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    UNIVERSAL HAIRPIN PRIMER SYSTEM FOR QUANTIFICATION OF MICRORNA
    13.
    发明申请
    UNIVERSAL HAIRPIN PRIMER SYSTEM FOR QUANTIFICATION OF MICRORNA 有权

    公开(公告)号：US20240401121A1

    公开(公告)日：2024-12-05

    申请号：US18694220

    申请日：2022-09-28

    Applicant: The University of Chicago

    Inventor： Tong-Chuan HE

    IPC: C12Q1/6853

    Abstract: The disclosure is directed to universal hairpin primer (UHP) nucleic acid molecules for quantifying RNA, including mature microRNA (miRNA), messenger RNA (mRNA), and long noncoding RNA (lncRNA), as well as systems and methods for using same. The UHP nucleic acid molecules comprise a stem-loop structure and a degenerate nucleic acid sequence of 2-10 (e.g., 2-6) nucleotides at the 3′ end, wherein the degenerate nucleic acid sequence hybridizes to the 3′-end of an RNA molecule. The RNA quantification analysis can be carried out by using either the conventional SYBR Green system or the cost-effective universal TaqMan probe-based RT-qPCR system.

    POLYPEPTIDES AND METHODS FOR MODIFYING NUCLEIC ACIDS
    15.
    发明公开
    POLYPEPTIDES AND METHODS FOR MODIFYING NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20240352439A1

    公开(公告)日：2024-10-24

    申请号：US18688268

    申请日：2022-09-02

    Applicant: THE UNIVERSITY OF CHICAGO

    Inventor： Weixin TANG ,  Yulan XIAO

    IPC: C12N9/78 ,  C12N9/22 ,  C12N15/10

    CPC classification number: C12N9/78 ,  C12N9/22 ,  C12N15/1058 ,  C12Y305/04004

    Abstract: The inventors have made TadA variants with improved activities, such as improved based editing in certain genomic contexts and altered editing window. Aspects of the disclosure relate to a polypeptide comprising SEQ ID NO: 1, wherein the polypeptide comprises one or more amino acid substitutions relative to SEQ ID NO: 1, wherein the one or more amino acid substitutions comprise a substitution at amino acid (23, 27, 36, 47, 48, 51, 76, 82, 106, 108, 109,110, 111, 114, 119, 122, 123, 126, 127, 146, 147, 152, 154, 155, 156, 157, 161, 166, 167), and combinations thereof.

    LOSS-RESILIENT REAL-TIME VIDEO STREAMING
    16.
    发明公开
    LOSS-RESILIENT REAL-TIME VIDEO STREAMING 审中-公开

    公开(公告)号：US20240340329A1

    公开(公告)日：2024-10-10

    申请号：US18626716

    申请日：2024-04-04

    Applicant: The University of Chicago

    Inventor： Junchen Jiang ,  Yihua Cheng ,  Ziyi Zhang ,  Hanchen Li

    IPC: H04L65/70 ,  H04L65/75

    CPC classification number: H04L65/70 ,  H04L65/762

    Abstract: Systems, methods, and computer program products are provided for streaming video over a network. In various embodiments, a source video including at least a source frame is read. The source frame is encoded into a corresponding tensor representation by a machine learning model. The corresponding tensor representation is decomposed into a plurality of sub-tensors. Each of the plurality of sub-tensors is encoded into a corresponding packet and transmitted via a network from a source node to a receiver node.

    Combined learned and dynamic control system
    17.
    发明授权
    Combined learned and dynamic control system 有权

    公开(公告)号：US12111619B2

    公开(公告)日：2024-10-08

    申请号：US17890907

    申请日：2022-08-18

    Applicant: The University of Chicago

    Inventor： Henry Hoffmann ,  Lester Teichner ,  Benjamin Vear

    IPC: G05B13/02 ,  G05B13/04 ,  G06F16/23 ,  G06F16/901

    CPC classification number: G05B13/0265 ,  G05B13/042 ,  G05B13/048 ,  G06F16/2358 ,  G06F16/9017

    Abstract: Example embodiments allow for networks of hybrid controllers that can be computed efficiently and that can adapt to changes in the system(s) under control. Such a network includes at least one hybrid controller that includes a dynamic sub-controller and a learned system sub-controller. Information about the ongoing performance of the system under control is provided to both the hybrid controller and to an over-controller, which provides one or more control inputs to the hybrid controller in order to modify the ongoing operation of the hybrid controller. These inputs can include the set-point of the hybrid controller, one or more parameters of the dynamic controller, and an update rate or other parameter of the learned system controller. The over-controller can control multiple hybrid controllers (e.g., controlling respective sub-systems of an overall system) and can, itself, be a hybrid controller.

    Photon-Number Dependent Hamiltonian Engineering for Resonators
    20.
    发明公开
    Photon-Number Dependent Hamiltonian Engineering for Resonators 审中-公开

    公开(公告)号：US20240303520A1

    公开(公告)日：2024-09-12

    申请号：US18271370

    申请日：2022-01-31

    Applicant: The University of Chicago ,  Yale University

    Inventor： Chiao-Hsuan Wang ,  Kyungjoo Noh ,  José Lebreuilly ,  Steven M. Girvin ,  Liang Jiang

    IPC: G06N10/40 ,  G06N10/20 ,  G06N10/70 ,  H01P7/06

    CPC classification number: G06N10/40 ,  G06N10/20 ,  G06N10/70 ,  H01P7/06

    Abstract: Cavity resonators are promising resources for quantum technology, while native nonlinear interactions for cavities are typically too weak to provide the level of quan-turn control required to deliver complex targeted operations. Here we investigate a scheme to engineer a target Hamiltonian for photonic cavities using ancilla qubits. By off-resonantly driving dispersively coupled ancilla qubits, we develop an optimized approach to engineering an arbitrary photon-number dependent (PND) Hamiltonian for the cavities while minimizing the operation errors. The engineered Hamiltonian admits various applications including canceling unwanted cavity self-Kerr interac-tions, creating higher-order nonlinearities for quantum simulations, and designing quantum gates resilient to noise. Our scheme can be implemented with coupled microwave cavities and transmon qubits in superconducting circuit systems.

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