公开(公告)号：US5221760A

公开(公告)日：1993-06-22

申请号：US891629

申请日：1992-06-01

Applicant: Ulrich Rosentreter ,  Harold C. Kluender ,  Trevor S. Abram ,  Peter Norman ,  Steven R. Tudhope

Inventor： Ulrich Rosentreter ,  Harold C. Kluender ,  Trevor S. Abram ,  Peter Norman ,  Steven R. Tudhope

IPC: C07C43/225 ,  C07C43/23 ,  C07C63/14 ,  C07C65/24 ,  C07C309/73 ,  C07C323/56 ,  C07F7/18 ,  C07F9/54

CPC classification number: C07F9/5456 ,  C07C309/73 ,  C07C323/56 ,  C07C43/225 ,  C07C43/23 ,  C07C63/14 ,  C07C65/24 ,  C07F7/1852 ,  C07F9/5407

Abstract: An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH.sub.2 --, or oxygen or a direct bond,W represents --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --,o represents a number 1 to 5,A and B are identical or different and represent carboxyl, carboxymethylene, tetrazolyl or tetrazolylmethylene, or --CO.sub.2 R.sup.9 or --CH.sub.2 CO.sub.2 R.sup.9 or --CONR.sup.10 R.sup.11 or nitrilen represents a number 1 to 10,m represents a number 0 to 7,T and Z are identical or different and represent oxygen or a direct bond andR.sup.2, R.sup.3, R.sup.8 are identical or different and represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro andR.sup.9 is lower alkyl and R.sup.10 and R.sup.11 are hydrogen, lower alkyl, alkylsulfonyl or arylsulfonyl or together are an alkylene chain to form a ringand pharmaceutically acceptable salts thereof. Such alkenoic acid derivatives are useful as leucotriene disease antagonists.

Abstract translation: 其中X和Y相同或不同并表示硫，亚砜，砜，亚烷基链，-SCH 2 - 或氧或直接键的式（I）的链烯酸衍生物，W表示-CH = CH-或-CH 2 -CH 2 - ，o表示数1至5，A和B相同或不同，表示羧基，羧基亚甲基，四唑基或四唑基亚甲基，或-CO 2 R 9或-CH 2 CO 2 R 9或-CONR 10 R 11或腈n表示1 至10，m表示0至7的数，T和Z相同或不同，表示氧或直接键，R2，R3，R8相同或不同，表示氢，烷基，烷氧基，卤素，三氟甲基，三氟甲氧基，氰基 或硝基，R 9为低级烷基，R 10和R 11为氢，低级烷基，烷基磺酰基或芳基磺酰基，或一起为形成环的亚烷基链及其药学上可接受的盐。 这样的链烯酸衍生物可用作白三烯类疾病拮抗剂。

公开(公告)号：US5159097A

公开(公告)日：1992-10-27

申请号：US618184

申请日：1990-11-26

Applicant: Ulrich Rosentreter ,  Harold C. Kluender ,  Trevor S. Abram ,  Peter Norman ,  Steven R. Tudhope

Inventor： Ulrich Rosentreter ,  Harold C. Kluender ,  Trevor S. Abram ,  Peter Norman ,  Steven R. Tudhope

IPC: A61K31/19 ,  A61K31/215 ,  A61K31/235 ,  A61K31/275 ,  A61K31/41 ,  A61P11/08 ,  A61P43/00 ,  C07C43/225 ,  C07C43/23 ,  C07C51/353 ,  C07C63/14 ,  C07C63/66 ,  C07C65/24 ,  C07C65/28 ,  C07C67/343 ,  C07C69/76 ,  C07C69/94 ,  C07C309/73 ,  C07C317/44 ,  C07C317/46 ,  C07C319/20 ,  C07C323/52 ,  C07C323/56 ,  C07C323/62 ,  C07C323/65 ,  C07D257/06 ,  C07F7/18 ,  C07F9/54

CPC classification number: C07F9/5456 ,  C07C309/73 ,  C07C323/56 ,  C07C43/225 ,  C07C43/23 ,  C07C63/14 ,  C07C65/24 ,  C07F7/1852 ,  C07F9/5407

