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公开(公告)号：US20240173258A1
公开(公告)日：2024-05-30
申请号：US18499655
申请日：2023-11-01
Inventor： Yana K. RESHETNYAK , Oleg A. ANDREEV , Donald M. ENGELMAN
IPC: A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/69 , A61P35/00
CPC classification number: A61K9/1271 , A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/6911 , A61P35/00
Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
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公开(公告)号：US11993355B2
公开(公告)日：2024-05-28
申请号：US17515933
申请日：2021-11-01
Applicant: University of Rhode Island Board of Trustees
Inventor： Dillon Fontaine , Arun Shukla
Abstract: Structures designed to mitigate implosion pressure spikes through the use of an external sacrificial confining structure. Such improved structures can, in some embodiments, completely surround the existing structures that are at a high risk of imploding. The improved structures can slow the rate at which the surrounding fluid media volume is consumed by providing resistance to flow into the enclosure.
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公开(公告)号：US20240141368A1
公开(公告)日：2024-05-02
申请号：US18495731
申请日：2023-10-26
Applicant: University of Rhode Island Board of Trustees , The Regents of the University of California
Inventor： Albert P. Kausch , Markita Landry
CPC classification number: C12N15/8229 , C12N9/22 , C12N2310/20
Abstract: Described herein are methods and compositions for direct genome editing in vivo in plants by targeting cells in the shoot apical meristem.
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14.发明公开公开(公告)号：US20240075170A1
公开(公告)日：2024-03-07
申请号：US18349855
申请日：2023-07-10
Inventor： Yana K. RESHETNYAK , Oleg A. ANDREEV , Donald M. ENGELMAN
IPC: A61K49/00 , A61B5/00 , A61K49/04 , A61K49/22 , C07K14/00 , C07K19/00 , C09B69/10 , C09K11/06 , G01N33/58
CPC classification number: A61K49/0056 , A61B5/0082 , A61K49/0034 , A61K49/04 , A61K49/221 , A61K49/227 , C07K14/001 , C07K19/00 , C09B69/107 , C09K11/06 , G01N33/582 , A61B5/0071 , C09K2211/1466
Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
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15.发明授权公开(公告)号：US11860059B2
公开(公告)日：2024-01-02
申请号：US16888726
申请日：2020-05-30
Inventor： Carmen J. Quartapella , Mookkan Periyasamy , Elizabeth Sassano , Otto J. Gregory , Godi Fischer , Tao Wei , Zakary Kinzel , Noah A. Burke
IPC: G01M13/005 , G01M13/003 , H01J37/32
CPC classification number: G01M13/005 , G01M13/003 , H01J37/32513
Abstract: Methods, systems and a self-sensing valve assembly are described for monitoring seal life. The method includes providing a valve assembly movable from an open position to a closed position and including a seal seated within the valve and in contact with a surface of the valve assembly, wherein when the seal is in operation it is subject to degradation. At least one sensor is placed for measuring micro strain on a surface of the valve assembly or within the valve assembly. The valve assembly is placed in an operation wherein the seal is subject to degradation and the operation of the valve assembly is initiated. At a time after the operation is initiated, micro strain data is recorded and at least one other property related to a condition selected from an ambient condition of operation and a condition related to degradation of the seal is recorded; and the recorded data is analyzed against baseline data associated with 100% seal life to evaluate seal life at the time after the operation is initiated as a percentage of seal life less than 100%.
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Patent Agency Ranking
公开(公告)号：US20230365818A1
公开(公告)日：2023-11-16
申请号：US18316280
申请日：2023-05-12
Applicant: UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES
Inventor： Noah Burke , Panagiotis Panoutsopoulos , Zachary Ahlquist , Otto J. Gregory
IPC: C09D5/26 , C09D101/26 , C09D7/61 , G01K1/022 , G01K11/125
CPC classification number: C09D5/26 , C09D101/26 , C09D7/61 , G01K1/022 , G01K11/125
Abstract: Temperature measurements are critical in gas turbine engine design but difficult to obtain due to the extreme environment. Temperature indicating paints (thermal paints) have been used for decades to map maximum temperature fields on superalloy components but have numerous weaknesses. Disclosed herein are novel glass ceramic thermal paints that undergo viscous flow sintering to indicate temperatures up to 1000° C., with high resolution (±5° C.), by an optical transition. Disclosed paint formulations are designed to adhere to Nickel-based superalloys or SiC—SiC ceramic matrix composites (CMC) by closely matching coefficients of thermal expansion and may function for times above 60 hours. By utilizing automation and a UV:VIS spectrometer, quantitative temperature maps can be generated for easy comparison to theoretical models. A transient sintering energy model is disclosed to recover full thermal history information.
