公开(公告)号：US20230151109A1

公开(公告)日：2023-05-18

申请号：US17929031

申请日：2020-02-13

申请人： UCB BIOPHARMA SRL

发明人： David Alan COOK ,  Helen Margaret FINNEY ,  Stephen Edward RAPECKI

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2896 ,  C07K16/2878 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/75

摘要： The present invention relates to multispecific antibodies against a novel targets' combination of CD9 and another antigen, and their use in the treatment of cancer and infectious diseases.

公开(公告)号：US20230096030A1

公开(公告)日：2023-03-30

申请号：US17929029

申请日：2020-02-13

申请人： UCB BIOPHARMA SRL

发明人： David Alan COOK ,  Helen Margaret FINNEY ,  Stephen Edward RAPECKI

IPC分类号： C07K16/28

摘要： The present invention relates to multispecific antibodies against a novel targets' combination of CD7 and CD9, and their use in the treatment of cancer and infectious diseases.

公开(公告)号：US20230087378A1

公开(公告)日：2023-03-23

申请号：US17786996

申请日：2020-12-18

申请人： UCB BIOPHARMA SRL

发明人： Adnan Rahman Khan ,  Sam Philip Heywood ,  David Paul Humphreys ,  Daniel John Lightwood ,  Emma Dave ,  Emily Mary Cairistine Barry ,  Sarah Jayne Stanyon

IPC分类号： C07K16/24 ,  A61P37/08

摘要： The present invention relates to a multi-specific antibody having specificity for human IL-13, human IL-17A and/or human IL-17F. The invention further relates to methods for producing the multi-specific antibody and to its therapeutic use for the treatment of atopic dermatitis and other diseases.

公开(公告)号：US20230075753A1

公开(公告)日：2023-03-09

申请号：US17759986

申请日：2021-02-01

申请人： UCB BIOPHARMA SRL

发明人： Neesha DEDI ,  Peter Charles ELLIOTT ,  Seppe Frans Roman LEYSEN ,  Sean MASON ,  David James MCMILLAN ,  Gillian Claire NESS ,  Niccolo PENGO ,  Martin Anthony REDHEAD ,  Alison TURNER ,  Kerry Louise TYSON

IPC分类号： C07K16/40 ,  C12N15/63 ,  A61P17/00

摘要： The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory antibodies binding KLK5 and their use in the treatment of Netherton disease, atopic dermatitis and cancer.

公开(公告)号：US20230065921A1

公开(公告)日：2023-03-02

申请号：US17821688

申请日：2022-08-23

申请人： UCB Biopharma SRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC分类号： C07K16/28 ,  A01K67/027

摘要： The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

公开(公告)号：US11472879B2

公开(公告)日：2022-10-18

申请号：US16778523

申请日：2020-01-31

申请人： UCB Biopharma SRL

发明人： Helene Margaret Finney ,  Stephen Edward Rapecki ,  Kerry Louise Tyson ,  Michael John Wright

IPC分类号： C07K16/28 ,  A01K67/027 ,  A61K39/00

摘要： The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

公开(公告)号：US11458124B2

公开(公告)日：2022-10-04

申请号：US17058973

申请日：2019-07-08

申请人： UCB Biopharma SRL

发明人： Gareth Neil Brace ,  Daniel Christopher Brookings ,  Gregory Foulkes ,  Fabien Claude Lecomte

IPC分类号： C07D405/14 ,  A61K31/422 ,  A61K31/352 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  C07D311/96 ,  C07D405/12 ,  C07D413/12 ,  C07D491/107 ,  C07D491/20 ,  C07D493/10

摘要： A series of substituted spirocyclic indane derivatives of Formula (I), and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20220280887A1

公开(公告)日：2022-09-08

申请号：US17631897

申请日：2020-07-30

申请人： UCB BIOPHARMA SRL

发明人： NEIL ALAN WATSON ,  CURTIS WILLIAM PHIPPEN

IPC分类号： B01D15/38 ,  C07K1/22 ,  C07K16/12 ,  C07K1/18 ,  C07K16/06

摘要： The invention relates to the field of manufacturing recombinant antibody molecules. In particular, methods of purifying such recombinant antibody molecules are provided wherein imidazole or an imidazole-analogue is added during the elution of the recombinant antibody molecule from an affinity chromatography resin, such as a protein-A-based resin.

公开(公告)号：US20220251064A1

公开(公告)日：2022-08-11

申请号：US17621871

申请日：2020-06-29

申请人： UCB Biopharma SRL

发明人： Anne Valade

IPC分类号： C07D401/06

摘要： The present invention relates to compounds according to formula (I), which are a positive allosteric modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US11407835B2

公开(公告)日：2022-08-09

申请号：US16300522

申请日：2017-05-11

申请人： UCB BIOPHARMA SRL

发明人： Andrew Jeffrey Yates ,  Jan Ivo Massant

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K9/19 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

摘要： The present invention relates to pharmaceutical compositions comprising an antibody or a fragment thereof suitable for freeze-drying (i.e. lyophilizing). The pharmaceutical compositions, which comprise an antibody or an antigen-binding fragment thereof; from 1% to 20% w/v sucrose; an amino acid or a mixture of amino acids; and surfactant, are provided as pharmaceutical compositions for freeze-drying; as freeze-dried (i.e. lyophilized) compositions which can be reconstituted into a solvent at the time of use or as reconstituted liquid formulations ready for administration.