公开(公告)号：US20050070022A1

公开(公告)日：2005-03-31

申请号：US10675763

申请日：2003-09-30

Applicant: Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

Inventor： Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

IPC: G01N33/00

CPC classification number: H01J49/0009 ,  C10L1/1857 ,  Y10T436/13 ,  Y10T436/173845 ,  Y10T436/200833 ,  Y10T436/24 ,  Y10T436/25125

Abstract: Method of identification and quantitative analysis of aldehyde(s) and/or ketone(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said aldehyde(s) and/or ketone(s) with a stable isotope labeled reagent, and is added to a sample containing said aldehyde(s) and/or ketone(s). Said aldehyde(s) and/or ketone(s) in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said aldehyde(s) and/or ketone(s) are made from a plot of ion ratio of said converted aldehyde and/or ketone to said internal standard versus aldehyde and/or ketone concentration.

Abstract translation: 提供了使用稳定同位素标记的内标通过质谱鉴定和定量分析样品中的醛和/或酮的方法。 所述内标是通过将所述醛和/或酮的真实样品与稳定同位素标记的试剂反应制备的，并加入到含有所述醛和/或酮的样品中， 。 然后使用非标记试剂将所述样品中的所述醛和/或酮定量地转化为具有相同结构的化合物，除了稳定的同位素原子，如所述内标的那样。 然后提取所述样品，并通过质谱法分析提取物。 所述醛和/或酮的鉴定和定量由所述转化的醛和/或酮与所述内标的离子比对醛和/或酮浓度的曲线图来制备。

公开(公告)号：US20050014279A1

公开(公告)日：2005-01-20

申请号：US10619709

申请日：2003-07-14

Applicant: Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

Inventor： Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

IPC: A61M36/14 ,  G01N33/00 ,  G01N33/487

CPC classification number: G01N33/6848 ,  H01J49/00 ,  Y10T436/17 ,  Y10T436/173845

Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

Abstract translation: 提供了使用稳定同位素标记的内标通过质谱鉴定和定量分析样品中的一级或二级胺的方法。 所述内标是通过将所述胺的真实样品与稳定同位素标记的试剂反应制备的，并加入含有所述胺的样品中。 然后使用非标记试剂将所述样品中的所述胺定量转化为具有相同结构的化合物，除了稳定的同位素原子，如所述内标的那样。 然后提取所述样品，并通过质谱法分析提取物。 所述胺的鉴定和定量由所述转化的胺与所述内标的离子比对胺浓度的曲线图来制备。

公开(公告)号：USD1062934S1

公开(公告)日：2025-02-18

申请号：US29931682

申请日：2024-03-08

Applicant: Trinh Nguyen Khanh Le

Designer： Trinh Nguyen Khanh Le

公开(公告)号：US20090245218A1

公开(公告)日：2009-10-01

申请号：US12079977

申请日：2008-03-31

Applicant: Trinh Nguyen

Inventor： Trinh Nguyen

IPC: H04Q7/28

CPC classification number: H04Q3/66 ,  H04Q2213/13034 ,  H04Q2213/13056 ,  H04Q2213/13098 ,  H04Q2213/13141 ,  H04Q2213/13144 ,  H04Q2213/13146 ,  H04Q2213/13164 ,  H04Q2213/13166 ,  H04Q2213/13196 ,  H04Q2213/13332 ,  H04Q2213/13344 ,  H04Q2213/13353 ,  H04Q2213/13389

Abstract: The present invention provides for giving preference to a specific media gateway in the selection of the next circuit so that in a multi-media-gateway soft-switch where a call may take any of many possible paths, an outgoing circuit on the same media-gateway as the incoming circuit is preferably selected, so if one is available, the need for using more bearer ports on media gateways to bridge the two sides is eliminated. Instead of interconnection, the same facilities can be provisioned to the bearer interface between the soft-switch and the rest of the network. This invention maximizes the bearer capacity of a distributed media gateway for external network access.

Abstract translation: 本发明提供了在选择下一个电路时给予特定媒体网关的优先权，使得在多媒体网关软交换机中，呼叫可以采用许多可能的路径中的任何一个，同一媒体上的输出电路， 作为输入电路的网关优选地被选择，因此如果可用，则消除在媒体网关上使用更多承载端口来桥接两侧的需要。 代替互连，可以将相同的设施提供给软交换机和网络的其余部分之间的承载接口。 本发明使用于外部网络接入的分布式媒体网关的承载能力最大化。

公开(公告)号：US20070010025A1

公开(公告)日：2007-01-11

申请号：US11486417

申请日：2006-07-12

Applicant: Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

Inventor： Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

IPC: G01N33/00

CPC classification number: G01N33/6848 ,  H01J49/00 ,  Y10T436/17 ,  Y10T436/173845

Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

公开(公告)号：US20050079544A1

公开(公告)日：2005-04-14

申请号：US10684249

申请日：2003-10-13

Applicant: Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

Inventor： Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

IPC: C12Q1/26 ,  C40B70/00 ,  G01N33/53 ,  G01N33/543

CPC classification number: C12Q1/26 ,  B01J2219/00581 ,  B01J2219/00702 ,  C40B70/00 ,  G01N2333/90245

Abstract: Method of automated metabolic stability analysis of library of compounds by mass spectrometry using stable isotope labeled internal standards is provided. Said internal standards are prepared in situ by reaction of an authentic sample of said library compounds with a stable isotope labeled reagent. In an automated fashion, cytochrome P450 enzyme systems are added to said library compounds; said reactions are terminated after certain periods of time by addition of an organic solvent containing equal amounts of said labeled internal standards; said terminated enzyme reactions are treated with a non-labeled version of said stable isotope labeled reagent to convert remaining library compounds to compounds of identical structures, except the labeled atoms, as those of said labeled internal standards; said conversion reactions are extracted and the extracts are analyzed by isotope dilution mass spectrometry to determine the percentage of library compounds remaining after enzyme reactions.

Abstract translation: 提供了使用稳定同位素标记的内部标准通过质谱法对化合物文库进行自动化代谢稳定性分析的方法。 所述内标是通过所述文库化合物的真实样品与稳定同位素标记的试剂的反应原位制备的。 以自动化方式，将细胞色素P450酶系统加入到所述文库化合物中; 所述反应通过加入含有等量的所述标记的内标物的有机溶剂在一段时间后终止; 所述终止的酶反应用非标记形式的所述稳定同位素标记的试剂处理，以将剩余的文库化合物转化成除了标记的原子以外的相同结构的化合物，如所述标记的内标物的化合物; 提取所述转化反应，并通过同位素稀释质谱法分析提取物，以确定酶反应后残留的文库化合物的百分比。