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公开(公告)号：US5770222A
公开(公告)日：1998-06-23
申请号：US472305
申请日：1995-06-07
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC: A61B8/00 , A61K8/14 , A61K9/127 , A61K31/70 , A61K39/395 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC classification number: A61K49/22 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S436/829 , Y10S977/801 , Y10S977/907 , Y10S977/915
Abstract: Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
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公开(公告)号：US5469854A
公开(公告)日：1995-11-28
申请号：US76239
申请日：1993-06-11
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC: A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02 , A61K9/66
CPC classification number: A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61M5/3145 , Y10S977/795 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10S977/929 , Y10S977/962
Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
Abstract translation: 描述了制备充气脂质体的方法和装置。 通过这些方法制备的充气脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。
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公开(公告)号：US20100254904A1
公开(公告)日：2010-10-07
申请号：US11498331
申请日：2006-08-01
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
CPC classification number: A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/6925 , A61K49/223 , A61K49/227 , A61M5/3145
Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
Abstract translation: 描述了包含含有治疗剂的气体或气体前体填充的脂质微球的靶向治疗递送系统。 还提供了在治疗性递送应用中使用这种微球的方法。 包含气体或气态前体填充的脂质体的靶向治疗递送系统是优选的。 还公开了制备这种脂质体的方法和装置以及在治疗性递送应用中使用这种脂质体的方法。
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公开(公告)号：US06479034B1
公开(公告)日：2002-11-12
申请号：US09118329
申请日：1998-07-17
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC: A61B800
CPC classification number: A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/22 , A61K49/223 , A61M5/3145 , Y10S424/812 , Y10S436/829 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10S977/929
Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
Abstract translation: 描述了制备温度活化气态前体填充脂质体的方法和装置。 通过这些方法制备的气态前体填充脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。
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Patent Agency Ranking
公开(公告)号：US5935553A
公开(公告)日：1999-08-10
申请号：US758179
申请日：1996-11-25
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC: A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02
CPC classification number: A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61M5/3145 , Y10S977/795 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10S977/929 , Y10S977/962
Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
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公开(公告)号：US5542935A
公开(公告)日：1996-08-06
申请号：US160232
申请日：1993-11-30
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC: A61K8/14 , A61K9/127 , A61K9/14 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , A61M5/00 , A61B8/00
CPC classification number: A61K47/48869 , A61K41/0028 , A61K41/0052 , A61K47/48815 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S977/904 , Y10S977/907
Abstract: Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
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公开(公告)号：US07083572B2
公开(公告)日：2006-08-01
申请号：US10108284
申请日：2002-03-26
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
CPC classification number: A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/6925 , A61K49/223 , A61K49/227 , A61M5/3145
Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
Abstract translation: 描述了包含含有治疗剂的气体或气体前体填充的脂质微球的靶向治疗递送系统。 还提供了在治疗性递送应用中使用这种微球的方法。 包含气体或气态前体填充的脂质体的靶向治疗递送系统是优选的。 还公开了制备这种脂质体的方法和装置以及在治疗性递送应用中使用这种脂质体的方法。
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公开(公告)号：US5776429A
公开(公告)日：1998-07-07
申请号：US643070
申请日：1996-04-30
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC: A61B8/08 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02 , G01R33/28 , A61B8/13
CPC classification number: A61K9/1277 , A61K41/0028 , A61K41/0052 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1271 , A61K9/1278 , G01R33/5601 , A61M5/3145
Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
Abstract translation: 冻干脂质组合物及其制备方法由本发明体现。 使用冻干的脂质组合物制备的充气微球在例如超声成像应用和治疗药物递送系统中是特别有用的。
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公开(公告)号：US5715824A
公开(公告)日：1998-02-10
申请号：US471250
申请日：1995-06-06
Applicant: Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
Inventor： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC: A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02
CPC classification number: A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61M5/3145 , Y10S977/795 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10S977/929 , Y10S977/962
Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
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