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公开(公告)号：US10035112B2
公开(公告)日：2018-07-31
申请号：US14089393
申请日：2013-11-25
发明人： Stephan Barcikowski , Marcus Lau
IPC分类号： B01F3/12 , B22F1/00 , B22F9/04 , B23K26/00 , B82Y30/00 , A61K33/24 , A61K49/00 , G01N33/58 , G01N33/553
CPC分类号： B01F3/1235 , A61K33/24 , A61K49/0065 , B22F1/0018 , B22F1/0022 , B22F9/04 , B23K26/352 , B82Y30/00 , G01N33/553 , G01N33/587
摘要： The invention provides a process for the production of nanoparticles as well as a device that is disposed for the production of the nanoparticles. The process is especially characterized in that the nanoparticles are pure, especially free from organic carbon compounds, preferably carbon-free, and are obtained continuously. The nanoparticles which are obtainable by the process of the invention are characterized in that they are present without an organic ligand in suspension and are especially preferred stable as a suspension against agglomeration, wherein the medium having the particles suspended therein is free from organic carbon compounds, especially carbon-free.
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公开(公告)号：US10022697B2
公开(公告)日：2018-07-17
申请号：US14875310
申请日：2015-10-05
摘要： An arc reactor and a process for the production of nanoparticles are disclosed. The reactor has a crucible in a gas-tight housing having a carrier gas inlet and a spaced-apart carrier gas outlet. The carrier gas inlet is directed to the side of the crucible opposite the crucible opening. The inlet can be disposed below the crucible and directed to the side of the crucible opposite the crucible opening. The carrier gas outlet is disposed above the crucible and exits the housing above the crucible. The carrier gas outlet is formed by a hood disposed at a distance above the crucible, which is separated from the crucible and formed by an exhaust pipe that connects the hood to the carrier gas outlet of the housing. The reactor housing has at least one inlet for cooling gas. This can be directed at an interstice formed between the crucible and the hood.
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公开(公告)号：US20170317260A1
公开(公告)日：2017-11-02
申请号：US15583066
申请日：2017-05-01
申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V. , Universitaet Duisburg-Essen
发明人： Erik VERHEYEN , Tobias KLEINFELD , Dirk WEILER , Holger VOGT
摘要： Described is an integrated vertical structure for infrared sensors, Peltier cooling, and thermoelectric generator applications consisting of a thermally insulating layer which is kept at a distance to a substrate by at least two spacers. In addition, the spacers have conductor structures which serve as thermoelectric elements.A method realizes manufacturing the integrated thermoelectric structure, a method realizes the operation of the integrated thermoelectric structure as a detector, a further method realizes the operation of the integrated thermoelectric structure as a thermoelectric generator, and a method realizes the operation of the integrated thermoelectric structure as a thermoelectric Peltier element.
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公开(公告)号：US10987413B2
公开(公告)日：2021-04-27
申请号：US15826879
申请日：2017-11-30
发明人： Dirk Schadendorf , Annette Paschen , Silke Lübcke , Martina Fatho , Daniela Eberts , Hakim Echchannaoui , Volker Lennerz , Catherine Woelfel , Thomas Woelfel
IPC分类号： A61K39/00 , C07K14/725 , C07K14/715 , C12N9/90 , G01N33/569 , A61K35/17 , G01N33/50 , A61K38/00
摘要： The present invention relates to novel tumor-associated antigens, which elicit independently from a presentation via MHC a CD8-positive T-cell response. GM-CSF-Receptor alpha chain (CSF2RA) and Tyrosinase-related protein 2 (TRP-2) were found to be targets of CD8-positive T-cell clones which could detect the proteins on the surface of HLA I negative melanoma cells. Thus, the invention provides proteins, protein fragments and polypeptides of the novel antigens for use in medicine, for example for the treatment, diagnosis and prevention of a tumor disease. Furthermore provided are nucleic acids expressing the antigens of the invention, binding agents specific for the antigens of the invention, such as T-cell receptor chains and isolated T cells which are reactive against the antigens of the invention or which express the T-cell receptors of the invention. The invention further pertains to pharmaceutical compositions, especially vaccine compositions, comprising the antigens, nucleic acids, binding agents or T cells in accordance with the invention, and methods for the generation of T cells, which are specifically reactive to the antigens of the invention in an MHC-independent manner.
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公开(公告)号：US20180348104A1
公开(公告)日：2018-12-06
申请号：US15779062
申请日：2016-11-30
发明人： Anika KLINGBERG
IPC分类号： G01N1/34 , G01N33/483
CPC分类号： G01N1/30
摘要： The invention provides a method for optical clearing of biological samples utilizing a composition comprising a cinnamate ester. The invention further provides a kit suitable for performing said method and the use of said composition for optical clearing of biological samples.
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公开(公告)号：US09877989B2
公开(公告)日：2018-01-30
申请号：US14414843
申请日：2013-07-18
发明人： Dietrich Wilhelm Beelen , Thorsten Doeppner , Ursula Felderhoff-Mueser , Bernd Giebel , Dirk Hermann , Peter Horn , Matthias Keller , Lambros Kordelas , Anna-Kristin Ludwig , Vera Rebmann
CPC分类号： A61K35/28 , A61K9/0019 , A61K38/17 , A61K38/1709 , A61K38/1841 , A61K38/19 , A61K38/2053 , A61K38/2066 , A61K38/217
摘要： The present invention relates to the use of exosome-preparations derived from neonatal or adult tissue-derived mesenchymal stem-cells (MSCs) for the prevention or for therapy of inflammatory conditions, such as, for example, pre- and postnatally acquired damages of the brain (i.e. neuronal damages) or in complications following stem cell transplantation (“graft vs host-disease”, GvHD).