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公开(公告)号：US11177505B2
公开(公告)日：2021-11-16
申请号：US16475563
申请日：2018-01-02
Applicant: BASF SE , University of Rhode Island Board of Trustees
Inventor： Frederick Francois Chesneau , Arnd Garsuch , Michael Schmidt , Brett Lucht , Julien Demeaux , Yingnan Dong , Bo Zhang
IPC: H01M10/0567 , H01M10/0525 , H01M10/0568 , H01M10/0569
Abstract: An electrolyte composition including (i) at least one aprotic organic solvent; (ii) at least one conducting salt; (iii) at least one pyridine-SO3 complex of formula (I) wherein R is selected independently at each occurrence from F, C1 to C10 alkyl, C2 to C10 alkenyl, and C2 to C10 alkynyl, wherein alkyl, alkenyl, and alkynyl may be substituted by one or more substituents selected from F and CN; and n is an integer selected from 1, 2, 3, 4, and 5; and (vi) optionally one or more additives; and its use in electrochemical cells.
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公开(公告)号：US20210325329A1
公开(公告)日：2021-10-21
申请号：US17232624
申请日：2021-04-16
Inventor： Y.M. Nuwan D.Y. Bandara , Buddini I. Karawdeniya , Jugal Saharia , Min Jun Kim , Jason Rodger Dwyer
IPC: G01N27/12
Abstract: The present invention includes one or more nanopores in a SixNy membrane comprising a monoprotic surface termination, methods of making, and methods of using the one or more nanopores, where the one or more nanopores are a chemically-tuned controlled dielectric breakdown (CT-CDB) nanopore membrane, wherein the CT-CDB allows for long-term stability of measurements in the presence of only electrolyte (open pore current stability) and ability to support many molecular detection events. In addition, the CT-CBD has pore that unclog spontaneously, in response to voltage cessation or application, or both.
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19.发明申请公开(公告)号：US20200378867A1
公开(公告)日：2020-12-03
申请号：US16888726
申请日：2020-05-30
Inventor： Carmen J. Quartapella , Mookkan Periyasamy , Elizabeth Sassano , Otto J. Gregory , Godi Fischer , Tao Wei , Zakary Kinzel , Noah A. Burke
IPC: G01M13/005 , H01J37/32 , G01M13/003
Abstract: Methods, systems and a self-sensing valve assembly are described for monitoring seal life. The method includes providing a valve assembly movable from an open position to a closed position and including a seal seated within the valve and in contact with a surface of the valve assembly, wherein when the seal is in operation it is subject to degradation. At least one sensor is placed for measuring micro strain on a surface of the valve assembly or within the valve assembly. The valve assembly is placed in an operation wherein the seal is subject to degradation and the operation of the valve assembly is initiated. At a time after the operation is initiated, micro strain data is recorded and at least one other property related to a condition selected from an ambient condition of operation and a condition related to degradation of the seal is recorded; and the recorded data is analyzed against baseline data associated with 100% seal life to evaluate seal life at the time after the operation is initiated as a percentage of seal life less than 100%.
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公开(公告)号：US20200347345A1
公开(公告)日：2020-11-05
申请号：US16866265
申请日：2020-05-04
Applicant: University of Rhode Island Board of Trustees
Inventor： David R. Nelson , Jason LaPorte , David C. Rowley , Marta Gomez-Chiarri
IPC: C12N1/20 , A61K35/741
Abstract: The invention provides a method and related compositions for preparing an effective probiotic bacteria formulation that can be stored, transported and used for protecting a variety of marine organisms against infection by potential pathogens.
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