Abstract: An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH.sub.2 --, or oxygen or a direct bond,W represents --CH.dbd.CH--or --CH.sub.2 --CH.sub.2 --,o represents a number 1 to 5,A and B are identical or different and represent carboxyl, carboxymethylene, tetrazolyl or tetrazolylmethylene, or --CO.sub.2 R.sup.9 or --CH.sub.2 CO.sub.2 R.sup.9 or --CONR.sup.10 R.sup.11 or nitrilen represents a number 1 to 10,m represents a number 0 to 7,T and Z are identical or different and represent oxygen or a direct bond andR.sup.2, R.sup.3, R.sup.8 are identical or different and represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro andR.sup.9 is lower alkyl and R.sup.10 and R.sup.11 are hydrogen, lower alkyl, alkylsulfonyl or arylsulfonyl or together are an alkylene chain to form a ringand pharmaceutically acceptable salts thereof. Such alkenoic acid derivatives are useful as leucotriene disease antagonists.

Abstract translation: 其中X和Y相同或不同并表示硫，亚砜，砜，亚烷基链，-SCH 2 - 或氧或直接键的式（I）的链烯酸衍生物，W表示-CH = CH-或-CH 2 -CH 2 - ，o表示数1至5，A和B相同或不同，表示羧基，羧基亚甲基，四唑基或四唑基亚甲基，或-CO 2 R 9或-CH 2 CO 2 R 9或-CONR 10 R 11或腈n表示1 至10，m表示0至7的数，T和Z相同或不同，表示氧或直接键，R2，R3，R8相同或不同，表示氢，烷基，烷氧基，卤素，三氟甲基，三氟甲氧基，氰基 或硝基，R 9为低级烷基，R 10和R 11为氢，低级烷基，烷基磺酰基或芳基磺酰基，或一起为形成环的亚烷基链及其药学上可接受的盐。 这样的链烯酸衍生物可用作白三烯类疾病拮抗剂。

公开(公告)号：US4882353A

公开(公告)日：1989-11-21

申请号：US263143

申请日：1988-10-26

Applicant: Ulrich Niewohner ,  Franz-Peter Hoever ,  Folker Lieb ,  Hermann Oediger ,  Ulrich Rosentreter ,  Horst Boshagen ,  Elisabeth Perzborn ,  Volker-Bernd Fiedler ,  Friedel Seuter

Inventor： Ulrich Niewohner ,  Franz-Peter Hoever ,  Folker Lieb ,  Hermann Oediger ,  Ulrich Rosentreter ,  Horst Boshagen ,  Elisabeth Perzborn ,  Volker-Bernd Fiedler ,  Friedel Seuter

IPC: A61K31/35 ,  A61K31/352 ,  A61P7/02 ,  C07D311/58 ,  C07D311/60 ,  C07D311/64 ,  C07D311/68 ,  C07D311/96

CPC classification number: C07D311/96 ,  C07D311/58 ,  C07D311/60 ,  C07D311/64 ,  C07D311/68

Abstract: For inhibiting thombocyte aggregation, vasodilating and bronchodilating, the new chroman derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, alkyl, hydroxyl, alkoxy, trifluoromethyl or cyano,R.sup.2 and R.sup.3 are identical or different and stand for hydrogen, alkyl, cycloalkyl or aryl,R.sup.4 stands for hydroxyl, alkoxy, aryloxy, aralkoxy or for a group of the formula --NR.sup.5 R.sup.6, whereR.sup.5 and R.sup.6 are identical or different and in each case denote hydrogen, alkyl, aryl or aralkyl,X denotes a direct bond or an oxygen or sulphur atom, NH or N-alkyl, andn denotes 0 or 1,and their physiologically tolerable salts. Also new intermediates of the formulas ##STR2##

Abstract translation: 为了抑制血管细胞聚集，血管扩张和支气管扩张，式（Ⅰ）中R1代表氢，卤素，烷基，羟基，烷氧基，三氟甲基或氰基，R2和R3的新的苯并二氢吡喃衍生物是相同或不同的， 对于氢，烷基，环烷基或芳基，R4代表羟基，烷氧基，芳氧基，芳烷氧基或式-NR5R6基团，其中R5和R6相同或不同，并且在每种情况下都表示氢，烷基，芳基或芳烷基， X表示直接键或氧或硫原子，NH或N-烷基，n表示0或1，以及它们的生理上可耐受的盐。 （IMA）>（IV）的新中间体

公开(公告)号：US4868332A

公开(公告)日：1989-09-19

申请号：US123748

申请日：1987-11-23

Applicant: Ulrich Niewohner ,  Franz-Peter Hoever ,  Folker Lieb ,  Ulrich Rosentreter ,  Elisabeth Perzborn ,  Volker-Bernd Fiedler ,  Friedel Seuter