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公开(公告)号：US20170051058A1
公开(公告)日：2017-02-23
申请号：US15221612
申请日：2016-07-28
申请人： Karl Sebastian Lang , Bernhard Singer , Vishal Khairnar , Vikas Duhan , Universitaet Duisburg-Essen
IPC分类号： C07K16/28 , C12N5/0783
CPC分类号： C07K16/2803 , A61K39/095 , A61K39/102 , A61K39/1045 , C07K2317/24 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N5/0638 , C12N2501/58 , Y02A50/466
摘要： An anti-CEACAM1 antibody includes at least one antibody heavy chain (VH) domain having antigen binding sites CDR1H, CDR2H and CDR3H, and at least one antibody light chain (VL) domain having antigen binding sites CDR1L, CDR2L and CDR3L. The antigen binding site CDR2H has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).
摘要翻译： 抗CEACAM1抗体包括至少一个具有抗原结合位点CDR1H，CDR2H和CDR3H的抗体重链（VH）结构域和至少一个具有抗原结合位点CDR1L，CDR2L和CDR3L的抗体轻链（VL）结构域。 抗原结合位点CDR2H与氨基酸序列WINTYTGEPT（SEQ ID No.21）具有至少80％的序列同源性。
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8.发明申请Use of Preparations Comprising Exosomes Derived From Mesenchymal Stem Cells (MSCs) in the Prevention and Therapy of Inflammatory Conditions 有权在来自间充质干细胞（MSC）的外来体的预防和治疗炎症病症中的应用公开(公告)号：US20150190429A1
公开(公告)日：2015-07-09
申请号：US14414843
申请日：2013-07-18
发明人： Dietrich Wilhelm Beelen , Thorsten Deoppner , Ursula Felderhoff-Mueser , Bernd Giebel , Dirk Hermann , Peter Horn , Matthias Keller , Lambros Kordelas , Anna-Kristin Ludwig , Vera Rebmann
CPC分类号： A61K35/28 , A61K9/0019 , A61K38/17 , A61K38/1709 , A61K38/1841 , A61K38/19 , A61K38/2053 , A61K38/2066 , A61K38/217
摘要： The present invention relates to the use of exosome-preparations derived from neonatal or adult tissue-derived mesenchymal stem-cells (MSCs) for the prevention or for therapy of inflammatory conditions, such as, for example, pre- and postnatally acquired damages of the brain (i.e. neuronal damages) or in complications following stem cell transplantation (“graft vs host-disease”, GvHD).
摘要翻译： 本发明涉及来自新生儿或成体组织的间充质干细胞（MSC）的外来物质制剂用于预防或治疗炎性病症的用途，例如，对于 脑干（即神经元损伤）或干细胞移植后的并发症（“移植物抗宿主病”，GvHD）。
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公开(公告)号：US20140171523A1
公开(公告)日：2014-06-19
申请号：US14089393
申请日：2013-11-25
发明人： Marcus Lau , Stephan Barcikowski
CPC分类号： B01F3/1235 , A61K33/24 , A61K49/0065 , B22F1/0018 , B22F1/0022 , B22F9/04 , B23K26/352 , B82Y30/00 , G01N33/553 , G01N33/587
摘要： The invention provides a process for the production of nanoparticles as well as a device that is disposed for the production of the nanoparticles. The process is especially characterized in that the nanoparticles are pure, especially free from organic carbon compounds, preferably carbon-free, and are obtained continuously. The nanoparticles which are obtainable by the process of the invention are characterized in that they are present without an organic ligand in suspension and are especially preferred stable as a suspension against agglomeration, wherein the medium having the particles suspended therein is free from organic carbon compounds, especially carbon-free.
摘要翻译： 本发明提供了制备纳米颗粒的方法以及为制备纳米颗粒而设置的装置。 该方法的特征在于纳米颗粒是纯的，特别是没有有机碳化合物，优选不含碳，并连续获得。 可通过本发明的方法获得的纳米颗粒的特征在于它们在悬浮液中不存在有机配体，特别优选作为悬浮液的悬浮液稳定，其中悬浮在其中的颗粒不含有机碳化合物， 特别是无碳。
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公开(公告)号：US20180014830A1
公开(公告)日：2018-01-18
申请号：US15546913
申请日：2016-04-06
发明人： Till NEUMANN , Torsten SCHEUERMANN , Niklas NATHE
CPC分类号： A61B17/12109 , A61B17/1214 , A61B17/12172 , A61B2017/00867 , A61B2017/1205 , A61B2017/22038 , A61F2/246 , A61F2/2466 , A61F2/962 , A61F2/966 , A61F2002/011 , A61F2002/9505 , A61F2002/9511 , A61F2002/9665
摘要： A system for inserting an implant at an implantation site has a tubular catheter through which the implant to be installed is transported in a longitudinal travel direction to the implantation site. A ring is spaced forward in the direction to the implantation site from the implant and is longitudinally coupled to the implant. A guide wire in the tubular catheter also can pass through the ring. A push tube in the tubular catheter the guide wire is slidable on the guide wire longitudinally forward toward the implantation site and has a front end closer to the implantation site and for which the ring forms an impenetrable stop.
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