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    Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
    2.
    发明授权
    Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same 失效
    涉及使用造影剂和多幅图像的超声成像方法及其处理方法

    公开(公告)号：US06231834B1

    公开(公告)日：2001-05-15

    申请号：US08982829

    申请日：1997-12-02

    申请人： Evan C. Unger ,  Thomas A. Fritz ,  Edward W. Gertz

    发明人： Evan C. Unger ,  Thomas A. Fritz ,  Edward W. Gertz

    IPC分类号： A61B813

    CPC分类号： B82Y5/00 ,  A61K49/223 ,  A61K49/227 ,  A61K49/228

    摘要： Improved methods for providing an image of an internal region of a patient. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises, in an aqueous carrier, a lipid, protein, polymer or surfactant, and a gas. The patient is scanned using ultrasound imaging to obtain a visible image of the region. In embodiments of the invention, the scanning step may comprise applying a first quantity of ultrasound energy to the patient to provide a first image, followed by the application substantially immediately thereafter of a second quantity of ultrasound energy to provide a second image. The first and second images are then processed. The methods are particularly useful for obtaining on-line images of the cardiovascular region which may be employed, for example, to diagnose the presence of diseased tissue in the cardiovascular region of a patient.

    摘要翻译： 用于提供患者内部区域的图像的改进方法。 本发明的实施方案涉及向患者施用造影剂，其在水性载体中包含脂质，蛋白质，聚合物或表面活性剂和气体。 使用超声成像扫描患者以获得该区域的可见图像。 在本发明的实施例中，扫描步骤可以包括向患者施加第一数量的超声能量以提供第一图像，随后基本上立即应用第二数量的超声能量以提供第二图像。 然后处理第一和第二图像。 该方法对于获得可用于例如诊断患者的心血管区域中患病组织的存在的心血管区域的在线图像特别有用。

    Methods for diagnostic imaging by regulating the administration rate of a contrast agent
    9.
    发明授权
    Methods for diagnostic imaging by regulating the administration rate of a contrast agent 失效
    通过调节造影剂的给药速率进行诊断成像的方法

    公开(公告)号：US6033645A

    公开(公告)日：2000-03-07

    申请号：US666129

    申请日：1996-06-19

    申请人： Evan C. Unger ,  Terry Matsunaga ,  Thomas A. Fritz ,  Varadarajan Ramaswami

    发明人： Evan C. Unger ,  Terry Matsunaga ,  Thomas A. Fritz ,  Varadarajan Ramaswami

    IPC分类号： A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02

    CPC分类号： A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

    摘要： Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

    摘要翻译： 提供患者内部区域的图像的方法。 该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。 该方法对于诊断患者中任何患病组织的存在特别有用。