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21 条记录 (耗时 0.021 秒)

    Methods and compositions relating to a vaccine against prostate cancer
    13.
    发明授权
    Methods and compositions relating to a vaccine against prostate cancer 有权
    与针对前列腺癌的疫苗相关的方法和组合物

    公开(公告)号：US08293701B2

    公开(公告)日：2012-10-23

    申请号：US11922633

    申请日：2006-06-21

    申请人： Christoph Leder ,  Alan D. King ,  Maxim Pavlenko ,  Pavel Pisa

    发明人： Christoph Leder ,  Alan D. King ,  Maxim Pavlenko ,  Pavel Pisa

    IPC分类号： A01N37/18

    CPC分类号： A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53

    摘要： An object of the invention is to provide methods and compositions relating to a vaccine against prostate cancer which includes a non-human-primate PSA for administration to humans to provide an immune response against human PSA. More generally, an object of the invention is to provide methods and compositions relating to using a non-human primate xenogeneic antigen (e.g. protein) in a human, wherein, with respect to the non-human primate xenogeneic antigen that is used, there are relatively few interspecies differences between the non-human primate xenogeneic antigen and the human self antigen in order to induce an optimal immune response in the human to its native self antigen.

    摘要翻译： 本发明的一个目的是提供与针对前列腺癌的疫苗相关的方法和组合物，其包括用于向人类施用以提供针对人PSA的免疫应答的非人灵长类PSA。 更一般地，本发明的目的是提供与人类中使用非人灵长类异种抗原（例如蛋白质）相关的方法和组合物，其中，关于所使用的非人灵长类异种抗原，存在 非人类灵长类异种抗原与人类自身抗原之间相对较少的种间差异，以便诱导人类对其天然自身抗原的最佳免疫应答。

    Method and apparatus for the delivery of polynucleotide vaccines to mammalian skin
    15.
    发明授权
    Method and apparatus for the delivery of polynucleotide vaccines to mammalian skin 有权
    用于将哺乳动物皮肤递送多核苷酸疫苗的方法和装置

    公开(公告)号：US08979818B2

    公开(公告)日：2015-03-17

    申请号：US13065135

    申请日：2011-03-15

    申请人： Derin C. Walters ,  Alan D. King ,  Anna-Karin Roos ,  Robert J. Walters

    发明人： Richard E. Walters ,  Derin C. Walters ,  Alan D. King ,  Anna-Karin Roos

    IPC分类号： A61N1/30 ,  A61M31/00 ,  A61M35/00 ,  A61N1/32 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

    CPC分类号： A61N1/327 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/70 ,  A61N1/306 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134

    摘要： An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and to reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method for the delivery of polynucleotide vaccines into mammalian skin cells includes the steps of: (a.) administering a polynucleotide vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity to the administration site, and (c.) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the polynucleotide vaccine into the skin cells by electroporation. The sequence of at least three waveforms has one, two, or three of the following characteristics (1) at least two of the at least three waveforms differ from each other in waveform amplitude, (2) at least two of the at least three waveforms differ from each other in waveform width, and (3) a first waveform interval for a first set of two of the at least three waveforms is different from a second waveform interval for a second set of two of the at least three waveforms.

    摘要翻译： 本发明的目的是提供一种用于将多核苷酸疫苗递送到哺乳动物皮肤细胞中以增加T细胞应答并减少由于长电波形应用引起的疼痛和不适以及由于肌肉收缩引起的疼痛和不适的方法和装置。 用于将多核苷酸疫苗递送到哺乳动物皮肤细胞中的方法包括以下步骤：（a）在给药部位将多核苷酸疫苗施用于皮肤，（b）将针电极施用于给药的附近的皮肤 站点，以及（c）应用脉冲间隔小于100毫秒的至少三个单个，操作者控制的，独立编程的窄间隔电波形序列，以通过电穿孔将多核苷酸疫苗递送到皮肤细胞中 。 至少三个波形的序列具有以下特征（1）中的一个，两个或三个，所述至少三个波形中的至少两个波形在波形幅度上彼此不同，（2）至少三个波形中的至少两个波形 在波形宽度上彼此不同，以及（3）至少三个波形中的两个的第一组的第一波形间隔与用于至少三个波形中的两个的第二组的第二波形间隔不同。

    SAFETY CATHETER DEVICE WITH REMOVABLY ATTACHED HOUSING
    16.
    发明申请
    SAFETY CATHETER DEVICE WITH REMOVABLY ATTACHED HOUSING 有权
    安全导管装置，具有可拆卸的外壳

