公开(公告)号：US06473633B1

公开(公告)日：2002-10-29

申请号：US09363477

申请日：1999-07-29

申请人： Ronald W. Heil, Jr. ,  Gregory R. Ley ,  Dwight Skinner ,  Larry L. Hum

发明人： Ronald W. Heil, Jr. ,  Gregory R. Ley ,  Dwight Skinner ,  Larry L. Hum

IPC分类号： A61B5042

CPC分类号： A61N1/0573

摘要： A helical element for insertion into tissue comprises a helical element having an insertion end, a protruding end and an open central area within the wire, rods, filaments, cables or the like that form the helix. The helical element has at least its insertion end covered by a cap of a water-soluble or water-dispersible composition. The cap is provided with a surface shape in a cross-section in which surface variations are present in the cross-section which create a surface orientation where a line from the center of the cross-section can intersect the surface, and a line perpendicular to said radius at a point of intersection with said surface forms four quadrants, three of said quadrants containing water-soluble or water-dispersible cap material. There is either a hollow area within the composition within the open central area or the material is more porous than the remaining material. The helical element preferably comprises an electrical lead, such as a positive endocardial lead, with an electrode at the protruding or distal end of the lead. The helical element may comprise any biocompatable material with sufficient structural integrity to provide a secure attachment to tissue in a patient. Where the helical element is also to provide an active (electrically active) function, the composition of the helical element should also be electrically conductive.

摘要翻译： 用于插入组织的螺旋元件包括螺旋元件，其具有插入端，突出端和形成螺旋的线内的开口中心区域，杆，细丝，电缆等。 螺旋元件的至少其插入端被水溶性或水分散性组合物的盖子覆盖。 盖在横截面中设置有表面形状，其中在横截面中存在表面变化，其产生表面取向，其中横截面中心的线可以与表面相交，并且垂直于 在与所述表面的交点处的所述半径形成四个象限，所述象限中的三个包含水溶性或水分散性盖材料。 组合物中的中空区域在开放的中心区域内，或者材料比剩余的材料多孔。 螺旋元件优选地包括电引线，例如正性心内膜引线，在引线的突出或远端具有电极。螺旋元件可以包括具有足够结构完整性的任何可生物相容的材料，以提供与 患者。 当螺旋元件也提供活性（电活性）功能时，螺旋元件的组成也应当是导电的。

公开(公告)号：US06584363B2

公开(公告)日：2003-06-24

申请号：US09906571

申请日：2001-07-16

申请人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

发明人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

IPC分类号： A61N105

CPC分类号： A61N1/0568 ,  A61N1/056

摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.

公开(公告)号：US5935160A

公开(公告)日：1999-08-10

申请号：US787274

申请日：1997-01-24

申请人： Angelo Auricchio ,  Rodney W. Salo ,  Bruce A. Tockman ,  Ronald W. Heil, Jr. ,  Randy Westlund ,  Stuart R. Chastain

发明人： Angelo Auricchio ,  Rodney W. Salo ,  Bruce A. Tockman ,  Ronald W. Heil, Jr. ,  Randy Westlund ,  Stuart R. Chastain

IPC分类号： A61N1/368 ,  A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip and transition ring that enhances the ability to guide the lead through the coronary veins.

摘要翻译： 具有减小的外径的细长单极或双极冠状静脉引线，并且特别适于前进到选定的冠状静脉以将起搏信号传送到患者心脏例如左心室的预定区域。 还描述了使用引线将患者心脏起搏治疗心力衰竭的方法。 用于起搏心脏的方法包括将冠状静脉导管穿过冠状窦并进入患者心脏的选定的冠状静脉，将导线连接到起搏源，并通过电刺激源将电刺激施加到患者心脏的特定腔室 植入铅。 引线包括一个灵活的尖端和过渡环，增强引导引导通过冠状静脉的能力。

公开(公告)号：US08060219B2

公开(公告)日：2011-11-15

申请号：US11017627

申请日：2004-12-20

申请人： Jeffrey Ross ,  John Kim ,  Rodney W. Salo ,  Ronald W. Heil, Jr. ,  Randy Westlund

发明人： Jeffrey Ross ,  John Kim ,  Rodney W. Salo ,  Ronald W. Heil, Jr. ,  Randy Westlund

IPC分类号： A61N1/05

CPC分类号： A61N1/0587 ,  A61N1/0568 ,  A61N1/059

摘要： An epicardial patch includes an extracellular matrix (ECM) and a plurality of electrodes. The isolated ECM is configured for epicardial attachment over a myocardial region including an injured area to control post-injury remodeling of the myocardial region. The plurality of electrodes is configured for delivering electrical stimulation to enhance the effect of the isolated ECM in remodeling control by altering workload and stress on the myocardial region.

摘要翻译： 心外膜贴片包括细胞外基质（ECM）和多个电极。 分离的ECM被配置用于在包括受伤区域的心肌区域上的心外膜附着以控制心肌区域的损伤后重建。 多个电极被配置为通过改变心肌区域上的工作负荷和压力来传递电刺激以增强孤立的ECM在重塑控制中的作用。

公开(公告)号：US07218971B2

公开(公告)日：2007-05-15

申请号：US10608850

申请日：2003-06-24

申请人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

发明人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

IPC分类号： A61N1/05

CPC分类号： A61N1/0568 ,  A61N1/056

摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.

