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公开(公告)号：US20170119945A1
公开(公告)日：2017-05-04
申请号：US15317763
申请日：2015-06-10
发明人： Till NEUMANN
CPC分类号： A61M1/1031 , A61M1/1008 , A61M1/101 , A61M1/1024 , A61M1/1029 , A61M1/1032 , A61M1/1036 , A61M1/1086 , A61M1/122 , A61M1/125 , A61M1/127 , A61M2205/0266 , A61M2205/8243
摘要： The disclosure relates to a pump for implantation into a vessel or a heart, with the pump being introduced in a first state into the vessel or heart in order then be functionally changed over to a second state in the vessel or in the heart, having a drive part and a delivery part, where the drive part is not functional in the first state and becomes functional as a result of the changeover to the second state, wherein the drive part has an electric motor, where the electric motor is embodied as a wet rotor, and where, in the first state, the rotor of the electric motor and the stator of the electric motor are arranged so as to be separate from one another, and where the rotor of the electric motor is moved into the stator of the electric motor in the second state, where the rotor can drive the delivery part in the second state.
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公开(公告)号：US20170020998A1
公开(公告)日：2017-01-26
申请号：US15286327
申请日：2016-10-05
申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE , UNIVERSITAET DUISBURG-ESSEN
CPC分类号： A61K38/50 , A61K9/0014 , A61K9/0019 , A61K9/0073 , A61K9/12 , A61K45/06 , C12Y305/01023
摘要： The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
摘要翻译： 本发明涉及用于治疗或预防患有囊性纤维化，COPD和/或开放性伤口的受试者的病原体感染的方法。 该方法包括选择具有囊性纤维化，COPD和/或开放性伤口的受试者，并在有效减少神经酰胺的病症和治疗或预防病原体感染的条件下向所选受试者施用神经酰胺酶。 该方法还涉及使用神经酰胺酶与其他药物组合以减少感染，减少神经酰胺，或改善囊性纤维化，COPD和/或开放性伤口患者的肺功能。
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公开(公告)号：US10962757B2
公开(公告)日：2021-03-30
申请号：US16320777
申请日：2017-07-13
发明人： Matthias Gunzer , Reinhard Viga , Sven Olfen , Anton Grabmaier , Marc Schuster
摘要： A system for the simultaneous videographic or photographic acquisition of images, in particular of samples in a plurality of sample chambers of a sample plate, preferably a microtiter plate, includes an array of microscopes having mutually parallel optical axes, wherein each microscope includes an imaging chip and an objective. The imaging chips are attached to a carrier board as an array of columns and rows. An electronics unit for processing image data for all the microscopes is associated with the carrier board.
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公开(公告)号：US10207038B2
公开(公告)日：2019-02-19
申请号：US15317763
申请日：2015-06-10
发明人： Till Neumann
摘要： The disclosure relates to a pump for implantation into a vessel or a heart, with the pump being introduced in a first state into the vessel or heart in order then be functionally changed over to a second state in the vessel or in the heart, having a drive part and a delivery part, where the drive part is not functional in the first state and becomes functional as a result of the changeover to the second state, wherein the drive part has an electric motor, where the electric motor is embodied as a wet rotor, and where, in the first state, the rotor of the electric motor and the stator of the electric motor are arranged so as to be separate from one another, and where the rotor of the electric motor is moved into the stator of the electric motor in the second state, where the rotor can drive the delivery part in the second state.
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公开(公告)号：US10106608B2
公开(公告)日：2018-10-23
申请号：US15221612
申请日：2016-07-28
申请人： UNIVERSITAET DUISBURG-ESSEN , Karl Sebastian Lang , Bernhard Singer , Vishal Khairnar , Vikas Duhan
IPC分类号： G01N33/53 , C07K16/00 , C07H21/04 , C07K16/28 , A61K38/17 , A61K39/095 , A61K39/102 , A61K39/104 , C12N5/0783
摘要： An anti-CEACAM1 antibody includes at least one antibody heavy chain (VH) domain having antigen binding sites CDR1H, CDR2H and CDR3H, and at least one antibody light chain (VL) domain having antigen binding sites CDR1L, CDR2L and CDR3L. The antigen binding site CDR2H has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).
