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公开(公告)号:US11932558B1
公开(公告)日:2024-03-19
申请号:US17190248
申请日:2021-03-02
发明人: William B. Euler , Angela Thach , Lasanthi Sumathirathne , Benjamin B. Cromwell , Mara Dubnicka
IPC分类号: C02F1/461 , C02F1/467 , C02F101/34 , C02F101/38 , C25B1/04 , C25B1/27 , C25B3/07 , C25B3/26 , C25B11/095 , H10N30/857
CPC分类号: C02F1/46109 , C02F1/4672 , C25B1/04 , C25B1/27 , C25B3/07 , C25B3/26 , C25B11/095 , H10N30/857 , C02F2001/46133 , C02F2101/345 , C02F2101/38 , C02F2201/46115
摘要: A piezoelectric polymer used as a piezocatalyst, and methods of manufacture and use therefor. A preferred piezoelectric polymer is poly(vinylidene difluoride) (PVDF) due to its piezoelectric response and good flexibility. The polymer can be doped with a metal, metal salt, metal carbonyl, metal oxide such as ZnO, Co2O3, or TiO2, or ion such as Cr3+, Co2+, or Zn2+. The dopant can be chosen so that when the polymer is PVDF the dopant increases the amount of β-phase PVDF and/or γ-phase PVDF relative to α-phase PVDF, thereby increasing the piezocatalytic response of the polymer. The compound to be decomposed can be adsorbed on the surface of the piezoelectric polymer. Applications include wastewater treatment, CO2 capture and reduction, hydroformylation, water splitting, and ammonia synthesis.
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公开(公告)号:US20240066096A1
公开(公告)日:2024-02-29
申请号:US18325884
申请日:2023-05-30
CPC分类号: A61K38/16 , A61K38/195 , A61K38/20 , A61K47/00 , A61K2121/00 , C07K2319/33
摘要: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP● construct comprising an antibody recruiting molecule linked to one or more pHLIP● peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
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公开(公告)号:US20230372551A1
公开(公告)日:2023-11-23
申请号:US18027337
申请日:2021-09-21
申请人: MEMORIAL SLOAN-KETTERING CANCER CENTER , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , SLOAN-KETTERING INSTITUTE OF CANCER RESEARCH , UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES , PHLIP, INC.
CPC分类号: A61K51/088 , C07K14/001 , A61K2123/00
摘要: The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
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公开(公告)号:US11572417B2
公开(公告)日:2023-02-07
申请号:US16870829
申请日:2020-05-08
发明人: Teresa L. Mako , Mindy Levine , Jason Dwyer
摘要: The invention provides a mild procedure for the functionalization of cellulose and other substrates with a detection reagent such as N-(1-naphthyl)ethylenediamine and is able to achieve much higher functionalization density than previously reported. A paper-based device created using cellulose functionalized according to the invention allowed for much lower detection limits for nitrite in various kinds of water samples than have been seen using paper-based devices. In addition, grafting of N-(1-naphthyl)ethylenediamine to cellulose improved the stability of the N-(1-naphthyl)ethylenediamine in the presence of moisture and light.
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公开(公告)号:US20220259433A1
公开(公告)日:2022-08-18
申请号:US17588674
申请日:2022-01-31
发明人: Sumeru Nayak , Sumanta Das
IPC分类号: C08L91/00 , C08K3/04 , C09D7/61 , C09D5/10 , C09D191/00
摘要: A composition and method of synthesizing a composition from organic oils and industrial byproducts for use as a corrosion inhibitor coating is disclosed. The synthesis of a rapid setting ionomer is the result of iron-induced polymerization of oleic and linoleic acids, where an alkaline ionomeric reaction is facilitated with a small fraction of pure aluminum leaf at room temperature. At least one alkaline reagent is employed with at least one metallic additive to form metal complex ionomers that form a solid polymer. The resulting ionomer is stirred and applied on the substrate as a surface coating and it starts setting in less than thirty minutes.
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公开(公告)号:US20220248983A1
公开(公告)日:2022-08-11
申请号:US17590032
申请日:2022-02-01
摘要: An optical core-shell microfibrous textile incorporates single-walled carbon nanotubes (SWCNTs) for the real-time optical monitoring of hydrogen peroxide concentrations and other biochemicals in in vitro wounds. The environmentally sensitive and non-photo-bleachable fluorescence of SWCNTs enable continuous analyte monitoring without a decay in signal over time. The microfibrous textiles spatially resolve chemical indicator concentrations using a camera and are integrated into commercial wound bandages without significant degradation in their optical properties.
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公开(公告)号:US10782190B1
公开(公告)日:2020-09-22
申请号:US16221270
申请日:2018-12-14
摘要: A resistance temperature detector (RTD) that uses a ceramic matrix composite (CMC), such as a silicon carbide fiber-reinforced silicon carbide matrix, as an active temperature sensing element, which can operate at temperatures greater than 1000° C. or even 1600° C. Conductive indium tin oxide or a single elemental metal such as platinum is deposited on a dielectric or insulating layer such as mullite or an environmental barrier coating (EBC) on the substrate. Openings in the layer allow etching of the CMC surface in order to make high quality ohmic contacts with the conductive material, either directly or through a silicide diffusion barrier such as ITO. The RTD can measure both temperature and strain of the CMC. The use of an EBC, which typically is deposited on the CMC by the manufacturer, as the insulating or dielectric layer can be extended to other devices such as strain gages and thermocouples that use the CMC as a sensing element. The EBC can be masked and etched to form the openings. A conductive EBC can be used as the silicide diffusion barrier.
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公开(公告)号:US20240255378A1
公开(公告)日:2024-08-01
申请号:US18402623
申请日:2024-01-02
发明人: Carmen J. Quartapella , Mookkan Periyasamy , Elizabeth Sassano , Otto J. Gregory , Godi Fischer , Tao Wei , Zakary Kinzel , Noah A. Burke
IPC分类号: G01M13/005 , G01M13/003 , H01J37/32
CPC分类号: G01M13/005 , G01M13/003 , H01J37/32513
摘要: Methods, systems and a self-sensing valve assembly are described for monitoring seal life. The method includes providing a valve assembly movable from an open position to a closed position and including a seal seated within the valve and in contact with a surface of the valve assembly, wherein when the seal is in operation it is subject to degradation. At least one sensor is placed for measuring micro strain on a surface of the valve assembly or within the valve assembly. The valve assembly is placed in an operation wherein the seal is subject to degradation and the operation of the valve assembly is initiated. At a time after the operation is initiated, micro strain data is recorded and at least one other property related to a condition selected from an ambient condition of operation and a condition related to degradation of the seal is recorded; and the recorded data is analyzed against baseline data associated with 100% seal life to evaluate seal life at the time after the operation is initiated as a percentage of seal life less than 100%.
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公开(公告)号:US20240173258A1
公开(公告)日:2024-05-30
申请号:US18499655
申请日:2023-11-01
IPC分类号: A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/69 , A61P35/00
CPC分类号: A61K9/1271 , A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/6911 , A61P35/00
摘要: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
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公开(公告)号:US11993355B2
公开(公告)日:2024-05-28
申请号:US17515933
申请日:2021-11-01
发明人: Dillon Fontaine , Arun Shukla
摘要: Structures designed to mitigate implosion pressure spikes through the use of an external sacrificial confining structure. Such improved structures can, in some embodiments, completely surround the existing structures that are at a high risk of imploding. The improved structures can slow the rate at which the surrounding fluid media volume is consumed by providing resistance to flow into the enclosure.
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