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    Synthesis of asparagine-linked glycopeptides on a polymeric solid support
    2.
    发明授权
    Synthesis of asparagine-linked glycopeptides on a polymeric solid support 失效
    在聚合物固体支持物上合成天冬酰胺连接的糖肽

    公开(公告)号：US5679769A

    公开(公告)日：1997-10-21

    申请号：US477776

    申请日：1995-06-07

    Applicant: Samuel J. Danishefsky ,  Jacques Roberge ,  Xenia Beebe

    Inventor： Samuel J. Danishefsky ,  Jacques Roberge ,  Xenia Beebe

    IPC: A61K38/00 ,  A61K39/00 ,  C07H3/06 ,  C07H15/10 ,  C07H15/18 ,  C07H17/02 ,  C07K1/04 ,  C07K9/00 ,  C07K16/30 ,  C07K16/44 ,  A61K31/02

    CPC classification number: A61K39/0011 ,  C07H15/10 ,  C07H15/18 ,  C07H17/02 ,  C07H3/06 ,  C07K1/04 ,  C07K16/3015 ,  C07K16/44 ,  C07K9/005 ,  A61K38/00

    Abstract: The present invention provides a process for synthesizing a glycopeptide having the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each independently H, OH, OR.sup.1, NH.sub.2, NHCOR.sup.i, F, CH.sub.2 OH, CH.sub.2 OR.sup.i, or a substituted or unsubstituted linear or branched chain alkyl, arylalkyl or aryl group, where R.sup.i is H, CHO, CO.sub.2 R.sup.ii, a linear or branched chain alkyl, arylalkyl or aryl group, or an oligosaccharide moiety, etc., wherein R.sub.0 is H, a linear or branched chain alkyl, arylalkyl or aryl group; wherein R.sub.10 is a substituted or unsubstituted linear or branched chain acyl, arylacyl or aroyl group; wherein R.sub.11�x! represents X amino acid side-chains, and denotes position from the N-terminus, and R.sub.13�y! represents Y amino acid side-chains, and denotes position from the C-terminus, wherein a, b, c, h, i, j, r, s and t are each independently an integer between about 0 and about 3; wherein m and n are each independently an integer between about 0 and about 5; and wherein x, x'(N), y and y'(N) are each independently an integer between about 0 and,about 25; such glycopeptides being useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.

    Abstract translation: 本发明提供一种合成具有以下结构的糖肽的方法：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8各自独立地为H，OH，OR 1，NH 2，NHCOR 1 ，F，CH2OH，CH2ORi或取代或未取代的直链或支链烷基，芳烷基或芳基，其中R 1为H，CHO，CO 2 R 11，直链或支链烷基，芳烷基或芳基或寡糖部分等 其中R 0是H，直链或支链烷基，芳烷基或芳基; 其中R 10是取代或未取代的直链或支链酰基，芳基酰基或芳酰基; 其中R11 [x]表示X氨基酸侧链，表示从N-末端的位置，R13 [y]表示Y氨基酸侧链，表示C末端的位置，其中a，b，c ，h，i，j，r，s和t各自独立地为约0和约3之间的整数; 其中m和n各自独立地为约0和约5之间的整数; 并且其中x，x'（N），y和y'（N）各自独立地为约0和约25之间的整数; 这样的糖肽可用作用于在其辅助治疗中诱导人乳腺癌细胞的抗体的疫苗。

    Assembly for mounting a light fixture to a support structure
    3.
    发明授权
    Assembly for mounting a light fixture to a support structure 失效
    用于将灯具安装到支撑结构的组件

    公开(公告)号：US4636926A

    公开(公告)日：1987-01-13

    申请号：US705692

    申请日：1985-02-26

    Applicant: Jacques Roberge

    Inventor： Jacques Roberge

    IPC: F21V17/14 ,  F21V17/16 ,  F21V21/116 ,  F21V17/06

    CPC classification number: F21V17/164 ,  F21V17/14 ,  F21V21/116

    Abstract: A series of resilient blades are circumferentially disposed on an annular member to which a light fixture is attached and are adapted, through a rotational sliding motion, to come in overlapping interengagement with a second series of resilient blades disposed circumferentially on a base member mounted to the structure supporting the light fixture.

    Abstract translation: 一系列弹性叶片周向地设置在环形构件上，照明装置被附接到环形构件上，并且通过旋转滑动运动适应与第二系列弹性叶片重叠地相互配合，所述第二系列弹性叶片周向设置在安装到 结构支撑灯具。

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