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公开(公告)号：US09492514B2
公开(公告)日：2016-11-15
申请号：US14404881
申请日：2013-05-31
申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE , UNIVERSITAET DUISBURG-ESSEN
CPC分类号： A61K38/50 , A61K9/0014 , A61K9/0019 , A61K9/0073 , A61K9/12 , A61K45/06 , C12Y305/01023
摘要： The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
摘要翻译： 本发明涉及用于治疗或预防患有囊性纤维化，COPD和/或开放性伤口的受试者的病原体感染的方法。 该方法包括选择具有囊性纤维化，COPD和/或开放性伤口的受试者，并在有效减少神经酰胺的病症和治疗或预防病原体感染的条件下向所选受试者施用神经酰胺酶。 该方法还涉及使用神经酰胺酶与其他药物组合以减少感染，减少神经酰胺，或改善囊性纤维化，COPD和/或开放性伤口患者的肺功能。
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公开(公告)号：US20230174606A1
公开(公告)日：2023-06-08
申请号：US17920055
申请日：2021-04-20
发明人： Ulf DITTMER , Kathrin SUTTER , Mirko TRILLING
摘要： The present disclosure relates to recombinant interferon alpha 2 (IFNa2) mutants and variants as well as fragments thereof, nucleic acids encoding them, pharmaceutical compositions containing them, and methods of use thereof.
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公开(公告)号：US20230131339A1
公开(公告)日：2023-04-27
申请号：US17801684
申请日：2021-02-26
申请人： Universitaet Ulm , Baden-Wuerttemberg Stiftung gGmbH , German University in Cairo , Aarhus University , Universitaet Duisburg-Essen
发明人： Jan MUENCH , Frank KIRCHHOFF , Mirja HARMS , Ashraf H. ABADI , Monika Maged Wadi HABIB , Alexander ZELIKIN , Sheiliza CARMALI , Elsa SANCHEZ GARCIA , Pandian SOKKAR
摘要： A peptide derivative selected from a list of peptide derivatives with a sequence derived from human serum albumin fragment EPI-X4 is provided, which binds to CXCR4 with about 1000-fold stronger efficiency than EPI-X4. The peptide derivatives comprise length variants as well as modifications by length variants, D-amino acids, coupling of fatty acids, cholesterol or polymers, acetyl substitutions of amino groups, amination of carboxyl groups. Further provided are pharmaceutical compositions of the peptide derivative.
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公开(公告)号：US11322672B2
公开(公告)日：2022-05-03
申请号：US15583066
申请日：2017-05-01
申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V. , Universitaet Duisburg-Essen
发明人： Erik Verheyen , Tobias Kleinfeld , Dirk Weiler , Holger Vogt
摘要： Described is an integrated vertical structure for infrared sensors, Peltier cooling, and thermoelectric generator applications consisting of a thermally insulating layer which is kept at a distance to a substrate by at least two spacers. In addition, the spacers have conductor structures which serve as thermoelectric elements.
A method realizes manufacturing the integrated thermoelectric structure, a method realizes the operation of the integrated thermoelectric structure as a detector, a further method realizes the operation of the integrated thermoelectric structure as a thermoelectric generator, and a method realizes the operation of the integrated thermoelectric structure as a thermoelectric Peltier element.-
20.发明申请公开(公告)号：US20190162944A1
公开(公告)日：2019-05-30
申请号：US16320777
申请日：2017-07-13
发明人： Matthias GUNZER , Reinhard VIGA , Sven OLFEN , Anton GRABMAIER , Marc SCHUSTER
摘要： A system for the simultaneous videographic or photographic acquisition of images, in particular of samples in a plurality of sample chambers of a sample plate, preferably a microtiter plate, includes an array of microscopes having mutually parallel optical axes, wherein each microscope includes an imaging chip and an objective. The imaging chips are attached to a carrier board as an array of columns and rows. An electronics unit for processing image data for all the microscopes is associated with the carrier board.
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