Inventor： Ulrich Niewohner ,  Franz-Peter Hoever ,  Folker Lieb ,  Ulrich Rosentreter ,  Elisabeth Perzborn ,  Volker-Bernd Fiedler ,  Friedel Seuter

IPC: C07C49/747 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61P7/02 ,  A61P9/10 ,  C07C45/00 ,  C07C67/00 ,  C07C69/675 ,  C07C213/00 ,  C07C217/74 ,  C07C231/00 ,  C07C231/12 ,  C07C235/20 ,  C07C253/00 ,  C07C255/47 ,  C07C307/02 ,  C07C311/17 ,  C07C311/21

CPC classification number: A61K31/215 ,  A61K31/18 ,  C07C307/02

Abstract: An aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivative of the formula ##STR1## in which R.sup.3 is aryl or substituted aryl,R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,and physiologically acceptable salts thereof with monovalent or divalent cations which have antithrombotic, antiatherosclerotic and antiischaemic activities.

Abstract translation: 其中R3是芳基或取代的芳基，R2是羟基，烷氧基，苯氧基，苯氧基或NR4R5的氨基甲基-5,6,7,8-四氢萘基 - 氧基乙酸衍生物，其中R 4和R 5各自独立地是 氢或烷基，或者基团R4或R5中的一个为苄基，以及其与具有抗血栓形成，抗动脉粥样硬化和抗神经活性的单价或二价阳离子的生理上可接受的盐。

公开(公告)号：US4853406A

公开(公告)日：1989-08-01

申请号：US200342

申请日：1988-05-31

Applicant: Ulrich Rosentreter ,  Horst Boshagen ,  Folker Lieb ,  Hermann Oediger ,  Ulrich Niewohner ,  Friedel Seuter ,  Elisabeth Perzborn ,  Volker-Bernd Fiedler

Inventor： Ulrich Rosentreter ,  Horst Boshagen ,  Folker Lieb ,  Hermann Oediger ,  Ulrich Niewohner ,  Friedel Seuter ,  Elisabeth Perzborn ,  Volker-Bernd Fiedler

IPC: A61K31/40 ,  A61K31/403 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/08 ,  A61P37/08 ,  C07D209/90

CPC classification number: C07D209/90

Abstract: Thrombocyte aggregation-inhibiting polyhydrobenz[c,d]indolesulphonamide of the formula ##STR1## in which R.sup.1 is hydrogen, aryl or alkyl,R.sup.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, hydroxyl, aralkoxy ora group of the formula ##STR2## R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, aryl, aralkyl or acyl andX is cyano or carboxyl, and salts thereof. Intermediates therefor of the formula ##STR3## are also new.

Abstract translation: R 1为氢，芳基或烷基，R 2为氢，卤素，烷基，烷氧基，三氟甲基，三氟甲氧基，羟基，芳烷氧基或基团的式（I）的血小板聚集抑制性多羟基苯并[c，d]吲哚磺酰胺 式R 3和R 4各自独立地为氢，烷基，芳基，芳烷基或酰基，X为氰基或羧基，及其盐。 具有公式（II）的中间体也是新的。

公开(公告)号：US07691854B2

公开(公告)日：2010-04-06

申请号：US10525867

申请日：2003-08-18

Applicant: Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenich ,  Mary F. Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

Inventor： Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenich ,  Mary F. Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

IPC: A61K31/44 ,  C07D213/72 ,  C07D401/02

CPC classification number: C07D401/04 ,  C07D211/90 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

Abstract: The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

Abstract translation: 本发明涉及式（I）的新型二氢吡啶衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。

公开(公告)号：US20090221649A1

公开(公告)日：2009-09-03

申请号：US11887062

申请日：2006-03-11

Applicant: Thomas Krahn ,  Thomas Krämer ,  Ulrich Rosentreter ,  James M. Downey ,  Natalia Solenkova

Inventor： Thomas Krahn ,  Thomas Krämer ,  Ulrich Rosentreter ,  James M. Downey ,  Natalia Solenkova

IPC: A61K31/44 ,  C07D211/72 ,  A61P9/00

CPC classification number: A61K31/44

Abstract: The invention relates to substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines of formula (I) and their use in medicaments for the prophylaxis and/or treatment of reperfusion injury and damage.