    公开(公告)号：US20120259293A1

    公开(公告)日：2012-10-11

    申请号：US13527248

    申请日：2012-06-19

    申请人： Dennis M. Bialecki ,  David J. Goral ,  Alan D. King

    发明人： Dennis M. Bialecki ,  David J. Goral ,  Alan D. King

    IPC分类号： A61M5/00

    CPC分类号： A61M5/3273 ,  A61M25/0606 ,  A61M25/0618 ,  A61M2005/325

    摘要： A safety catheter device includes a catheter hub, a housing removably coupled to the catheter hub; a needle, and a member, the housing including a radially outwardly directed projection operable to engage the interior aspect of the catheter hub and radially moveable inwardly sufficiently to disengage therefrom, the projection being held against moving radially inwardly sufficiently to disengage when the needle is in a first position with the needle distal tip exposed and being free to move radially inwardly sufficiently to disengage coincident with the needle being moved into a second position with the needle distal tip disposed in the housing.

    摘要翻译： 安全导管装置包括导管座，可移除地联接到导管座的壳体; 针和构件，所述壳体包括径向向外指向的突出部，其可操作以接合导管毂的内部方面并且可向内径向向内移动，以足以与其分离，所述突出部被保持抵抗径向向内径向向内移动，以在针处于 第一位置，其针远端尖端暴露并且可自由地向内径向向内移动以使针脱离，使针移动到第二位置，其中针远端设置在壳体中。

    Safety catheter device with removably attached housing
    18.
    发明授权
    Safety catheter device with removably attached housing 有权
    安全导管装置，具有可移除连接的外壳

    公开(公告)号：US08647301B2

    公开(公告)日：2014-02-11

    申请号：US13527248

    申请日：2012-06-19

    申请人： Dennis M. Bialecki ,  David J. Goral ,  Alan D. King

    发明人： Dennis M. Bialecki ,  David J. Goral ,  Alan D. King

    IPC分类号： A61M5/00 ,  A61M5/178

    CPC分类号： A61M5/3273 ,  A61M25/0606 ,  A61M25/0618 ,  A61M2005/325

    摘要： A safety catheter device includes a catheter hub, a housing removably coupled to the catheter hub; a needle, and a member, the housing including a radially outwardly directed projection operable to engage the interior aspect of the catheter hub and radially moveable inwardly sufficiently to disengage therefrom, the projection being held against moving radially inwardly sufficiently to disengage when the needle is in a first position with the needle distal tip exposed and being free to move radially inwardly sufficiently to disengage coincident with the needle being moved into a second position with the needle distal tip disposed in the housing.

    摘要翻译： 安全导管装置包括导管座，可移除地联接到导管座的壳体; 针和构件，所述壳体包括径向向外指向的突出部，其可操作以接合导管毂的内部方面并且可向内径向向内移动，以足以与其分离，所述突出部被保持抵抗径向向内径向向内移动，以在针处于 第一位置，其针远端尖端暴露并且可自由地向内径向向内移动以使针脱离，使针移动到第二位置，其中针远端设置在壳体中。

    Methods and Compositions Relating To a Vaccine Against Prostate Cancer
    20.
    发明申请
    Methods and Compositions Relating To a Vaccine Against Prostate Cancer 有权
    关于疫苗对前列腺癌的方法和组合

    公开(公告)号：US20100047260A1

    公开(公告)日：2010-02-25

    申请号：US11922633

    申请日：2006-06-21

    申请人： Christopher Leder ,  Alan D. King ,  Maxim Pavlenko ,  Pavel Pisa

    发明人： Christopher Leder ,  Alan D. King ,  Maxim Pavlenko ,  Pavel Pisa

    IPC分类号： A61K39/00 ,  A61K31/711 ,  A61P37/04 ,  A61P35/00

    CPC分类号： A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53

    摘要： An object of the invention is to provide methods and compositions relating to a vaccine against prostate cancer which includes a non-human-primate PSA for administration to humans to provide an immune response against human PSA. More generally, an object of the invention is to provide methods and compositions relating to using a non-human primate xenogeneic antigen (e.g. protein) in a human, wherein, with respect to the non-human primate xenogeneic antigen that is used, there are relatively few interspecies differences between the non-human primate xenogeneic antigen and the human self antigen in order to induce an optimal immune response in the human to its native self antigen.

    摘要翻译： 本发明的一个目的是提供与针对前列腺癌的疫苗相关的方法和组合物，其包括用于向人类施用以提供针对人PSA的免疫应答的非人灵长类PSA。 更一般地，本发明的目的是提供与人类中使用非人灵长类异种抗原（例如蛋白质）相关的方法和组合物，其中，关于所使用的非人灵长类异种抗原，存在 非人类灵长类异种抗原与人类自身抗原之间相对较少的种间差异，以便诱导人类对其天然自身抗原的最佳免疫应答。