摘要翻译： 心脏节律管理系统提供心内心律管理引线，至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。 溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。 一种这样的涂层的溶解释放治疗剂，例如修饰组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间产生的结合较弱，从而如果需要，铅可以容易地提取。 一个这样的引线包括至少承载的绝缘细长体。 引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。 在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

公开(公告)号：US06304786B1

公开(公告)日：2001-10-16

申请号：US09280096

申请日：1999-03-29

申请人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

发明人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

IPC分类号： A61N105

CPC分类号： A61N1/0568 ,  A61N1/056

摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.

摘要翻译： 心脏节律管理系统提供心内心律管理引线，其至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。 溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。 一种这样的涂层的溶解释放治疗剂，例如改变组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间的所得粘合力较弱，从而如果需要，铅可以容易地提取。 一个这样的引线包括至少承载的绝缘细长体。 引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。 在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

公开(公告)号：US20130144174A1

公开(公告)日：2013-06-06

申请号：US13674639

申请日：2012-11-12

申请人： John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

发明人： John D. Hatlestad ,  Binh C Tran ,  Bin Mi ,  Ronald W. Heil, Jr.

IPC分类号： A61B5/0205 ,  A61B5/03 ,  A61B5/20

CPC分类号： A61B5/0205 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/036 ,  A61B5/201 ,  A61B5/416 ,  A61B5/6846

摘要： An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device or in an external device/system.

摘要翻译： 用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器，用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期感测和产生 以周期性间隔代表患者的腹内压力值的输出。 提供至少一个第二可植入传感器用于感测和产生代表患者的第二生理参数的输出。 另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。 处理器可以驻留在另一个可植入设备中或外部设备/系统中。

公开(公告)号：US07392090B2

公开(公告)日：2008-06-24

申请号：US10672315

申请日：2003-09-26

申请人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

发明人： Robert J. Sweeney ,  Avram Scheiner ,  Ronald W. Heil, Jr.

IPC分类号： A61N1/00

CPC分类号： A61B5/0031 ,  A61N1/30 ,  A61N1/3621

摘要： A data logging system and method in which an implantable medical device transmits logged data to an external data logging device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded data by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external data logging device. The data logging device then demodulates the sensed potentials to derive the digital data and stores the data in a data logging storage medium.

摘要翻译： 一种数据记录系统和方法，其中可植入医疗设备将记录的数据发送到具有低能量电位信号的外部数据记录装置。 可植入装置通过操作电流源产生用数字编码数据调制的电位信号，以引起可由外部数据记录装置在皮肤表面感测到的对应电位。 数据记录装置然后解调所感测的电位以导出数字数据并将数据存储在数据记录存储介质中。

公开(公告)号：US07201733B2

公开(公告)日：2007-04-10

申请号：US09999260

申请日：2001-11-30

申请人： Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

发明人： Avram Scheiner ,  Mark Herner ,  Ronald W. Heil, Jr. ,  Steven D. Girouard

IPC分类号： A61M31/00

CPC分类号： A61N1/30 ,  A61N1/3621 ,  Y10S128/12 ,  Y10S128/13

摘要： A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

摘要翻译： 一种药物递送系统，其结合到心脏装置中，用于在检测到特定医疗状况时将药物的剂量递送给患者。 心脏装置可以是例如通过射频链路与药物递送装置进行通信的可植入式心律转复器/除颤器，心脏起搏器或组合装置。 药物递送装置优选是经电调制的透皮药物递送装置，用于根据从心脏装置接收的信号透皮地递送药物。

公开(公告)号：US5133365A

公开(公告)日：1992-07-28

申请号：US779526

申请日：1991-10-18

申请人： Ronald W. Heil, Jr. ,  Robert C. Owens

发明人： Ronald W. Heil, Jr. ,  Robert C. Owens

IPC分类号： A61N1/05 ,  A61N1/39

CPC分类号： A61N1/3956 ,  A61N1/056

摘要： An improved electrocardial lead for use with an automatic implantable cardioverter/defibrillator (AICD) comprises an elongated, flexible, plastic tubular catheter body which is preformed so that when unconstrained, it assumes the shape of a tapered spiral or helix. The catheter body supports a defibrillating electrode attached to the exterior wall of the catheter body and is connected by a suitable cable to a proximal connector for mating with the AICD pulse generator. The improved lead also includes a tip electrode for sensing cardiac activity and providing information to the AICD pulse generator for controlling its operation. The lead of the present invention is intended for endocardial emplacement with the electrode structures predominantly in the right ventrical and provides substantially increased electrode surface area in contact with heart tissue as compared to prior art endocardial defibrillating leads and, thus, maximizing the energy delivered to the heart during defibrillation.

摘要翻译： 用于与自动植入式心律转复除颤器（AICD）一起使用的改进的心电引线包括细长的，柔性的塑料管状导管体，其被预成型，使得当不受限制时，其呈现锥形螺旋或螺旋形的形状。 导管主体支撑附着在导管主体的外壁上的除颤电极，并通过合适的电缆连接到用于与AICD脉冲发生器配合的近端连接器。 改进的引线还包括用于感测心脏活动的尖端电极，并向AICD脉冲发生器提供信息以控制其操作。 本发明的领域旨在用于心电图放置，其中电极结构主要在右侧通气孔中，并且与现有技术的心内膜除纤维引线相比，提供与心脏组织接触的基本上增加的电极表面积，从而最大限度地提供给 除颤期间心脏。