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11.发明申请公开(公告)号：US20190383804A1
公开(公告)日：2019-12-19
申请号：US16375119
申请日：2019-04-04
Applicant: 10X Genomics, Inc.
Inventor： Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez
IPC: G01N33/53 , G01N33/543 , C12N15/11
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, epigenetic information (e.g., accessible chromatin, DNA methylation), and RNA molecules (e.g., mRNA or CRISPR guide RNAs). In some cases, the disclosed methods comprise analysis of analytes from a cell using a cell bead.
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公开(公告)号：US20190367969A1
公开(公告)日：2019-12-05
申请号：US16375093
申请日：2019-04-04
Applicant: 10X Genomics, Inc.
Inventor： Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez
IPC: C12Q1/6818 , C12Q1/6827
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins) and chromatin (e.g., accessible chromatin).
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公开(公告)号：US12201983B2
公开(公告)日：2025-01-21
申请号：US18376276
申请日：2023-10-03
Applicant: 10x Genomics, Inc.
Inventor： Rajiv Bharadwaj , Anthony Makarewicz , Bill Kengli Lin
IPC: B01L3/00 , B01F23/41 , B01F25/314 , B01F31/80 , B01F33/3011 , B01F33/302 , B01L3/02 , C12Q1/6806 , G01N1/00 , G01N33/543 , G01N33/58 , C12Q1/686 , C40B40/06
Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.
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公开(公告)号：US20240294975A1
公开(公告)日：2024-09-05
申请号：US18662508
申请日：2024-05-13
Applicant: 10x Genomics, Inc.
Inventor： Bill Kengli Lin , Jill Herschleb , Cedric Uytingco
IPC: C12Q1/6841 , C12Q1/6837
CPC classification number: C12Q1/6841 , C12Q1/6837
Abstract: Provided are methods of capturing an analyte from a biological sample using a hydrogel that includes capture probes to capture the analyte, identifying a region of interest of the biological sample, and isolating the region of interest from the biological sample by removing a portion of the hydrogel that corresponds to the region of interest. Compositions and kits for performing the methods are also provided.
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公开(公告)号：US12059645B1
公开(公告)日：2024-08-13
申请号：US17314627
申请日：2021-05-07
Applicant: 10X Genomics, Inc.
Inventor： Bill Kengli Lin , Eric Anderson , Pratomo Alimsijah , Alexander Post Kindwall , Kevin Gilmartin , Michael John Tierney
CPC classification number: B01D5/009 , B01D5/0009 , B01D5/0045 , B01D53/265 , B01J2219/0099
Abstract: Devices and methods are provided for reducing or removing condensation from compressed air.
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Patent Agency Ranking
公开(公告)号：US11833515B2
公开(公告)日：2023-12-05
申请号：US16859060
申请日：2020-04-27
Applicant: 10x Genomics, Inc.
Inventor： Tobias Daniel Wheeler , Bill Kengli Lin , Mohammad Rahimi Lenji , Anthony Makarewicz , Rajiv Bharadwaj
IPC: B01L3/00 , C12Q1/6869
CPC classification number: B01L3/502784 , B01L3/502761 , C12Q1/6869 , B01L2200/06 , B01L2200/16 , B01L2300/021 , B01L2300/0861
Abstract: Provided are microfluidics systems, devices, and networks for generating partitions. The microfluidics systems, devices, and networks may facilitate efficient merging of one or more channels in a microfluidic network and prevent blockage of a channel segment, such as by gas (e.g., air) bubbles or by one or more particles in a fluid.
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公开(公告)号：US20200165603A1
公开(公告)日：2020-05-28
申请号：US16419461
申请日：2019-05-22
Applicant: 10X Genomics, Inc.
Inventor： Kamila Belhocine , Rajiv Bharadwaj , Christopher Hindson , Michael Schnall-Levin , Bill Kengli Lin , Anthony Makarewicz , Pranav Patel , Katherine Pfeiffer , Andrew D. Price , Mohammad Rahimi Lenji , Tobias Daniel Wheeler , Yifeng Yin
IPC: C12N15/10 , C12Q1/6869 , C12Q1/6806
Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
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公开(公告)号：US20200024596A1
公开(公告)日：2020-01-23
申请号：US16419428
申请日：2019-05-22
Applicant: 10X Genomics, Inc.
Inventor： Kamila Belhocine , Rajiv Bharadwaj , Christopher Hindson , Michael Schnall-Levin , Bill Kengli Lin , Anthony Makarewicz , Pranav Patel , Katherine Pfeiffer , Andrew D. Price , Mohammad Rahimi Lenji , Tobias Daniel Wheeler , Yifeng Yin
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6869
Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
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公开(公告)号：US20240253036A1
公开(公告)日：2024-08-01
申请号：US18585357
申请日：2024-02-23
Applicant: 10x Genomics, Inc.
Inventor： Hanyoup Kim , Augusto Manuel Tentori , Siyuan Xing , Rajiv Bharadwaj , Bill Kengli Lin , Felice Alessio Bava , Pratomo Putra Alimsijah , Nabil Mikhaiel
IPC: B01L3/00 , C12Q1/6837 , C12Q1/6841 , G01N1/31
CPC classification number: B01L3/502715 , B01L3/502723 , C12Q1/6837 , C12Q1/6841 , G01N1/312 , B01L2200/027 , B01L2300/0822 , B01L2400/0421
Abstract: Provided herein is a fluid delivery method for permeabilizing a biological sample. The method includes delivering the fluid to a first substrate and/or a second substrate. At least one of the first substrate and the second substrate includes a spacer. The method further includes assembling, subsequent to the delivering, a chamber comprising the first substrate, the second substrate, the biological sample, and the spacer. The spacer may be disposed between the first substrate and second substrate. The spacer may be configured to maintain the fluid within the chamber and maintain a separation distance between the first substrate and the second substrate. The spacer may be positioned to at least partially surround an area on the first substrate on which the biological sample is disposed and/or at least partially surround the array disposed on the second substrate.
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公开(公告)号：US11565263B2
公开(公告)日：2023-01-31
申请号：US16840619
申请日：2020-04-06
Applicant: 10X Genomics, Inc.
Inventor： Rajiv Bharadwaj , Anthony Makarewicz , Bill Kengli Lin
IPC: B01L3/00 , G01N1/00 , G01N33/543 , B01F23/41 , B01F25/314 , B01F31/80 , B01F33/3011 , B01F33/302 , B01L3/02 , C12Q1/6806 , G01N33/58 , C12Q1/686 , C40B40/06
Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.
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