Abstract translation: 本发明涉及式（I）的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶及其在药物中的用途，用于预防和/或治疗再灌注损伤和损伤。

公开(公告)号：US20080261990A1

公开(公告)日：2008-10-23

申请号：US11663813

申请日：2005-09-10

Applicant: Elke Dittrich-Wengenroth ,  Lars Barfacker ,  Axel Kretschmer ,  Claudia Hirth-Dietrich ,  Peter Ellinghaus ,  Martin Raabe ,  Hilmar Bischoff ,  Christian Pilger ,  Ulrich Rosentreter ,  Stephan Bartel ,  Klemens Lustig ,  Armin Kern ,  Dieter Lang ,  Marcus Bauser

Inventor： Elke Dittrich-Wengenroth ,  Lars Barfacker ,  Axel Kretschmer ,  Claudia Hirth-Dietrich ,  Peter Ellinghaus ,  Martin Raabe ,  Hilmar Bischoff ,  Christian Pilger ,  Ulrich Rosentreter ,  Stephan Bartel ,  Klemens Lustig ,  Armin Kern ,  Dieter Lang ,  Marcus Bauser

IPC: A61K31/496 ,  C07D405/12 ,  A61K31/506 ,  C07D239/28 ,  A61K31/505

CPC classification number: C07D239/42 ,  C07D405/12

Abstract: The present invention relates to novel pyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidemias, arteriosclerosis, coronary heart disease, thrombosis and metabolic syndrome.

Abstract translation: 本发明涉及新颖的嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防心血管疾病，特别是血脂异常，动脉硬化，冠心病，血栓形成和代谢综合征。

公开(公告)号：US20080255202A1

公开(公告)日：2008-10-16

申请号：US11547974

申请日：2005-03-26

Applicant: Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Nils Griebenow ,  Axel Kretschmer ,  Joachim Kruger ,  Elisabeth Woltering ,  Lars Barfacker ,  Claudia Hirth-Dietrich ,  Peter Ellinghaus ,  Martin Raabe ,  Stephen Bartel ,  Christian Pilger ,  Ulrich Rosentreter ,  Klemens Lustig ,  Armin Kern ,  Dieter Lang

Inventor： Hilmar Bischoff ,  Elke Dittrich-Wengenroth ,  Nils Griebenow ,  Axel Kretschmer ,  Joachim Kruger ,  Elisabeth Woltering ,  Lars Barfacker ,  Claudia Hirth-Dietrich ,  Peter Ellinghaus ,  Martin Raabe ,  Stephen Bartel ,  Christian Pilger ,  Ulrich Rosentreter ,  Klemens Lustig ,  Armin Kern ,  Dieter Lang

IPC: A61K31/4427 ,  C07D271/06 ,  A61K31/4245 ,  C07D261/06 ,  A61K31/42 ,  C07D271/10 ,  C07D231/10 ,  C07D213/02 ,  A61P9/00 ,  A61K31/4155 ,  C07D277/20 ,  A61K31/427 ,  C07D249/08 ,  A61K31/4196 ,  C07D233/54

CPC classification number: C07D405/12 ,  C07D231/12 ,  C07D249/04 ,  C07D263/32 ,  C07D271/06 ,  C07D277/28 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present application relates to novel phenylthioacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.

Abstract translation: 本申请涉及新的苯硫基乙酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管疾病，特别是血脂异常和动脉硬化。

公开(公告)号：US20080004275A1

公开(公告)日：2008-01-03

申请号：US10594343

申请日：2005-03-11

Applicant: Holger Zimmermann ,  David Bruckner ,  Dirk Heimbach ,  Martin Hendrix ,  Kerstin Henninger ,  Guy Hewlett ,  Ulrich Rosentreter ,  Jorg Keldenich ,  Dieter Lang ,  Martin Radtke

Inventor： Holger Zimmermann ,  David Bruckner ,  Dirk Heimbach ,  Martin Hendrix ,  Kerstin Henninger ,  Guy Hewlett ,  Ulrich Rosentreter ,  Jorg Keldenich ,  Dieter Lang ,  Martin Radtke

IPC: A61K31/5377 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61P31/12 ,  C07D233/88 ,  C07D249/12 ,  C07D403/12 ,  C07D413/12 ,  C07D401/12 ,  C07D249/04 ,  C07D233/44 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/4439

CPC classification number: C07D233/90 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

Abstract: The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及式（I）的取代的咪唑及其制备方法，用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 特别是用作抗病毒药物，特别是针对巨细胞病毒。