公开(公告)号：US20060246138A1

公开(公告)日：2006-11-02

申请号：US11374228

申请日：2006-03-13

申请人： Catherine Rohloff ,  Stephen Berry ,  Ling-Ling Kang ,  Aruna Nathan

发明人： Catherine Rohloff ,  Stephen Berry ,  Ling-Ling Kang ,  Aruna Nathan

IPC分类号： A61K38/21 ,  A61K31/519 ,  A61K38/19 ,  A61K38/22 ,  A61K38/18 ,  A61K48/00 ,  A61K9/22 ,  A61K9/14

CPC分类号： A61K9/0024 ,  A61K9/0004

摘要： Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can be created.

摘要翻译： 液态聚氧乙烯聚合物材料被提供为适合于从递送装置例如泵驱动剂型分配药物活性剂如蛋白质的悬浮载体。 多氧酯由至少一种二酸和至少一种二醇制成。 通过使用聚氧乙烯醚，可以制成无溶剂的药物悬浮液。

公开(公告)号：US08114430B2

公开(公告)日：2012-02-14

申请号：US13100016

申请日：2011-05-03

申请人： Catherine Manya Rohloff ,  Stephen Andrew Berry ,  Ling-Ling Kang ,  Aruna Nathan

发明人： Catherine Manya Rohloff ,  Stephen Andrew Berry ,  Ling-Ling Kang ,  Aruna Nathan

IPC分类号： A61F13/00

CPC分类号： A61K9/0024 ,  A61K9/0004

摘要： Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can be created.

摘要翻译： 液态聚氧乙烯聚合物材料被提供为适合于从递送装置例如泵驱动剂型分配药物活性剂如蛋白质的悬浮载体。 多氧酯由至少一种二酸和至少一种二醇制成。 通过使用聚氧乙烯醚，可以制成无溶剂的药物悬浮液。

公开(公告)号：US20110264076A1

公开(公告)日：2011-10-27

申请号：US13100016

申请日：2011-05-03

申请人： Catherine Manya Rohloff ,  Stephen Andrew Berry ,  Ling-Ling Kang ,  Aruna Nathan

发明人： Catherine Manya Rohloff ,  Stephen Andrew Berry ,  Ling-Ling Kang ,  Aruna Nathan

IPC分类号： A61M37/00

CPC分类号： A61K9/0024 ,  A61K9/0004

摘要： Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can be created.

摘要翻译： 液态聚氧乙烯聚合物材料被提供为适合于从递送装置例如泵驱动剂型分配药物活性剂如蛋白质的悬浮载体。 多氧酯由至少一种二酸和至少一种二醇制成。 通过使用聚氧乙烯醚，可以制成无溶剂的药物悬浮液。

公开(公告)号：US07368125B2

公开(公告)日：2008-05-06

申请号：US10162933

申请日：2002-06-05

申请人： Aruna Nathan

发明人： Aruna Nathan

IPC分类号： A61F2/00 ,  A61K9/14

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/34 ,  C08L71/02

摘要： The present invention is directed to medical devices or pharmaceutical compositions, each containing a synthetic, bioabsorbable, biocompatible polymer that is the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a polyether.

摘要翻译： 本发明涉及医疗器械或药物组合物，其各自含有合成的，生物可吸收的生物相容性聚合物，其是多元酸或其衍生物，单酸甘油酯和聚醚的反应产物。

公开(公告)号：US20060210747A1

公开(公告)日：2006-09-21

申请号：US11340882

申请日：2006-05-05

申请人： Aruna Nathan ,  Joel Rosenblatt ,  Steven Arnold

发明人： Aruna Nathan ,  Joel Rosenblatt ,  Steven Arnold

IPC分类号： B32B27/08

CPC分类号： A61K9/7007 ,  A61K9/1647 ,  A61K9/204 ,  A61L17/005 ,  A61L17/145 ,  A61L27/18 ,  A61L27/46 ,  A61L27/58 ,  A61L31/06 ,  A61L31/148 ,  A61L2300/602 ,  Y10T428/1352 ,  C08L67/08

摘要： The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

公开(公告)号：US07030127B2

公开(公告)日：2006-04-18

申请号：US09896004

申请日：2001-06-29

申请人： Aruna Nathan ,  Joel Rosenblatt ,  Steven C. Arnold

发明人： Aruna Nathan ,  Joel Rosenblatt ,  Steven C. Arnold

IPC分类号： A61K31/505

CPC分类号： A61K9/7007 ,  A61K9/1647 ,  A61K9/204 ,  A61L17/005 ,  A61L17/145 ,  A61L27/18 ,  A61L27/46 ,  A61L27/58 ,  A61L31/06 ,  A61L31/148 ,  A61L2300/602 ,  Y10T428/1352 ,  C08L67/08

摘要： The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

公开(公告)号：US07026374B2

公开(公告)日：2006-04-11

申请号：US10178970

申请日：2002-06-25

申请人： Aruna Nathan ,  Joel Rosenblatt ,  Steven C. Arnold

发明人： Aruna Nathan ,  Joel Rosenblatt ,  Steven C. Arnold

IPC分类号： C08L15/00 ,  A61F2/00

CPC分类号： A61K47/34

摘要： The present invention is directed to microdispersions and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry, and a synthetic, bioabsorbable, biocompatible polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

公开(公告)号：US20050085605A1

公开(公告)日：2005-04-21

申请号：US10962274

申请日：2004-10-11

申请人： Aruna Nathan

发明人： Aruna Nathan

IPC分类号： C08G63/16 ,  A61L17/14 ,  A61L31/10 ,  C08G63/52 ,  C08G63/91 ,  C08F24/00

CPC分类号： A61L31/10 ,  A61L17/145 ,  C08G63/52 ,  C08G63/918

摘要： The present invention is directed to synthetic, biodegradable, biocompatible polymers that are the reaction product of an α,β-unsaturated polybasic acid or derivative thereof and a monoglyceride, and which further contain pended thereto a functional agent, and to medical devices and compositions containing such polymers.

公开(公告)号：US20050079202A1

公开(公告)日：2005-04-14

申请号：US10857609

申请日：2004-05-28

申请人： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Aruna Nathan ,  Joel Rosenblatt

发明人： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Aruna Nathan ,  Joel Rosenblatt

IPC分类号： A61F2/00 ,  A61K9/00

CPC分类号： A61K9/0024

摘要： Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric polymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

摘要翻译： 描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放 时间。 组合物包括生物相容的弹性体聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性体粘性凝胶并限制植入物吸收水分，以及有益剂。

公开(公告)号：US06866860B2

公开(公告)日：2005-03-15

申请号：US10323367

申请日：2002-12-19

申请人： Aruna Nathan

发明人： Aruna Nathan

IPC分类号： C08G63/685 ,  A61L27/18 ,  A61L27/58 ,  A61F2/00 ,  A61K31/70 ,  B32B7/02

CPC分类号： A61L27/58 ,  A61L27/18 ,  Y10S514/802 ,  Y10S514/816 ,  Y10T428/249921 ,  Y10T428/249953 ,  Y10T428/249958 ,  Y10T428/2982 ,  Y10T428/31786

摘要： The present invention is directed to medical devices or pharmaceutical composition, each containing a synthetic, biodegradable, biocompatible polymer that is the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.

摘要翻译： 本发明涉及医疗器械或药物组合物，其各自含有合成的，可生物降解的生物相容性聚合物，其是多元酸或其衍生物，单酸甘油酯和阳离子多元醇的反应产物。