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11.发明授权Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权稠合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂公开(公告)号：US07655689B2
公开(公告)日：2010-02-02
申请号：US11338587
申请日：2006-03-20
Applicant: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
Inventor： Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC: C07D209/00 , A01N43/38
CPC classification number: C07D487/18
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
Abstract translation: 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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12.发明授权Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效稠合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂公开(公告)号：US07517904B2
公开(公告)日：2009-04-14
申请号：US11176810
申请日：2005-07-07
Applicant: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
Inventor： Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC: A61K31/407 , A61K31/34 , C07D491/08
CPC classification number: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
Abstract translation: 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：US06420403B1
公开(公告)日：2002-07-16
申请号：US09428609
申请日：1999-10-27
Applicant: Edwin J. Iwanowicz , T. G. Murali Dhar , Katerina Leftheris , Chunjian Liu , Toomas Mitt , Scott H. Watterson , Joel C. Barrish
Inventor： Edwin J. Iwanowicz , T. G. Murali Dhar , Katerina Leftheris , Chunjian Liu , Toomas Mitt , Scott H. Watterson , Joel C. Barrish
IPC: C07D26334
CPC classification number: C07D413/12 , C07D263/32
Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases.
Abstract translation: 本发明公开了IMPDH（肌苷-5'-单磷酸脱氢酶）的新型抑制剂的鉴定。 本文公开的化合物和药物组合物可用于治疗或预防IMPDH相关疾病，例如移植排斥反应和自身免疫性疾病。
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公开(公告)号：US6011029A
公开(公告)日：2000-01-04
申请号：US802329
申请日：1997-02-20
Applicant: Charles Z. Ding , Soong-Hoon Kim , John T. Hunt , Toomas Mitt , Rajeev Bhide , Katerina Leftheris
Inventor： Charles Z. Ding , Soong-Hoon Kim , John T. Hunt , Toomas Mitt , Rajeev Bhide , Katerina Leftheris
IPC: C07D401/14 , A61K31/00 , A61K31/35 , A61K31/4178 , A61K31/495 , A61K31/498 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/675 , A61P35/00 , A61P43/00 , C07D20060101 , C07D243/14 , C07D245/06 , C07D401/04 , C07D401/10 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/044 , C07D491/048 , C07D495/04 , C07D497/04 , C07D513/04 , C07F9/645 , C07D243/24
CPC classification number: C07D243/14 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D495/04
Abstract: The present invention comprises benzodiazepine compounds having farnesyl transferase inhibitory activity.
Abstract translation: 本发明包括具有法呢基转移酶抑制活性的苯并二氮杂类化合物。
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公开(公告)号：US5306837A
公开(公告)日：1994-04-26
申请号：US91389
申请日：1993-07-15
Applicant: Gregory S. Bisacchi , Toomas Mitt
Inventor： Gregory S. Bisacchi , Toomas Mitt
IPC: A61K31/52 , A61K31/522 , A61P31/12 , A61P31/22 , C07C235/40 , C07C243/08 , C07D473/00 , C07D473/18 , C07F7/18 , C07F7/10
CPC classification number: C07D473/00 , C07C235/40 , C07C243/08 , C07F7/1856 , C07C2101/04
Abstract: Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-6H-purin-6-one are described.
Abstract translation: 用于制备光学活性抗病毒化合物[1R-（1α，2β，3α）] - 2-氨基-9- [2,3-双（羟甲基）环丁基] -1,9-二氢 -6H-嘌呤-6-酮。
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Patent Agency Ranking
公开(公告)号：US07141578B2
公开(公告)日：2006-11-28
申请号：US10974049
申请日：2004-10-25
Applicant: Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
Inventor： Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC: A61K31/44 , A61K31/40 , C07D491/00 , C07D487/00
CPC classification number: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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公开(公告)号：US20060264459A1
公开(公告)日：2006-11-23
申请号：US11338587
申请日：2006-02-15
Applicant: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
Inventor： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC: A61K31/4709 , A61K31/407 , C07D491/02
CPC classification number: C07D487/18
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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18.发明授权Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof 失效稠合杂环琥珀酰亚胺化合物及其类似物的制备方法公开(公告)号：US06953679B2
公开(公告)日：2005-10-11
申请号：US10024878
申请日：2001-12-19
Applicant: Mark E. Salvati , Toomas Mitt , Ramesh N. Patel , Ronald L. Hanson , David Brzozowski , Animesh Goswami , Linda Nga Hoong Chu , Wen-sen Li , James H. Simpson , Michael J. Totleben , Weixuan He
Inventor： Mark E. Salvati , Toomas Mitt , Ramesh N. Patel , Ronald L. Hanson , David Brzozowski , Animesh Goswami , Linda Nga Hoong Chu , Wen-sen Li , James H. Simpson , Michael J. Totleben , Weixuan He
IPC: A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C12P17/10 , C12N1/00
CPC classification number: C07D487/18 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
Abstract translation: 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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19.发明申请METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF 失效熔融杂环化合物化合物的制备方法及其模拟物公开(公告)号：US20050119228A1
公开(公告)日：2005-06-02
申请号：US10024878
申请日：2001-12-19
Applicant: Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
Inventor： Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
IPC: A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC classification number: C07D487/18 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
Abstract translation: 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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公开(公告)号：US5198583A
公开(公告)日：1993-03-30
申请号：US770390
申请日：1991-10-03
Applicant: Gregory S. Bisacchi , Toomas Mitt
Inventor： Gregory S. Bisacchi , Toomas Mitt
IPC: C07C235/40 , C07C243/08 , C07D473/00 , C07F7/18
CPC classification number: C07D473/00 , C07C235/40 , C07C243/08 , C07F7/1856 , C07C2101/04
Abstract: The optically active antiviral compound [1R-(1.alpha., 2.beta., 3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)-cyclobutyl]-1,9-dihydro-6H-purin-6-one and novel intermediates useful in its preparation are described.
Abstract translation: 光学活性的抗病毒化合物[1R-（1α，2β，3α）] - 2-氨基-9- [2,3-双（羟甲基） - 环丁基] -1,9-二氢-6H-嘌呤-6 描述了一种可用于其制备的新型中间体。
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