公开(公告)号：US20210162682A1

公开(公告)日：2021-06-03

申请号：US17111439

申请日：2020-12-03

申请人： TransDerm, Inc.

发明人： Tycho J. SPEAKER ,  Manuel A. FLORES ,  Novejot K. SINGH ,  Abigail L. LAMBRETTI ,  Anna C. Henderson ,  Tyler A. STEWART ,  Andrea S. BURGON

IPC分类号： B29C67/00 ,  C08L29/04 ,  C08L5/00 ,  C08J5/18 ,  A61M37/00 ,  B29C69/00

摘要： Microstructure manufacturing apparatuses and methods are disclosed herein that enable the production of microstructures in an efficient, cost-effective manner that produces precise, high-quality microstructure products. In the manufacturing process for a microneedle array, for example, a template can be contacted against a surface of a continuous layer of a viscous polymer and separated from the surface to form a plurality of projections. The projections can then be solidified and later cut at a predetermined distance from the surface to form the microstructure.

公开(公告)号：US20210000455A1

公开(公告)日：2021-01-07

申请号：US17001610

申请日：2020-08-24

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/52

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US20190337197A1

公开(公告)日：2019-11-07

申请号：US16510815

申请日：2019-07-12

申请人： TransDerm, Inc.

发明人： Roger L. KASPAR ,  Tycho Speaker

IPC分类号： B29C41/02 ,  B81C1/00 ,  A61M37/00 ,  A61B5/00 ,  A61K9/00

摘要： An active agent can be administered transdermally to a patient by using a transdermal patch that has microneedles that are compositionally homogenous with a base layer. The transdermal patch can contain an active agent that can be delivered to a skin surface of a subject when the patch is applied.

公开(公告)号：US10751032B2

公开(公告)日：2020-08-25

申请号：US15939207

申请日：2018-03-28

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61B10/00 ,  A61B5/00 ,  G01N33/52

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US10695548B1

公开(公告)日：2020-06-30

申请号：US15668606

申请日：2017-08-03

申请人： Transderm Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00

摘要： The present invention is drawn to a low-cost “meso” device that is able to effectively deliver functional self-delivery siRNA to subject and inhibit expression of a gene in the subject as well as related methods. In particular, a method of transdermally delivering nucleic acid material to a subject is provided. The method includes adapting a motorized meso machine for delivery of nucleic acid material; introducing nucleic acid material into a chamber of the motorized meso machine; and contacting the motorized meso machine to a skin surface of a subject for a period of time sufficient to deliver the nucleic acid material into the skin surface of the subject.

公开(公告)号：US20180345627A1

公开(公告)日：2018-12-06

申请号：US15939207

申请日：2018-03-28

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： B32B9/02 ,  B32B27/30 ,  B32B27/34 ,  B32B27/36 ,  B32B27/40 ,  B32B33/00 ,  G01N33/52 ,  G01N21/81

摘要： A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.

公开(公告)号：US20180001070A1

公开(公告)日：2018-01-04

申请号：US15589915

申请日：2017-05-08

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K31/00 ,  A61K38/21 ,  A61L31/00 ,  A61B17/20 ,  C12N15/113 ,  A61K31/713 ,  A61K39/00

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61K31/00 ,  A61K31/713 ,  A61K38/21 ,  A61K39/00 ,  A61K2039/54 ,  A61L31/00 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61M2202/30 ,  A61M2205/583 ,  C12N15/113 ,  C12N2310/14

摘要： The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.

公开(公告)号：US20160263362A1

公开(公告)日：2016-09-15

申请号：US14788439

申请日：2015-06-30

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00 ,  A61K9/00 ,  C12N15/113 ,  A61K31/713 ,  A61K39/00 ,  A61B17/20 ,  A61K38/21

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61K31/00 ,  A61K31/713 ,  A61K38/21 ,  A61K39/00 ,  A61K2039/54 ,  A61L31/00 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61M2202/30 ,  A61M2205/583 ,  C12N15/113 ,  C12N2310/14

摘要： The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.

摘要翻译： 本发明提供了微针阵列及相关的系统和方法。 特别地，提供配置为递送活性剂（包括核酸和疫苗）的微针阵列。 还提供了接种疫苗和有效接种所必需的疫苗量的最小化的其它相关方法。

公开(公告)号：US20140046262A1

公开(公告)日：2014-02-13

申请号：US13758872

申请日：2013-02-04

申请人： Transderm, Inc.

发明人： Roger L. Kaspar ,  Tycho Speaker

IPC分类号： A61M37/00 ,  B29C41/02

CPC分类号： B29C41/02 ,  A61B5/685 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2037/0061 ,  B29C39/38 ,  B29C39/42 ,  B29C41/50 ,  B29C2059/023 ,  B29L2031/7544 ,  B81B2201/055 ,  B81C1/00111

摘要： The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.

摘要翻译： 本发明提供具有微针阵列的透皮递送装置及其制造和使用的方法。 在一个实施方案中，提供透皮递送装置。 透皮递送装置包括具有从其表面之一突出的微针的聚合物层。 微针与聚合物基层的组成是均匀的。

公开(公告)号：US20140037768A1

公开(公告)日：2014-02-06

申请号：US13932928

申请日：2013-07-01

申请人： Transderm, Inc.

发明人： Roger Louis Kaspar ,  Robyn Patricia Hickerson

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C12N2310/14

摘要： A method for keratin hyperproliferation disorders such as corns, calluses, or keratosis pilaris (KP) by administering to a subject experiencing the disorder a therapeutically effective amount of an RNA sequence which inhibits expression of a gene encoding for a keratin selected from the group consisting of K6a, K6b, K16, K17, and combinations thereof.

摘要翻译： 一种角蛋白过度增生病症如玉米，愈伤组织或角化病（KP）的方法，通过向经历病症的受试者施用治疗有效量的抑制编码选自下组的角蛋白基因表达的RNA序列： K6a，K6b，K16，K17及其组合。