间体，以及包含这些化合物的药物组合物，试剂盒和制品。 还提供了处理方法和制造方法。

公开(公告)号：US08067394B2

公开(公告)日：2011-11-29

申请号：US12777120

申请日：2010-05-10

申请人： Tadashi Honda ,  Chitra Sundararajan ,  Gordon W. Gribble ,  Michael B. Sporn ,  Karen T. Liby

发明人： Tadashi Honda ,  Chitra Sundararajan ,  Gordon W. Gribble ,  Michael B. Sporn ,  Karen T. Liby

IPC分类号： A61K31/695 ,  A61K31/277 ,  A61K31/4164 ,  A61K31/40 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07F7/0812 ,  C07C49/743 ,  C07C255/47 ,  C07C2603/26 ,  C07D207/337 ,  C07D209/08 ,  C07D233/64 ,  C07D295/145 ,  C07F7/081

摘要： This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferation of human myeloma cells, inhibit the induction of iNOS in cells stimulated with interferon-γ, induce heme oxygenase-1 (HO-1), induce CD11b expression—a leukemia differentiation marker, inhibit proliferation of leukemia cells, induce apoptosis in human lung cancer, and induce apoptosis in other cancerous cells. The TBEs of this invention are expected to be useful agents for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.

摘要翻译： 本发明描述了新型三环双烯衍生物（TBE），如TBE-31，TBE-34，TBE-45和水溶性TBE。 还公开了制备这些化合物的方法。 本发明人证明了这些新型TBE抑制人骨髓瘤细胞增殖的能力，抑制了用干扰素-γ刺激的细胞中诱导iNOS，诱导血红素加氧酶-1（HO-1），诱导CD11b表达 - 白血病分化标记， 抑制白血病细胞增殖，诱导人肺癌细胞凋亡，诱导其他癌细胞凋亡。 预期本发明的TBE可用于治疗和预防许多疾病，包括癌症，神经障碍，炎症和涉及氧化应激的病理学的有用试剂。